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Química Farmacéutica I. Tema 6. Fármacos analgésicos, antipiréticos y antiinflamatorios no esteroideos (AINEs)
No full textTemas de la Asignatura Química Farmacéutica I de 3º de Farmacia
Juegos y materiales alternativos para la actividad física adaptada. Una propuesta educativa
No full textLa Actividad Física (AF) es esencial para la salud y bienestar de todas las personas. Dentro de esta disciplina,
la Actividad Física Adaptada es, actualmente, una de las áreas de conocimiento en pleno desarrollo en el
ámbito de las Ciencias de la Actividad Física y del Deporte. De la mano de la Pedagogía, constituyen un gran
dúo para promover la AF en las personas con discapacidad y afrontar su baja tasa de práctica deportiva
Design of helical winding for slotless partially superconducting electric machines for aircraft propulsion
No full textThis paper presents a promising winding technique which enables higher power-densities in partially superconducting electrical machines with a slotless stator, e.g., self-supporting windings. Firstly, the formulation for defining the skewing factor of the helical winding is given. Afterwards, the skew angle and how diverse winding configurations can be characterised as a function of this angle is explained, along with different parameters such as the skewing factor, the harmonic content of the magnetomotive force wave in the airgap or the resistance per phase of the winding. The sine-shaped winding, a particular case of helical winding, is shown, with which, thanks to the benefits of the additive manufacturing, a better electromagnetic performance is achieved. Finally, the implementation of the helical winding configuration in a slotless partially superconducting 2MW high-power and high-voltage electric machine for electric aircraft propulsion is assessed, comparing the machine active part weight and their power density
La clase como equipo de proyecto
No full textLa asignatura de Proyectos en Química (4o curso
del grado en Química) da una visión general al alumno del concepto de
proyecto, relacionándolo especialmente con aquellos a los que se puede
enfrentar en su futuro profesional.
La asignatura, con 3ECTS, tiene una carga fundamentalmente teórica,
aunque con muchos ejemplos de aplicaciones prácticas ofrecidas por el
profesor. Se imparte semanalmente en una franja horaria de 2 horas de
clase seguidas. En este proyecto se propone involucrar a la clase en la
elaboración de un proyecto que pudiera ser real. Para ello se dividirán los
alumnos en grupos de trabajo bajo un objetivo de proyecto común
(elegidos por ellos mismos). En este sentido, habrá un grupo centrado en
el estudio de mercado y mercadotecnia, otro en el diseño del producto o
servicio, otro en estudio financiero, etc. La profesora responsable figurará
como el director de proyecto. Con la implantación de este proyecto se
espera una mejor asimilación de los conceptos teóricos, así como poner en
práctica algunas herramientas útiles a la hora de llevar a cabo la idea de un
proyecto
Bienestar de la juventud española: como están y qué necesitan de la sociedad
No full textAnalizar los determinantes del bienestar psicosocial ha sido cada vez más frecuente en los estudios de las últimas décadas. A través de un diseño explicativo secuencial, en el que en primer lugar se analizan datos cuantitativos y posteriormente cualitativos se abordan dos objetivos. Primero, explorar las diferencias de género, edad y el nivel socioeconómico en el florecimiento y la satisfacción con la vida en la juventud española. Segundo, detectar qué necesidades identifican las personas jóvenes como promotoras de su bienestar. La muestra estuvo compuesta por 3.003 jóvenes residentes en España (48.7 % mujeres) de edades comprendidas entre 16 y 29 años (16-18: 21.4 %; 19-24: 42.1 % y 25- 29: 36.6 %) participantes en el estudio Wellbeing during Adolescence and Emerging Adulthood (WAEA). Los resultados indicaron que la juventud presenta un nivel alto de florecimiento y un nivel medio de satisfacción con la vida. Se encontraron diferencias significativas en florecimiento y satisfacción con la vida en función del género, la edad y el nivel económico. Las personas jóvenes destacaron principalmente tres necesidades básicas para lograr su bienestar: la salud mental, los recursos económicos y las relaciones sociales satisfactorias. Además, la juventud española indicó que la sociedad puede contribuir a su bienestar fomentando valores sociales más igualitarios y justos y generando mejoras económicas. Sin embargo, cabe destacar que parte de la muestra señaló que no hay nada que la sociedad pueda hacer para mejorar su nivel de bienestar psicosocial. En conclusión, se reconoce a la adolescencia y la adultez emergente como etapas positivas en cuanto al bienestar psicosocial y se destaca la necesidad de acompañar y fortalecer los factores de protección individuales, así como crear condiciones económicas y sociales igualitarias que permitan a las personas jóvenes alcanzar un desarrollo óptimo e integral confiando en la sociedad para ello
Design and testing of steel additive-manufactured moment-resistant beam-to-column connection
Full text linkThe objective of this research is to study an alternative to conventional moment-resisting beam-to-column steel joints through the design of optimised connections made by additive manufacturing using steel. The proposed design is intended to fulfil design criteria such as the following: the connection has to be moment-resistant, and the different structural elements should join as easily as possible, enabling them to be attached and detached and consequently allowing the reuse of steel. The design is achieved by the application of Structural Topological Optimisation tools from the software TOSCA, and it is verified by finite element analysis using ABAQUS. The proposed design reshapes the material and leads to a uniform and optimised distribution of stresses. Blind bolts are no longer necessary and a significant weight reduction is achieved.
The final design was printed with S316 stainless steel using the Selective Laser Melting technique, and it was tested under proportional loads until failure. The finite element models were validated with the experimental results. Then, the behaviour of the proposed connection under proportional and non-proportional loads is compared with that of a connection executed by traditional means (welded and bolted plates), as well as a conventional fully welded connection. The proposed connection exhibits a better behaviour than the other connections in terms of stiffness and resistance. In fact, when compared with the conventional welded connection, the values of the stiffness and strength of the optimised design are much higher. In addition, the significantly larger values of the stiffness/weight and strength/weight ratios highlight the efficiency of the proposed design
Evolutionary Explanations of Pain and Suffering: A ‘Gift to Theology’ or a Challenge
Full text linkEvolutionary studies have provided several explanations about how pain and suffering can be fitted into that framework, which tries to make sense of every biological and human feature in terms of evolution, survival, and fitness. These explanations point usually to how such apparently negative aspects become useful and contribute to an evolution that after all has delivered good outcomes. Such an approach might eventually render the theodicy question less sharp and critical for believers who are trying to cope with the scandal of so great suffering in our world and history. Theologically we can welcome such new insights, less noticed in former tradition, but at the same time we need to be cautious before a development which could render less clear the message of Christian salvation. In any case, the new data and knowledge clearly invite to revise and reformulate the Christian salvific message, to better answer before the mystery of evil and suffering
Combating repeated lies: The impact of fact‐checking on persistent falsehoods by politicians
No full textThe rise of repeated false claims within political discourse is undermining fact‐checking efforts.
By reiterating similar statements that perpetuate previous falsehoods, political actors shift from
misinformation to deliberate disinformation and even propagandistic tactics. Through an analysis of
1,204 political fact‐checks conducted by the Spanish fact‐checking organization Newtral, this study
quantifies and characterizes the prevalence of repeated false claims in political discourse, revealing that a
substantial 24.8% of false statements are repeated, with each being repeated an average of four times.
By delving into the nature and types of claims most susceptible to recurrence, the study identifies five
primary patterns employed by political actors: nuanced variations, data manipulation, multilateral attacks,
discourse qualification, and cumulative repetition. These tactics blur the lines between deception and
self‐correction. The annotated database of these repeated false statements can serve as a valuable resource
for exploratory qualitative analysis as well as claim‐matching research in automated fact‐checking
The ELECLA trial: A multicentre randomised control trial on outcomes of neoadjuvant treatment on locally advanced colon cancer
No full textBackground: Colon cancer (CC) is a public health concern with increasing incidence in younger populations. Treatment for locally advanced CC (LACC) involves oncological surgery and adjuvant chemotherapy (AC) to reduce recurrence and improve overall survival (OS). Neoadjuvant chemotherapy (NAC) is a novel approach for the treatment of LACC, and research is underway to explore its potential benefit in terms of survival. This trial will assess the efficacy of NAC in LACC.
Methods: This is a multicentre randomised, parallel-group, open label controlled clinical trial. Participants will be selected based on homogenous inclusion criteria and randomly assigned to two treatment groups: NAC, surgery, and AC or surgery followed by AC. The primary aim of this study is to evaluate the 2-year progression-free survival (PFS), with secondary outcomes including 5-year PFS, 2- and 5-year OS, toxicity, radiological and pathological response, morbidity, and mortality.
Discussion: The results of this study will determine whether NAC induces a clinical and histological tumour response in patients with CCLA and if this treatment sequence improves survival without increasing morbidity and mortality
