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    Advancing MRI diagnostic practices in rectal cancer:exploring the impact of web-based multi-reader study participation

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    PURPOSE: To explore the impact of participation in web-based validation studies on personal and institutional diagnostic practices for MRI rectal cancer (re)staging. METHODS: An online questionnaire was distributed to radiologists who had participated in one or more previously conducted and published multi-reader validation studies focused on rectal cancer staging and response evaluation. The questionnaire included general questions about the web-based platform used for these studies, as well as study-specific questions addressing the tools under investigation, such as diffusion-weighted imaging (DWI), different MRI response grading systems, and the sigmoid take-off (STO). RESULTS: Among 25 respondents from 14 countries, 52% reported significant improvements in their personal reporting practice as a result of their study participation; 36% also observed a significant impact on local diagnostic practices in their institution after discussing the study results with their colleagues. Key reported effects included increased use of DWI for restaging, increased use of the STO to discern rectal from sigmoid cancer, enhanced confidence in using diagnostic tools and grading systems, greater adoption of structured reporting templates, and more frequent integration of organ-preserving treatment considerations into radiological assessments. Respondents also emphasized the importance of receiving feedback to maximize the educational benefits of participating in such studies. CONCLUSION: Web-based validation studies can positively influence radiologists' reporting practices, fostering the adoption of novel diagnostic tools through education and collaborative knowledge sharing. Future studies should focus on incorporating consistent feedback mechanisms and integrating specific training modules to maximize the impact of these platforms on clinical practice

    Freud as Linguistic Innovator and Founder of Discourse

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    Sigmund Freud’s influence on language extends far beyond psychoanalysis, shaping both everyday speech and intellectual discourse. By favoring accessible vocabulary over technical medical language, he ensured that key psychoanalytic concepts—such as the unconscious, projection, and the Oedipus complex—gained widespread familiarity among the general public. Even his critics, often unconsciously, ‘speak Freud’, thereby reinforcing his enduring intellectual legacy. Yet, James Strachey’s English translation of Freud’s work introduced Greek and Latin neologisms that, while lending Freud’s original terms a more scientific veneer, also made them more abstract and detached, contributing to the emergence of a rigid psychoanalytic jargon—what has become known as ‘psychoanalese’. This linguistic shift not only complicated the reception of psychoanalysis but also encouraged misunderstandings about its scope. Nevertheless, Freud’s sophisticated oeuvre, in which scientific rigor is blended with literary expression, continues to resonate. He remains a profound influence, not only as the father of psychoanalysis but also—perhaps even more so—as a masterful writer whose ideas shape language and thought

    Replication Data for: "Taxing the Wealthy in Haiti: Evidence from a survey experiment on property tax preferences"

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    Replication Data for: "Taxing the Wealthy in Haiti: Evidence from a survey experiment on property tax preferences" (2025-01-17

    Seeing is believing:are investors' corporate online visits as informative as site visits?

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    This paper examines the post-visit earnings forecast inaccuracy of online visits (visits via videoconferencing) relative to site visits (visits to production or operation sites) with data from China between 2020 and 2021. We use the number of confirmed COVID-19 infections in the city where analysts' offices are located as an instrument for the choices between online visits and site visits. Our results show that online visits fail to maintain the accuracy of analysts' EPS forecasts. Moreover, the diminished financial reporting quality of firms amplifies the forecasting disadvantages associated with online visits. Finally, the lack of site observation rather than one-on-one communication is the primary reason for the underperformance of online visits

    Stable support, scant initiative:European business associations and Economic and Monetary Union, 1946-1992

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    The article investigates the views of European business associations on the Economic and Monetary Union (EMU) project between 1946 and 1992. In doing so, it places the campaign for EMU organised by the Association for the Monetary Union of Europe in the run-up to the Maastricht Treaty into its previously neglected historical context. The article argues that although European business associations supported EMU in general, their views concerning its construction evolved and differed. As a result of these divergences, they only responded to political proposals made by others, instead of pro-actively pushing a specific agenda forward

    “I could have married in Europe, if I wanted to” How black migrant men challenge moralizing and racializing discourses when returning to Senegal

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    Marriage offers one of the few routes for Senegalese migrants to enter Europe and settle there legally, and it is often assumed that migrants marry just for a residence permit. “Marriage migration” is highly scrutinized by state actors, whose admission practices and their consequences have been the focus of much research. Less, however, is known about the perspectives of migrants who left Europe in response to these practices. Drawing on one year of ethnographic fieldwork, we show how male Senegalese returnees and deportees challenge the idea that men want to marry a European resident at all costs. These men are spatially excluded from Europe but they discursively regain their dignity by returning to Senegal. Their return also challenges gendered and racialized European narratives about dangerous and hypersexual black Muslim males, and at the same time reinforces their positioning in moral hierarchies about love and marriage

    The Revival of Sorbents in Chronic Dialysis Treatment

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    Interest in the use of sorbents in chronic dialysis treatment has undergone a revival in the last decades, for which two major factors are responsible. The first is the potential of sorbents as adjunct therapy for the removal of substances that are difficult to remove by conventional dialysis therapies. The second is their use in regeneration of dialysate, which is of pivotal importance in the design of portable or even wearable treatments, next to the potential for reducing water use during conventional dialysis treatment. Sorbent-enhanced dialysis with synthetic polymers was associated with a reduction in inflammatory parameters as compared to hemodialysis and even associated with improved survival in smaller studies, although this needs to be confirmed in large randomized trials. Incorporation of sorbents within a dialysis membrane (mixed matrix membrane) appears a promising way forward to reduce the complexity and costs of a dual therapy but needs to be tested in vivo. For regeneration of dialysate, at present, a combination of urease, zirconium-based sorbents, and activated charcoal is used. Next to sodium release by the sorbent in exchange for ammonium and the CO2 release by the hydrolysis of urea has been a bottleneck in the design of wearable devices, although short-term trials have been performed. Still, for widespread and flexible application of sorbent-assisted portable or wearable devices, a direct urea sorbent would be a major asset. In the near future, it will likely become apparent whether sorbent-assisted dialysis techniques are feasible for routine implementation in clinical practice

    Was Robert Gibrat right? A test based on the graphical model methodology

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    Using both regression analysis and an unsupervised graphical model approach (never applied before to this issue), we confirm the rejection of Gibrat’s Law (stating that a firm’s growth is independent of that firm’s initial size) when our firm-level data are considered over the entire investigated period, while the opposite is true when we allow for market selection; indeed, the growth behavior of the surviving most efficient firms is in line with Gibrat’s Law. This evidence reconciles early and current literature and may have interesting implications in terms of both theoretical research and policy suggestions regarding subsidies to small firms, which do not necessarily grow faster than their larger counterparts.</p

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