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Corrigendum to “A geometry-based model for non-invasive estimation of pressure gradients over iliac artery stenosis” [J. Biomech. 92 (2019) 67–75]
No full textThe authors regret finding a discrepancy1 between Equation (7) and its visual representation in Figure 3B of the original manuscript. In Equation (7), the definition of the Kt-value is found to be incorrect. A retrospective analysis has resulted in the following correction: a. CORRECTION DEFINITION OF Kt-VALUEThe correct equation should be:[Formula presented] This was purely a typographical error and did not affect the results whatsoever, as the computational analysis was performed with the correct equation above. The authors would like to apologise for any inconvenience caused
Cohort Study of Indecent Exposure in the Netherlands from 2012 to 2020:Incidents, Perpetrators, Victims, and Trends over Time
Get PDFIndecent exposure is often regarded as a nuisance offense and detailed studies into this topic are relatively rare. However, there is consensus that relatively high recidivism rates and risk of escalation to more severe offenses can be of serious concern among these perpetrators. This cohort study aims to increase our general knowledge on the basic characteristics of these offenses and includes all registered police cases of indecent exposure in the Netherlands between 2012 and 2020, including 6741 incidents, involving 4663 suspects and 3808 registered victims. This first study of a large cohort over a long period of time describes the basic characteristics of these incidents, the perpetrators and their victims, and visualizes the results to explore trends over time. Results show that a modal indecent exposure incident is perpetrated by a 25-year-old male, on foot, on a public road, on a Wednesday afternoon in July, masturbating and directing his genitals intentionally toward a 13-year-old girl. The age distribution of victims shows remarkable similarity to victims of sexual assault. Compared to the first year of the period studied, the number of annually reported incidents gradually declined to half in the last year of the study. Findings are discussed in light of the most prominent theories on exhibitionism. Issues and suggestions relevant to apprehension and treatment of perpetrators are identified and discussed
Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease
No full textINTRODUCTION: Alterations in locus coeruleus’ (LC) metabolic turnover are associated with Alzheimer's disease (AD)-pathology and cognitive impairment. However, the evolution of these changes across disease stages and their functional relevance remains unknown. METHODS: We examined associations of [ 18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) -derived LC metabolism with clinical diagnostic status, cerebrospinal fluid (CSF) -based AD biomarkers of AD pathology, and cognitive decline in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n = 604). RESULTS: FDG-PET-derived LC metabolism was elevated in the earliest preclinical stages and lower in later disease stages. Higher LC metabolism was associated with attenuated memory decline in preclinical stages, particularly in those with low CSF Aβ 42, but not in AD patients with cognitive impairment. DISCUSSION: Higher locus coeruleus [ 18F]-FDG-PET-derived signal in the early preclinical stages of AD can confer cognitive resilience and may reflect increased metabolic activity, whereas later stages are characterized by lower LC FDG-PET-derived signal, possibly due to neurodegeneration. Highlights: LC FDG-PET signal is lower in Alzheimer's disease (AD) patients. LC FDG-PET signal is higher in the preclinical stage of AD. We observed less memory decline in those with higher LC FDG-PET signal. Higher LC FDG-PET signal conferred cognitive resilience in preclinical AD.</p
Tactile tastes:Testing the relation between tactile thresholds, liking of textures and pickiness in eating
No full textThe texture of foods plays an important role in the liking of foods. Especially for picky eaters, texture can be a reason to reject foods. Previous studies showed that picky eaters in general dislike tactile stimulation more, which can include the feel of sand in their hands and specific food textures in their mouth. It has been suggested that this dislike stems from lower thresholds to detect touch, causing textures to feel over-stimulating and therefore more aversive. Alternatively, picky eaters might have the same objective tactile thresholds, but different subjective evaluations. The aim of the present study is to test the relations between tactile thresholds, liking of textures, food liking and picky eating. In a sample of 86 adult participants, picky eating was measured with the Adult Picky Eating Questionnaire (APEQ) and food liking with the Food Liking Questionnaire (FLQ). Tactile thresholds were tested with Semmes-Weinstein monofilaments (both on the tongue and fingertip) and liking of different textures was measured by feeling several textures with the hands. Results showed that both tongue and fingertip tactile thresholds were not related to the liking of textures. Thresholds of the fingertip, but not the tongue, were weakly related to food liking, but not directly to the APEQ. Liking of textures was related to both food liking and the APEQ. The results indicate that picky eaters indeed have a general subjective dislike of textures, but this cannot be explained by lower tactile thresholds. Future research might focus on how differential liking of textures develops
Identification performance across the life span:Lineups and the reaction time-based Concealed Information Test
No full textCognitive and social factors can deteriorate eyewitness identification performance in children and older adults. An identification procedure that mitigates the effect of such factors could be beneficial for child and older adult witnesses. In a field experiment, we mapped identification performance in a large community sample (N = 1239) across the lifespan (ages 6-79 years) for two different identification procedures: classic lineups and reaction time-based Concealed Information Test (RT-CIT). Visitors of a science museum or science fair witnessed a recorded mock theft and then took either a classic lineup, or the RT-CIT. Young adults (18-35-year-olds) outperformed younger and older age groups in lineup performance. The RT-CIT showed a moderate capacity to diagnose face recognition and absence of recognition in the target-absent condition. Age did not affect identification with the RT-CIT. However, children were often not able to follow the RT-CIT instructions, leading to a large number of exclusions. A direct comparison of lineup vs. RT-CIT performance showed that children and adolescents showed better identification performance in RT-CIT than lineups. For young adults, there was no difference between the two procedures. The trend turned around at mid-adult age who showed better identification performance when they were given a lineup compared to an RT-CIT. These findings suggest that the RTCIT might be considered an alternative identification procedure for children and adolescents, offering protection for innocent suspects
Explanatory variables of objectively measured physical activity, sedentary behaviour and sleep in adults with type 1 diabetes:A systematic review
Get PDFAimsThis systematic review aimed to summarize knowledge on explanatory variables of PA, SB and sleep in adults with T1D to support the development of healthy lifestyle interventions.MethodsA systematic search of four databases (PubMed, Web of Science, Scopus and Embase) was performed. Only objective measurements of PA, SB and sleep were included and all explanatory variables were classified according to the socio-ecological model (i.e. intrapersonal, interpersonal, environmental and policy level). Risk of bias (ROB) (Joanna Briggs Institute appraisal checklists) and level of evidence (Evidence-Based Guideline Development) were assessed.ResultsTwenty-one studies were included (66.7% low ROB). Most explanatory variables were situated at the intrapersonal level. A favourable body composition was associated with more time spent in total PA and moderate-to-vigorous PA (MVPA). Men with T1D spent more time in MVPA than women and a younger age was associated with increased MVPA. Barriers to PA were indeterminately associated with MVPA and HbA1c showed an indeterminate association with sleep. Explanatory variables of SB and light PA were not studied in at least two independent studies.ConclusionThis review underscores the focus on the individual level to identify explanatory variables of movement behaviours in adults with T1D, despite the necessity for a socio-ecological approach to develop effective interventions. More evidence on psychological, interpersonal and environmental variables is needed as these are modifiable
Frailty and body composition predict adverse outcomes after emergency general surgery admission:a multicentre observational cohort study
No full textIntroduction Emergency surgical admissions represent the most unwell patients admitted to any hospital. Frailty and body composition independently identify risk of adverse outcomes but are seldom combined to predict outcomes in emergency patients. We aim to determine the relationships between frailty, body composition analyses (BCA) and mortality in an undifferentiated emergency general surgical patient population. Method A prospective, multicentre observational cohort study of patients admitted with emergency surgical pathology was conducted in eight hospitals. BCA were performed at L3 vertebrae using computed tomography images to quantify sarcopenia and myosteatosis. Sex-specific BCA cut-off values were determined by our previous study. Reported Edmonton Frail Scale (REFS) values ≥8 identified frailty. The primary outcomes were all-cause 30-day and 1-year mortality. Multivariable logistic regression was utilised to explore predictive relationships between frailty, BCA, mortality and independent discharge. Results A total of 194 patients were included; 24% were frail, 25% were sarcopenic and 23% myosteatotic. Some 61% of patients underwent an emergency laparotomy. Frail patients were more likely to be sarcopenic (20.4% vs 40.4%; p = 0.011) and myosteatotic (27.2% vs 51.1%; p = 0.004). Thirty-day and 1-year mortality was 5.2% and 15.5%, respectively; 30-day mortality was two times higher in the frail group (4.1% vs 8.5%; p = 0.414), and three times higher at 1 year (10.2% vs 31.9%; p = 0.001). Age (odds ratio [OR] 1.06; p = 0.001), sarcopenia (OR 2.88; p = 0.047) and frailty (OR 4.13; p = 0.001) were associated with 1-year mortality. Only 55.3% of frail patients were discharged home independently compared with 88.4% non-frail patients (p < 0.001). One-year mortality was greater in those with frailty and/or BCA abnormalities than in those without (28.8% vs 9.6%; p = 0.003). Conclusion Frailty, sarcopenia and myosteatosis contribute significantly to adverse outcomes.</p
Improving sleep quality in nurses who work irregular shifts:necessity and first steps towards intervention
Get PDFThe impact of prebiotics, probiotics, and gut-derived metabolites on intestinal health and skeletal muscle metabolic and oxidative capacity
Get PDFTMS in the Kingdom of Denmark:an overview of current clinical practice
No full textPurpose: Repetitive TMS (rTMS) has been demonstrated to be an effective treatment of several neuropsychiatric disorders. Its safety and efficacy are well established, and multiple rTMS devices have been approved by both Conformitè Europëenne Mark and U.S. Food and Drug Administration. We aimed to survey TMS practice in Psychiatry in the Kingdom of Denmark and compare it with the international state of the art. Methods: A survey of rTMS clinical practice in 2023 was sent to all general adult psychiatry departments practicing TMS in the Danish Realm (Denmark = 10, Faroe Islands = 0, Greenland = 0). Results: Response rate was 100%. rTMS was available in 37% of psychiatric departments and 3 out of 5 Danish Regions. Admission criteria required a diagnosis of unipolar depression with a degree of treatment-resistance or unacceptable side-effects to antidepressant treatment. Common contraindications included: cochlear implants (100%), pacemaker and neurostimulators (80%), other ferromagnetic/implanted devices in head, neck, or thorax (70%), active substance misuse (60%), and electrolytic disturbances (50%). Three rTMS protocols were identified: 10 Hz rTMS delivered over the L-DLPFC, iTBS delivered over the L-DLPFC and 1 Hz rTMS delivered over the right-DLPFC. 383 patients were treated with TMS. Conclusions: rTMS is unequally available in the public healthcare of the Kingdom of Denmark. Existing strategies for solving inequalities could address such issues. Unipolar depression was the only psychiatric disorder treated with rTMS in 2023. rTMS practice in the Danish Realm considers the use of evidence-based protocols and is consistent with recommendations from international expert guidelines.</p