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P45 Impaired autophagy signalling in cutaneous squamous cell carcinoma: a novel therapeutic target
No full textFamilial medullary thyroid carcinoma secondary to an <i>SLC30A9</i> intragenic deletion and translation reinitiation
No full textCylindrical extensions of critical Sobolev type inequalities and identities
No full textIn this paper, we investigate cylindrical extensions of critical Sobolev type (improved Hardy) inequalities and identities in the style of Badiale-Tarantello [6], which in a special case give a critical Hardy inequality and its stability results. We also obtain higher-order identities, which interestingly include well-known numbers like double factorial, Oblong numbers, and Stirling numbers of the second kind. All functional identities are obtained in Lp for p∈(1,∞) without the real-valued function assumption, which gives a simple and direct understanding of the corresponding inequalities as well as the nonexistence of nontrivial extremizers. As applications, we obtain Caffarelli-Kohn-Nirenberg type inequalities with logarithmic weights, which in a particular case give the critical case of the Heisenberg-Pauli-Weyl type uncertainty principle. We also discuss these results in the setting of Folland and Stein's homogeneous Lie groups. A special focus is devoted to stratified Lie groups, where Sobolev type inequalities become intricately intertwined with the properties of sub-Laplacians and more general subelliptic partial differential equations. The obtained results are already new even in the classical Euclidean setting with respect to the range of parameters and the arbitrariness of the choice of any homogeneous quasi-norm. Most inequalities are obtained with sharp constants
Best Practice in Preoperative Surgical Planning for Robotic-assisted Radical Prostatectomy: A European Consensus Statement.
No full textBACKGROUND AND OBJECTIVE: The surgical plan in robotic-assisted radical prostatectomy (RARP) aims to achieve optimal perioperative, oncological, and functional outcomes by recommending the extent of resection and use of function sparing techniques. However, there is a lack in high-level evidence on the optimal process to define the plan preoperatively. We therefore undertook a consensus exercise to develop the best practice statement to supplement evidence-based guidelines. METHODS: A consensus exercise was undertaken using a modified RAND/University of California Los Angeles approach. Consensus was a priori defined as ≥75% agreement/disagreement. A total of 101 statements were developed by the steering group based on a previously published systematic review and were reviewed in three rounds by 14 panellists. KEY FINDINGS AND LIMITATIONS: Overall, 73 statements reached consensus and 34 reached consensus across six domains. The process concluded that a preoperative surgical plan is essential prior to undertaking any RARP and will facilitate the optimal execution of surgery, as it provides the best available information to the surgeon to refine the technique and potentially improve oncological, functional, and perioperative outcomes. CONCLUSIONS AND CLINICAL IMPLICATIONS: The consensus statements draw out the best practices in the surgical planning process and can assist surgeons in standardising their approach. Gaps (areas of nonconsensus) have also been identified that can direct future work
The dark side of brands: Exploring fear of missing out, obsessive brand passion, and compulsive buying
Get PDFChoice of Isolation method has a significant impact on average murine Telomere Length estimates
No full textReduced Thermal Conductivity and Improved Stability by B-Site Doping in Tin Halide Perovskites
Get PDFHalide perovskites have attracted recent attention as thermoelectric materials due to their low thermal conductivity combined with good charge transport characteristics. The tin halide perovskites hold the highest zT within metal halide perovskites and offer lower toxicity than lead-containing perovskites that are well-known for photovoltaics. In this study, we partially substitute Sn (II) with Ge (II) to form mixed metal CsSn1–xGexI3 perovskite thin films that have substantially improved stability, remaining in the black orthorhombic phase after hours of ambient air exposure. We find Ge (II) at the surface seems to be oxidized in preference to Sn (II), and this retards oxidation of the bulk of the film. Moreover, Ge substitutions dramatically reduce the lattice thermal conductivity to 0.26 ± 0.01 Wm–1K–1 for CsSn0.9Ge0.1I3 at 353 K. Density functional theory simulations show that Ge-doped Sn perovskites possess more low-frequency phonon modes than pristine CsSnI3, which leads to stronger scattering among the acoustic phonons, resulting in lower phonon group velocity and reduced phonon lifetime. These findings make an important contribution to our understanding of the origin of the reduced lattice thermal conductivity and improved electrical stability of B-site doped perovskite materials
The African Critical Illness Outcomes Study (ACIOS): A point prevalence study of critical illness in 22 nations in Africa
Get PDFBackground
Critical illness represents a major global health-care burden and critical care is an essential component of hospital care. There are few data describing the prevalence, treatment, and outcomes of critically ill patients in African hospitals.
Methods
This was an international, prospective, point prevalence study in acute hospitals across Africa. Investigators examined all inpatients aged 18 years or older, regardless of location, to assess the coprimary outcomes of critical illness and 7-day mortality. Patients were classified as critically ill if at least one vital sign was severely deranged. Data were collected for the available resources at each hospital and care provided to patients.
Findings
We included 19 872 patients from 180 hospitals in 22 African countries or territories between September, 2023 and December, 2023. The median age was 40 (IQR 29–59) years, and 11 078/19 862 (55·8%) patients were women. There were 967/19 780 (4·9%) deaths. On census day, 2461/19 743 (12·5%) patients were critically ill, with 1688/2459 (68·6%) cared for in general wards. Among the critically ill, 507/2450 (20·7%) patients died in hospital. Mortality for non-critically ill patients was 458/17 205 (2·7%). Critical illness on census day was independently associated with subsequent in-hospital mortality (adjusted odds ratio 7·72 [6·65–8·95]). Of the critically ill patients with respiratory failure, 557/1151 (48·4%) were receiving oxygen; of the patients with circulatory failure, 521/965 (54·0%) were receiving intravenous fluids or vasopressors; and of patients with low conscious level, 387/784 (49·4%) were receiving an airway intervention or placed in the recovery position.
Interpretation
One in eight patients in hospitals in Africa are critically ill, of whom one in five dies within 7 days. Most critically ill patients are cared for in general wards, and most do not receive the essential emergency and critical care treatments they require. Our findings suggest a high burden of critical illness in Africa and that improving the care of critically ill patients would have the potential to save many lives