Swiss School of Archaeology in Greece
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Traitements ultra-personnalisés, Le dilemme des coûts, compte-rendu d'entretien édité par Olivier Dessibourg, avec également Jacques Cornuz et Pascal Strupler, soutenu par la Fondation Leenards
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Follicular Helper T-Cell Lymphomas With Epstein-Barr Virus-Positive Neoplastic Cells: A Rare Scenario With Diagnostic Implications
No full textFollicular helper T-cell lymphomas (TFHLs) of the angioimmunoblastic type (AITL) and other TFHL variants often contain Epstein-Barr virus (EBV)-positive B blasts, but EBV infection of the neoplastic T cells has rarely been documented. Here, we report 10 cases of TFHL (9 AITLs and 1 TFHL not otherwise specified) associated with EBV infection in neoplastic T cells. The patients (5 men and 5 women), aged 56 to 81 years, presented with polyadenopathy (8/8), B symptoms (7/7), and skin lesions (4/7). EBV was confirmed in neoplastic follicular helper T-cell (TFH) by double labeling for EBV, T-cell markers (CD5 or CD3), and PD1/ICOS. In 2 patients, EBV infection in TFH was demonstrated in biopsies at relapse of an AITL (n = 2). In 3 cases, the abundance of EBV in large atypical B cells had led to a mistaken diagnosis of either classic Hodgkin lymphoma or EBV-positive large B-cell lymphoma, with the diagnosis subsequently confirmed as AITL in 2 of the 3 patients. A high viral load was observed in the 3 tested patients. Lymph node biopsies showed the typical pathological, phenotypic, and genetic features of TFHL with a CD4+ (10/10), CD10+ (5/10), PD1+ (10/10), ICOS+ (8/8), CXCL13+ (8/8), BCL6+ (5/9) TFH phenotype of the neoplastic cells, follicular dendritic cell expansion (9/10), and mutations in TET2 (10/10), RHOA (p.G17V variant in 8 cases and a previously unreported RHOA p.D120N variant in 1 case), DNMT3A (5/10), and CD28 (2/9) genes. Using PCR, type-1 EBV was detected in all 9 patients tested. All 7 patients with follow-up data available showed rapid disease progression and died 2-8 months after the diagnosis. This study shows that EBV type 1 can infect TFH cells in TFHL. Further studies are needed to understand whether the crosstalk between TFH cells and EBV-infected B cells plays a role in this phenomenon and to determine the potential clinical relevance of EBV in TFHL.
Copyright © 2025 United States & Canadian Academy of Pathology. All rights reserved
Types of Myocardial Infarction in People With HIV in Switzerland
No full textOf myocardial infarctions (MIs) recorded in 2 large human immunodeficiency virus (HIV) observational studies from North America, approximately half were classified as type 2. In the REPRIEVE clinical trial of pitavastatin versus placebo in people with HIV (PWH) (<3% of participants were from Europe), 20.6% of MIs were type 2. The proportions of type 1 MI (T1MI) and type 2 MI (T2MI) in European PWH are unknown.
The study included a retrospective record review, ascertainment of prospectively recorded and medically validated MIs, differentiation of T1MI and T2MI, and MI time trend analysis in the Swiss HIV Cohort Study (1 January 2000 to 31 May 2021). Exploratory analysis was performed of the associations of T1MI and T2MI with blood leukocyte count and 2 validated genome-wide coronary artery disease-associated polygenic risk scores (metaGRS and GPSmult).
Between 2000 and 2021, 16 027 Swiss HIV Cohort Study participants accumulated 181 598 years of follow-up, and 379 had a validated first MI. Of these participants, 359 (94.7%) had T1MI, and 20 (5.3%) had T2MI. Invasive coronary angiography was done in 95% and 60% of participants with T1MI and T2MI, respectively. We found no evidence for increasing or decreasing incidence trends over time for T1MI (P = .86) or T2MI (P = .85). Participants in the highest quintile for leukocyte count, metaGRS, and GPSmult had significantly increased adjusted odds ratios for T1MI; power was limited for detecting associations with T2MI.
The proportion of T2MI in PWH in Switzerland is approximately 5%, consistent with data from the general population and lower than in previous North American reports among PWH.
© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America
A Mixed Methods Study of (Dis)satisfaction with Open Government Data Portals: A User-Centric Perspective
No full textIn recent years, governments have emerged as the biggest data holders, producing extensive amounts of historical and contemporary data. The demand for transparency has led to the rise of Open Government Data (OGD): data produced or collected by state bodies made freely accessible, modifiable, shareable, and usable by anyone for any purpose with minimal restrictions. OGD is seen as a foundation for economic growth, competitiveness, innovation, job creation, and societal progress. For example, the total direct economic benefits of OGD in the EU and UK are forecast to increase from €52 billion in 2018 to €194 billion in 2030. To maximise these benefits, governments have adopted supply-driven strategies focused on producing large volumes of datasets, assuming greater supply will lead to greater use. OGD portals have been developed as central access points, but they often fail to meet users’ needs. In Switzerland, for instance, most respondents report that the national OGD portal does not meet their needs. This reflects a misalignment between supply and demand: large volumes of data lead to data pollution, while limited data literacy makes it harder for users to find and use relevant data. This thesis argues that OGD portals reveal cross-cutting issues across the OGD ecosystem — production, distribution, and use — that reinforce this misalignment. It examines the usability of the Swiss OGD portal and shows that poor usability can make data practically inaccessible, especially for users with limited technical skills who rely on the portal as their only access point. Improving usability is key to ensuring OGD strategies succeed in bridging the gap between supply and demand
Proprioception impacts body perception in healthy aging - Insights from a psychophysical and computational approach
No full textThe way we perceive our body and its dimensions depends on how our brain combines multisensory information. As the human sensory system declines with age, we hypothesize that body perception may change during aging. We investigated this hypothesis by comparing body ownership (BO) and upper limb perceived dimensions (mBR) in young and older individuals (>65 years). We used computational and psychophysical methods to quantify alterations in mBR and BO, and modeled their relationship with sensorimotor and cognitive factors. Results revealed altered body perception in healthy older adults, with significant underestimation in arm dimensions and increased feeling of ownership over an incongruent virtual hand, incorporating it into their motor plans. Reduced abilities in localizing one's own body in space (i.e., proprioception) emerged as a common factor influencing both BO and mBR. These findings pave the way for stimulation strategies to maintain or restore body perception in aging.
© 2025 The Author(s)
Outcome Prediction by Diffusion Tensor Imaging (DTI) in Patients with Traumatic Injuries of the Median Nerve
No full textBackground/Objectives: The accurate quantification of peripheral nerve axonal regenera-
tion after injury is critically important. Current strategies are limited to detecting early reinnervation.
DTI is an MRI modality permitting the assessment of fractional anisotropy, which increases with
axonal regeneration. The aim of this pilot study is to evaluate DTI as a potential predictive factor
of clinical outcome after median nerve section and microsurgical repair. Methods: We included
10 patients with a complete section of the median nerve, who underwent microsurgical repair up
to 7 days after injury. The follow-up period was 1 year, including the current strategy with clinical
visits, the Rosén–Lundborg score and electroneuromyography. Additionally, DTI MRI of the injured
wrist was planned 1, 3 and 12 months post-operatively and once for the contralateral wrist. Results:
The interobserver reliability of DTI measures was almost perfect (ICC 0.802). We report an early
statistically significant increase in the fractional anisotropy value after median nerve repair, especially
in the region located distal to the suture. Meanwhile, Rosén–Lundborg score gradually increased
between the third and sixth month, and continued to increase between the sixth and twelfth month.
Conclusions: DTI outcomes three months post-operation could offer greater predictability compared
to current strategies. This would enable faster decision-making regarding the need for a potential
re-operation in cases of inadequate early reinnervation
Mapping body-related research within the experimental landscape of anorexia nervosa: a scoping review
No full textAnorexia Nervosa (AN) is a complex psychiatric disorder characterized not only by restrictive eating behaviors and fear of weight gain, but also by emotional dysregulation, cognitive rigidity, and a profound disturbance in bodily experience. While bodily disturbance is clinically central, its multifaceted and pre-reflective nature has made it difficult to investigate experimentally. This scoping review aims to map the experimental case-control literature on AN from the past 15 years, with particular attention to how studies on body representation are represented within the broader field of AN research, both in terms of their prevalence and their subdivision into specific thematic domains.
A systematic search was conducted on PubMed, Scopus, and Web of Science. Studies were included if they involved an experimental task comparing individuals with AN to healthy controls.
The search yielded six hundred and three eligible studies, each classified into one or more thematic domains: cognition, emotion/social cognition, food-related processing, reward, and body representation. Among these, one hundred and sixty four studies addressed body representation and were further categorized into five subdomains: body image, perception of other bodies, body schema, sensory processing, and interoception.
While studies on cognition, emotion, reward, and food processing often used standardized paradigms and showed moderate methodological consistency, research on the bodily domain was notably heterogeneous. This reflects both the conceptual complexity of corporeality and the lack of unified frameworks for its empirical investigation. A recent shift toward multisensory and embodiment-based paradigms suggests increasing interest in implicit and integrative models of body representation. By identifying patterns, gaps, and emerging trends, this review underscores the need for greater conceptual clarity and interdisciplinary convergence. Advancing the experimental study of body representation in AN may support more comprehensive models of the disorder and enhance our understanding of bodily experience in psychiatric conditions.
Copyright © 2025 Gentili, Meregalli, Risso, Giovannini, Zambon, Bassolino, Serino, Favaro and Collantoni