Swiss School of Archaeology in Greece
UNIL IRIS | Institutional Research Information SystemNot a member yet
170689 research outputs found
Sort by
Confirmation of the Enhancement Effect of ANCE Treatment on Functional Recovery of Manual Dexterity From Primary Motor Cortex (M1) Lesion in Adult Macaque Monkeys
No full textA pilot study provided preliminary evidence indicating that peri-lesional adult autologous neural cell ecosystem transplantation (so-called ANCE) can enhance the functional recovery of manual dexterity in macaque monkeys following a unilateral lesion of the hand representation in the primary motor cortex (M1). As compared to five untreated control animals subjected to M1 lesions, the improvement of functional recovery was observed in our pilot study in two ANCE-treated monkeys (also M1 lesioned). To strengthen these promising preliminary results, the present study aimed at introducing two additional ANCE monkeys, as well as one new control monkey, all subjected to M1 lesion.
Manual dexterity was assessed based on the modified Brinkman board task, performed with the contralesional hand to retrieve small food pellets from slots using the precision grip (opposition of thumb and index finger).
As with the two pilot ANCE-treated monkeys, the two new ANCE-treated monkeys exhibited a rebound of functional recovery (a second plateau) associated to the treatment (after approximately 2-3 months delay post-treatment), following a first plateau of spontaneous recovery. In contrast, all control monkeys (n = 6) exhibited a single plateau of functional recovery.
The present study confirms that ANCE treatment significantly improves functional recovery from motor cortex lesions in adult macaques, with performance gains ranging from 20% to 40%. These findings support a possible future initiative to initiate clinical trials based on ANCE therapy.
© 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC
Not a lymph node: ultrasonographic identification of a double pyramidal lobe of the thyroid gland
No full textThe Quantification of Tourism Mobility and the Politics of Data: the case of Venice
No full textIn recent years, Venice has often been considered a symbol of overtourism, a place where tourism statistics are not merely cited but actively mobilised to denounce the negative impacts of tourism on urban liveability and to justify specific policy interventions. This dissertation critically examines the production and use of tourism mobility statistics in Venice, treating numbers not as neutral reflections of reality but as socially constructed and politically charged artefacts. It addresses the growing role of quantification in public discourse and urban governance, particularly in destinations grappling with what is framed as ‘too much tourism’. In such contexts, numerical representations of tourist flows increasingly serve to legitimise managerial decisions, influence policy, and shape public perceptions.
Drawing from the Social Studies of Quantification (SSQ), Critical Data Studies (CDS), Geography, and Tourism Studies, the research develops a conceptual and methodological framework to explore the socio-technical, institutional, and political dimensions of tourism data. The dissertation examines how statistics have been historically constructed, how they circulate across public and institutional domains, and how they are embedded in technological infrastructures such as the Smart Control Room
« L’acte de lire des romans d’amour : évasion et instruction », Traduction en français du chapitre 3 de Radway J., Reading the Romance. Women, Patriarchy, and Popular Literature, Chapell Hill, The University of North Carolina Press, 1984, p. 86-118
No full textSocial media listening study to understand the journey and unmet needs of patients living with post-stroke spasticity
No full textStroke survivors may develop spasticity (post-stroke spasticity [PSS]) that can challenge activity and participation. Recognising the needs and expectations of people with PSS is crucial for enhancing care. This study is the first to employ social media listening to explore the experiences, unmet needs, and quality of life (QoL) of people with PSS.
A subset of 417 patient-centric PSS-related posts published on major social media platforms was identified for analysis from 31 600 retrieved.
Posts mainly discussed patient journey (centred around treatment options and management techniques), the impact of PSS on QoL, and patient interactions with healthcare practitioners (HCPs). Widely used treatment options had associated negative sentiments due to perceived inefficacy and lack of long-term effectiveness (botulinum neurotoxin) or side effects (oral anti-spasticity medications). Perceptions of treatment options and expected treatment outcomes influenced satisfaction with treatment and HCP interactions. Poor perceived treatment efficacy generally resulted in dissatisfaction with HCP interactions and seeking peer opinions online. Identified unmet needs focused on need for satisfactory treatment options, well-informed HCPs, and better patient education.
The study highlights the need for improved education for patients, caregivers, and HCPs regarding PSS and better communication between patients and HCPs to manage treatment expectations
Letter to the Editor: Current role of the pericoronary fat attenuation index in breast cancer patients undergoing chemotherapy
No full text
Effectiveness of Stromal Vascular Fraction (SVF) and Platelet-Rich Plasma (PRP) in Patients With Knee Osteoarthritis: Protocol for a Phase 3, Prospective, Randomized, Controlled, Multicenter Study (SPOST Study)
No full textBackground: Available evidence on the conservative treatment of knee osteoarthritis still leaves questions about the efficacy of platelet-rich plasma (PRP) and whether stromal vascular fraction (SVF) offers a superior therapeutic tool.
Objective: This study aims to assess the clinical efficacy of SVF as adjuvant therapy to PRP on functionality and tissue regeneration for knee osteoarthritis.
Methods: In a multicenter, randomized, triple-blind, controlled trial, 108 individuals with knee osteoarthritis will be block-randomized in a 1:1 ratio. Patients will receive an initial single PRP or PRP + SVF injection followed by PRP doses at 1 month and 2 months. The primary endpoint is functional improvement measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at the 6-month follow-up. Secondary endpoints, collected at the 1-month, 2-month, 3-month, 6-month, and 12-month follow-ups, will include the pain visual analogue scale during maximal physical activity, WOMAC score, length of time to return to work and sports in days, magnetic resonance imaging (MRI)–based Whole-Organ Magnetic Resonance Imaging Score (WORMS), Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score, MRI Area Measurement and Depth and Underlying Structures (AMADEUS) score at 6 months and at 12 months, adverse events, and serious adverse events.
Results: Participant recruitment and data collection are expected to begin in July 2025 and finish in July 2027. Final end points will be gathered in August 2027, and the results are expected to be published in late 2027.
Conclusions: The study results will provide insight into the clinical efficacy of SVF as adjuvant therapy to PRP on functionality and tissue regeneration in patients with knee osteoarthritis
Feral edges: How permaculture is rewilding Japan's food culture on abandoned lands
No full textPermaculture lies at a double edge: it proposes a countercultural vision that is materialised at the hidden confines of Japan’s rural territory. From those cultural and territorial edges, it becomes possible to discreetly dissociate from the mainstream and experiment with novel visions and sustainability transformations at the individual- and farm-scale levels. It is not (yet) possible to quantify permaculture and, it is no less challenging to qualitatively unveil its importance, as it has instigated both drastic shifts and subtle changes, and because the people and places it inspires do not always publicly claim their affiliation to the permaculture movement. Still, permaculture has served some deep life reorientations and is quite dramatically re-designing some of Japan’s rural landscapes going feral in the context of depopulation and food commodification