Swiss School of Archaeology in Greece
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Neuroblastoma in Infants: Long-Term Survival From INES Protocols A SIOPEN Study
No full textNeuroblastoma is the most common extracranial solid tumor in infants, with a possibility of spontaneous regression even in disseminated disease. Despite an overall good prognosis, relapse can worsen the outcome for some patients. A long-term analysis is crucial to identify subgroups of patients with poorer prognosis, assessing the risks of late relapse, progression or long-term toxicity associated with multimodal treatment in very young children.
Estimation of the 10-year event-free and overall survivals in 750 infants under 12 months with neuroblastoma, enrolled in the prospective INES protocols between 1999 and 2004. Follow-up data from INES patients were updated, and survival analyses were performed in order to determine prognostic factors such as age, stage, genomic profile, or MYCN amplification.
Overall, 10-year overall survival was 91.1% ± 1.0%, and 10-year event-free survival was 82.4% ± 1.4%, with significantly better outcomes in infants under 6 months compared with those aged 6-12 months, even considering the MYCN-amplified tumors only. MYCN amplification was the strongest prognostic factor and was correlated with lower survival in patients with metastatic disease.
Survival in patients less than 12 months remains excellent and stable even at long term, as a 10-year follow-up did not change the number of events. However, survival in MYCN-amplified tumors remained poor. Patients with metastatic tumors require accurate risk stratification. For each treatment group, there was no significant difference in long-term outcomes compared with previous publications from INES. No lethal toxicity affecting long-term survival occurred.
© 2025 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC
Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition.
No full textPatients with critical illness may present with disease-related malnutrition upon intensive care unit (ICU) admission. They are at risk of development and progression of malnutrition over the disease trajectory because of inflammation, dysregulated metabolism, and challenges with feeding.
The Global Leadership Initiative on Malnutrition (GLIM) convened a panel of 36 clinical nutrition experts to develop consensus-based guidance statements addressing the diagnosis of malnutrition during critical illness, using a modified Delphi approach with a requirement of ≥75% agreement.
CONCLUSION: Research using consistent etiologic and phenotypic variables offers great potential to assess the efficacy of nutrition interventions for critically ill patients with malnutrition. Assessment of these variables at during and beyond the ICU stay will clarify the trajectory of malnutrition and enable exploration of impactful treatment modalities at each juncture. GLIM offers a diagnostic approach that can be used to identify malnutrition in critically ill patients
Work experiences of healthcare professionals in a shortage context: analysis of open-ended comments in a Swiss cohort (SCOHPICA).
No full textHealthcare systems worldwide face critical shortages of healthcare professionals (HCPs), threatening care quality and system sustainability. In Switzerland, limited training capacities further worsen the situation. While factors, such as job satisfaction, work-life balance, and burnout, are well-documented, most studies focus on specific professions, limiting their generalizability. This study provides an interprofessional analysis of HCPs' experiences regarding their working conditions in the context of workforce shortages, identifying key challenges that could inform retention strategies.
Open-ended comments from 1,811 participants in the HCPs part of the Swiss Cohort of Healthcare professionals and Informal caregivers (SCOHPICA-HCP), covering over 30 healthcare professions, were analyzed using computer-assisted textual analysis (IRaMuTeQ). Thematic classes were identified through hierarchical classification, and chi-square tests were conducted to examine associations with participant characteristics (e.g., profession, work setting, job satisfaction).
Three main themes emerged. First, participants highlighted gaps in training, including inadequate preparation for professional realities, limited career development opportunities, and challenges in diploma recognition. Second, systemic failures -such as staff shortages, inadequate wages, and administrative overload - were linked to stress, burnout, and declining care quality. Many participants perceived a disconnect between political decisions and frontline realities, further fueling dissatisfaction. Third, irregular working schedules, particularly night shifts, were seen as barriers to work-life balance and physical health, while also negatively impacting social and family responsibilities. Frustration over the lack of professional influence in shaping healthcare policies was a recurring concern.
This study identifies key challenges influencing HCP retention, emphasizing the importance of restoring trust through transparent communication and professional engagement in policy making. Rather than relying on overly generalized approaches, retention efforts should be tailored to clusters of professionals with shared working conditions. Additionally, this study highlights three key insights: the growing distrust in the healthcare system and in policy makers as significant aspect in HCPs' experience, shifting generational attitudes toward work commitment, and the need for collaborative programs between professional schools and employers to enhance work preparedness. These findings underscore the need for systemic changes to support workforce sustainability
Diagnosis of gestational diabetes after Roux-en-Y Gastric Bypass: A comparative analysis of three methods
No full textThe Kanarese Evangelical Mission in the Interwar Years (1918-1928): A Terrain for Social, Cultural and Religious Exchanges?
No full textIl parlato nella narrativa contemporanea. Su alcuni aspetti della trattazione del discorso riportato
No full textTailored Dementia Care across Seven Swiss Memory Clinics: The CareMENS Model Improves Patients' Mood and Quality of Life
No full textDementia is a growing global health concern, requiring a comprehensive approach to care. The CareMENS model is a non-pharmacological intervention designed to ensure continuity of care for individuals at the early stages of cognitive decline (CDR ≤1) or those with subjective cognitive complaints. It combines tailored neuropsychological, speech and language, and physical therapies with community-based leisure activities to sustain cognitive and physical function, promote social engagement and enhance overall patient well-being. A care manager - a new role introduced within Swiss memory clinics implementing the model - provides personalized and ongoing support.
This observational study was conducted across seven memory clinics in Western Switzerland between September 2020 and January 2024. It evaluated the acceptability and impact of the CareMENS model of care through the following outcomes: anxiety and depression symptoms (HADS), functional autonomy (DAD-6), global cognition (MoCA), and quality of life (WHOQOL). Pre-post analyses were performed in 184 patients (median age: 74 years old; 53.3% women) assessed at baseline (T0) and, on average, 324.2 days later (T1). Changes over time were evaluated using a linear mixed-effects model. A retrospective standard care group (N = 165) of patients aged ≥50 years (median age: 74 years old; 53.9% women) and with a dementia severity score (CDR) ≤1 was included for comparison of HADS, DAD-6, and MoCA outcomes.
The CareMENS model was successfully implemented into routine clinical practices of the participating memory clinics. Compared to standard care, the CareMENS intervention was associated with greater improvements in HADS-depression overall scores (-0.853, 95% CI = -1.441 to -0.265; p = 0.005) and in HADS-anxiety scores among patients with high baseline anxiety (-1.134, 95% CI = -2.134 to -0.133; p = 0.027). No significant between-groups differences were found in MoCA (0.361, 95% CI = -0.32 to 1.04; p = 0.299) and DAD-6 scores (0.892, 95% CI = -3.5 to 5.28; p = 0.69). Following the intervention, we observed positive within-group changes in the WHOQOL mean total score (+2.67, 95% CI = 1.31 to 4.02; p < 0.001) and particularly in the social participation subdomain (+6.1, 95% CI = 3.82 to 8.32; p < 0.001).
These findings indicate that the CareMENS model of care can be effectively implemented into clinical settings. It showed a significant reduction in mood symptoms and suggested positive benefits for quality of life. Integrating care management models into memory clinics may enhance patient outcomes and represents a promising direction for the evolution of current memory clinic practice.
© 2025 The Author(s). Published by S. Karger AG, Basel
Women and international assignments: A systematic literature review exploring textual data by correspondence analysis
No full textPurpose: Research on female expatriates has been substantially growing over the last decades and particularly in more recent years. Complementing previous thematic analyses of the literature, this paper applies textual statistics and correspondence analysis to reveal the existing semantic structure of the field of research on female expatriates.
Design/methodology/approach: Using correspondence analysis, we explore textual data from the abstracts of 151 identified journal articles published in English since 1975. We obtain a graphical representation showing the various developmental stages of research on female expatriates.
Findings: We find that research follows a home-host country orientation and advances from an organizational focus toward individual-level studies. We identify various directions for future research and especially a strong need for more multilevel approaches to study men's and women's expatriate experiences and trajectories in various contexts.
Research limitations/implications: Only articles with abstracts entered our analysis, which in turn was dependent on the content and quality of these abstracts. This limitation has been addressed by thoroughly reading each article considered.
Originality/value: This review adopts an original method in research on (female) expatriates and more broadly management research. It enabled us to map out the development of key research themes over time. Based on this analysis, gaps in current research could be identified and clear directions for future research were formulated
