Swiss School of Archaeology in Greece
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Author Correction: Computational design of synthetic receptors with programmable signalling activity for enhanced cancer T cell therapy
No full textAn updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière's disease
No full textIntegrating patient reported outcomes measures (PROMs) into hypertension management: a participatory design study leading to the HeartCare interprofessional digital platform
No full textIntroduction: Hypertension affects over 1 billion people worldwide, yet only 1 in 5 patients effectively manage their condition. Even in Switzerland, over 50% of adults with hypertension do not reach blood pressure targets. The International Consortium for Health Outcomes Measurement (ICHOM) developed a PROMs set to evaluate hypertension management. PROMs are validated self-report instruments capturing patients' perspectives on health and quality of life. Incorporating PROMs into chronic care management has the potential to enhance communication, patient engagement, and outcomes. This study explores stakeholders opinions on the ICHOM PROM set and develops a strategy to implement it in a digital interprofessional tool for Swiss primary care settings.
Method(s): From March to December 2024, patients with hypertension, pharmacists and GPs participated in three rounds of participatory design. The first session explored the ICHOM PROM set’s relevance for Swiss stakeholders. Subsequent sessions refined prototypes of a PROM-based interprofessional digital platform. Each round involved 4 to 7 end-user representatives. Discussions were transcribed, coded inductively, and analysed thematically to identify stakeholders needs and concerns.
Result(s): Healthcare providers (HCPs) recognize advantages of PROMs such as a better understanding of the patient's health status and enabling personalised care, but also disadvantages such as the length of the questionnaires and the potential unreliability of the answers. Integrating PROMs into existing health information systems was perceived as a solution. Patients appreciated the potential benefits of PROMs but expressed concerns about their usefulness. They emphasized the importance of presenting PROMs feedback in a clear, personalized manner relevant to their health journey. The participatory design pro cess shaped HeartCare’s features: on the mobile app, patients complete PROMs, receive real-time feedback, and track blood pressure values. Their data is accessible to their HCPs on a web platform, hopefully benefitting an individualized care.
Conclusion: This study successfully developed a solution for integrating PROMs into a digital platform for hypertension management. The participatory process ensured that the platform met both HCPs' and patients’ preferences. HeartCare’s features and development journey will be presented at the conference. A pilot study will evaluate its feasibility in real-world settings
Therapeutic vs. Recreational Use of Cocaine: Avoiding Diagnostic and Judicial Errors Through Interprofessional Collaboration-A Five-Case Report
No full textBackground/Objectives: Due to its potent local anesthetic and vasoconstrictive properties, cocaine is sometimes used in otolaryngologic surgical interventions. However, cocaine topical administration is not always adequately documented by practitioners, which can lead to serious legal consequences, particularly in the context of drug-impaired driving (DUID) investigations. This study retrospectively analyzes five road accident cases where cocaine was detected in biological samples after medical interventions. Case descriptions: Following pedestrian-car, or car-car accidents, five distinct patients aged between 30 and 84 years underwent maxillofacial surgery due to significant injuries. Given the severity of the accident and the circumstances, the police requested blood toxicological analysis to determine whether the patients were under the influence of psychoactive substances at the moment of the accidents. Results: The five cases described in this manuscript had blood cocaine concentrations exceeding the Swiss legal limit for drivers (15 µg/L). Since no information was initially provided about the medical use of cocaine after the crash, recreational use of cocaine was suspected. However, subsequent investigations confirmed that the cases involved medical administration. Conclusions: After sinonasal procedures involving the topical application of cocaine, patients may yield positive results on urine and blood drug tests, potentially resulting in serious legal repercussions, including the withdrawal of their driving license. Therefore, practitioners should thoroughly document the medical use of topical cocaine, particularly in DUID cases. These results also raise questions about the benefit-risk ratio of such use, considering that alternatives exist
Projet Mocca : résultats de l’évaluation du pilote. 3. L’expérience des professionnel∙les
No full textLes résultats de l’évaluation présentés ici concernent l’expérience des professionnel∙les du cabinet à savoir les médecins, infirmier∙ères (IMF) et les assistant∙es.médicaux∙ales (AM). Ils se basent sur des données qualitatives issues d’entretiens individuels et de focus groups, recueillies à l’issue de la première et de la deuxième année du pilote
Quality of life in thyroid cancer survivors with and without permanent hypoparathyroidism
No full textHypoparathyroidism (HypoPT) is one of the most common complications of surgical treatment for thyroid cancer and afflicated patients often report symptoms or impairments in quality of life (QoL). We aimed to investigate differences in various QoL domains between thyroid cancer survivors with and without permanent hypoparathyroidism.
Thyroid cancer survivors with a minimum of 1.5 years post-diagnosis completed the EORTC core questionnaire (EORTC QLQ-C30) and the EORTC thyroid module (QLQ-THY34). Sociodemographic and clinical information were obtained from the patients themselves and their medical charts. Analysis of covariance was used to compare QoL between survivors with and without hypoparathyroidism (adjusting for age, gender, time since diagnosis, and comorbidity).
Of the 126 participants, 21 (17%) were diagnosed with permanent HypoPT. There was no evidence of differences regarding any QoL domain between survivors due to hypoparathyroidism. The symptoms with the highest burden for both groups were fatigue (hypoPT: 24.9; non-hypoPT: 32.8; p = 0.151) and insomnia (hypoPT: 22.2; non-hypoPT: 30.8; p = 0.213). Thyroid cancer specific impairments were observed for joint pain (hypoPT: 28.6; non-hypoPT: 34.0; p = 0.480), worry about important others (hypoPT: 25.8; non-hypoPT: 27.9; p = 0.765), exhaustion (hypoPT: 23.8; non-hypoPT: 27.9; p = 0.482), and lacking social support (hypoPT: 36.5; no-hypoPT: 23.0; p = 0.070).
The present study appears to show that QoL in thyroid cancer survivors may be unrelated to hypoparathyroidism, further suggesting a more complex relationship between these two aspects.
© 2025. The Author(s), under exclusive licence to Hellenic Endocrine Society
Clinical value of the MGMT promoter methylation score in IDHmt low-grade glioma for predicting benefit from temozolomide treatment.
No full textDiffuse IDH mutant low-grade gliomas (IDHmt LGG) (World Health Organization grade 2) typically affect young adults. The outcome is variable, with survival ranging from 5 to over 20 years. The timing and choice of initial treatments after surgery remain controversial. In particular, radiotherapy is associated with early and late cognitive toxicity. Over 90% of IDHmt LGG exhibit some degree of promoter methylation of the repair gene O(6)-methylguanine-DNA methytransferase (MGMTp) that when expressed blunts the effect of alkylating agent chemotherapy, for example, temozolomide (TMZ). However, the clinical value of MGMTp methylation predicting benefit from TMZ in IDHmt LGG is unclear.
Patients treated in the EORTC-22033 phase III trial comparing TMZ versus radiotherapy served as training set to establish a cutoff based on the MGMT-STP27 methylation score. A validation cohort was established with patients treated in a single-center first-line with TMZ after surgery/surgeries.
The MGMT-STP27 methylation score was associated with better progression-free survival (PFS) in the training cohort treated with TMZ, but not radiotherapy. In the validation cohort, an association with next treatment-free survival (P = .045) after TMZ was observed, and a trend using RANO criteria (P = .07). A cutoff value set above the 95% confidence interval of being methylated was significantly associated with PFS in the TMZ-treated training cohort, but not in the radiotherapy arm. However, this cutoff could not be confirmed in the test cohort.
While the MGMTp methylation score was associated with better outcomes in TMZ-treated IDHmt LGG, a cutoff could not be established to guide treatment decisions
Screening for Life: Perspectives From Adult Metabolic Specialists on Newborn Screening for Inherited Metabolic Diseases
No full textThe number of inherited metabolic diseases (IMDs) in newborn screening (NBS) programs has increased significantly in the past decades. For some of the IMDs included in NBS (e.g., tyrosinemia type I), there are clear and substantial health benefits of NBS, while for others (e.g., very long chain acyl CoA dehydrogenase deficiency and 3-methylcrotonyl CoA carboxylase 1 deficiency), this is less clear as NBS identifies individuals who are asymptomatic or have milder forms of the disease. Therefore, knowledge of the full disease spectrum (including later onset forms) is needed when setting diagnostic metabolite cut-offs for NBS. Insights into the clinical, genetic and biochemical characteristics of different patient subsets can be used to redefine NBS protocols to identify patients with more severe forms of the disease who are most likely to benefit from identification in the newborn period. These insights require life-long monitoring of individuals identified based on symptoms versus those identified by NBS to determine long-term health outcomes and quantify the benefits of NBS. Adult metabolic specialists should be included in the development of NBS programs to provide data from this long-term monitoring and to contribute specific knowledge about later onset phenotypes of the IMDs included in NBS programs. The goal should be to develop NBS programs that identify newborns that benefit from early disease detection and treatment, without increasing psychological, social and management burden for individuals who may develop disease in adulthood with milder phenotype or potentially even not at all.
© 2025 The Author(s). Journal of Inherited Metabolic Disease published by John Wiley & Sons Ltd on behalf of SSIEM
Frères et sœurs dans l'Antiquité gréco-romaine : réflexions autour d’un lien familial
No full textCet ouvrage a pour objectif principal de dresser un bilan des études conduites jusqu’ici sur la thématique des relations entre frères et sœurs dans l’Antiquité grecque et romaine, en particulier dans les cercles de pouvoir et dans les élites sociales. Des synthèses historiographiques sont proposées sur les quatre dossiers fraternels mixtes les plus connus : Alexandre le Grand et ses sœurs, le couple des souverains lagides Ptolémée II et Arsinoé II Philadelphes, Octave-Auguste et Octavie, l’empereur Caligula et ses trois sœurs . Cependant, l’ouvrage met aussi en lumière d’autres dossiers relatifs aux rapports fraternels, des dossiers moins connus, mais qui méritent aussi l’attention