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Measurement of gastric emptying of a high-nutrient liquid by 3D ultrasonography in diabetic gastroparesis
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Roles of Wnt/B-catenin signalling in methotrexate chemotherapy-induced bone loss and marrow adiposity
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The role of coal combustion products in managing the bioavailability of nutrients and heavy metals in soils
No full textTransforming care : an investigation of the introduction of bedside handover to three rural hospitals
No full textPredominantly, nursing handover is a form of communicating patient information at the shift changeover. While the importance of nursing handover as a communication tool has been widely identified in literature, there has been little written about implementation of this practice. This study explores the introduction of a nurse-to-nurse bedside handover process and is underpinned by Lewin’s 3- Stage Model of Change.
A model for re-education of physiotherapy practitioners to enable return to the workforce
No full textNitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing
No full text1. The present study sought to explain the mechanism leading to reduced availability of propranolol when given after a priming dose in the single-pass perfused rat liver. 2. Extracellular sucrose space (as a measure of sinusoidal relaxation) in perfused rat liver before and after propranolol or propranolol and NG-nitro-l-arginine methyl ester (l-NAME; nitric oxide (NO) synthase inhibitor) treatment were examined. The results showed that propranolol induces sinusoidal relaxation in the perfused liver and this effect could be abolished by NO synthase inhibitor l-NAME. 3. Two bolus injections of propranolol were given to the isolated perfused rat liver and outflow concentration-time profiles of intact propranolol were determined. A two-phase physiologically based organ pharmacokinetic model was applied to estimate hepatocellular influx, efflux, binding, ion-trapping and metabolic elimination pharmacokinetic parameters for propranolol. The recovery of propranolol in the second injection was approximately 54% of that in the first injection. The permeability-surface area product, the binding and the intrinsic clearance all increased significantly after prior exposure of the rat liver to the first bolus of propranolol (P < 0.05). 4. Based on the findings of the present study, we propose that the most likely explanation for the reduced availability of a second propranolol dose (after administration of a priming dose) in the perfused liver is a consequence of the NO-mediated sinusoidal relaxation effect of propranolol, arising from the priming dose. This observation supports the view that the pharmacokinetics of some drugs might be altered by the pharmacodynamic effects of the same drug given earlier in the perfused liver.
Regulating intensity using perceived exertion in spinal cord-injured participants
No full textConclusions: These data suggest that RPE is effective in controlling moderate and vigorous intensities throughout a 20-min handcycling exercise session for SCI participants.