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Characterisation and Developmental Potential of Ovine Bone Marrow Derived Mesenchymal Stem Cells
No full textSince discovery, significant interest has been generated in the potential application of mesenchymal stem cells or multipotential stromal cells (MSC) for tissue regeneration and repair, due to their proliferative and multipotential capabilities. Although the sheep is often used as a large animal model for translating potential therapies for musculoskeletal injury and repair, the characteristics of MSC from ovine bone marrow have been inadequately described. Histological and gene expression studies have previously shown that ovine MSC share similar properties with human and rodents MSC, including their capacity for clonogenic growth and multiple stromal lineage differentiation. In the present study, ovine bone marrow derived MSCs positively express cell surface markers associated with MSC such as CD29, CD44 and CD166, and lacked expression of CD14, CD31 and CD45. Under serum-deprived conditions, proliferation of MSC occurred in response to EGF, PDGF, FGF-2, IGF-1 and most significantly TGF-α. While subcutaneous transplantation of ovine MSC in association with a ceramic HA/TCP carrier into immunocomprimised mice resulted in ectopic osteogenesis, adipogenesis and haematopoietic-support activity, transplantation of these cells within a gelatin sponge displayed partial chondrogenesis. The comprehensive characterisation of ovine MSC described herein provides important information for future translational studies involving ovine MSC. J. Cell. Physiol. 219: 324–333, 2009. © 2008 Wiley-Liss, Inc.
Gender, sexuality and embodiment : access to and experience of healthcare by same-sex attracted women in Australia
No full textThis article identifies the way same-sex attracted women negotiate healthcare in a rural Australian setting. In-depth interviews were conducted with 10 women. Respondents choose general practitioners (GPs) carefully, `interviewing' them to see if they hold acceptable attitudes to same-sex attraction. However, sexuality is not the only evaluative criteria women use. Some women invoke gender-based discourse, evaluating GPs by how well they treat women's bodies. In other instances, women utilize a framework based on sexuality; good healthcare is associated with how the practitioner dealt with same-sex attraction. Sometimes women evaluated care by reference to a model of the body that did not implicate gender or sexuality and GPs are evaluated on the basis of clinical knowledge. This shows that women do not define themselves in a unitary way in relation to gender or sexuality. They selectively and strategically employ discourses of gender, sexuality and embodiment to structure and evaluate healthcare.
Programs for men who perpetrate domestic violence : an examination of the issues underlying the effectiveness of intervention programs
No full textThis review paper seeks to explore some of the reasons why rehabilitation programs for male perpetrators of domestic violence appear to be less effective in reducing recidivism than programs for other offender groups. It is argued that while the model of systems response to domestic violence has predominated at the inter-agency level, further consideration might be given to way in which men’s intervention groups are both designed and delivered. It is concluded that the program logic of men’s domestic violence programs is rarely articulated leading to low levels of program integrity, and that one way to further improve program effectiveness is to incorporate some of the approaches evident in more general violence prevention programs and from what is know about good practice in general about offender rehabilitation.
Life-course socioeconomic position and incidence of coronary heart disease: The Framingham Offspring Study
No full textResilience in re-entering missionaries : why do some do well?
No full textRe-entry to their country of origin is a significant disruption for a number of sojourners including missionaries. Although missionary re-entry has been studied in depth for over 20 years, little is known about what makes a missionary resilient to the challenges experienced in the stressful re-entry environment. Research suggests there are psychological, social, spiritual, and biological constructs connected with resilience. The aim of this paper is to answer the question “Why do some re-entering missionaries do well while others do not?” Fifteen adult Australian Christian cross-cultural missionary workers from four interdenominational Australian evangelical mission organisations completed semi-structured interviews and a survey. Results were analysed in two stages using modified consensual qualitative research methods. Links were established between resilience on re-entry and flexibility, expectancy, self-determination, denial using minimisation, mental health, social support, reintegration and personal spiritual connection with God. Implications for missionary care are discussed with suggestions for further research.
Analysing the hindrances to the reduction of manufacturing lead-time and their associated environmental pollution
No full textAn analysis of workplace representatives, union power and democracy in Australia
No full textThe purpose of this article is to illuminate the views and experiences of workplace representatives in Australia in the context of falling union density, and to analyse factors that are most strongly associated with subjective union power at the workplace level, as perceived by delegates. The analysis relies on a large random survey of workplace delegates in eight significant Australian unions. The article describes the situation broadly facing delegates as shown by the survey and analyses a set of factors associated with the power of workers as perceived by delegates. We find that higher levels of reported activism among delegates are strongly associated with greater subjective union power. We also find that self-reported delegate confidence is also strongly associated with perceptions of higher union power, as is delegate's clarity about their roles. The data also show a strong association between perceptions of democracy within the union and union power. Support for delegates from the union office and organizers is also associated with higher levels of union power at the local level. The analysis provides some support for union renewal strategies associated with the ‘organizing model’ as applied in Australia and some other Anglo-Saxon countries that aim to increase the activism of workplace delegates through education, the provision of support for workplace delegates and more democratic union structures.
