University of South Australia

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    Education to improve cancer care in rural South Australia

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    Cancer management follows the overall trend of rural health disparities, with higher incidence rates of preventable cancers and lower survival rates in rural Australia. Cancer prevention and management has been identified as a priority area and Cancer Australia has funded a variety of innovations throughout Australia. The Rural Chemotherapy Mentoring Program (RCMP) forms part of this drive to improve access to chemotherapy for rural based cancer sufferers in South Australia (SA). The key strategy of this program was the provision of opportunities for rural health clinicians (nurses and GPs) to enhance their knowledge and skills in the delivery of chemotherapy and cancer care through clinical placements at metropolitan oncology units. The RCMP enrolled 43 current SA rural clinicians (five GPs and 38 nurses). This evaluation was undertaken at the end of RCMP’s initial 18 months. It considered how those involved in the RCMP perceived development and delivery of the RCMP, identifying key aspects of the program that were successful. This report emphasises lessons learnt which may be of relevance more widely in the development of other rural health professional education.

    Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation

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    Fetal adaptations to periods of substrate deprivation can result in the programming of glucose intolerance, insulin resistance, and metabolic dysfunction in later life. Placental insufficiency can be associated with either sparing or sacrifice of fetal liver growth, and these different responses may have different metabolic consequences. It is unclear what intrahepatic mechanisms determine the differential responses of the fetal liver to substrate restriction. We investigated the effects of placental restriction (PR) on liver growth and the hepatic expression of SLC2A1, IGF1, IGF2, IGF1R, IGF2R, PPARGC1A, PPARA, PRKAA1, PRKAA2, PCK2, and HSDL1 mRNA in fetal sheep at 140–145 days of gestation. A mean gestational arterial partial pressure of oxygen less than 17 mmHg was defined as hypoxic, and a relative liver of weight more than 2 SD below the mean liver weight of controls was defined as reduced liver growth. Fetuses therefore were defined as control-normoxic (CN; n¼9), PR-normoxic (PR-N; n¼7), PR-hypoxic (PR-H; n¼8), or PR-hypoxic reduced liver growth (PR-H RLG; n ¼ 4). Hepatic SLC2A1 mRNA expression was highest (P , 0.05) in the PR-H fetuses, in which liver growth was maintained. Expression of IGF1 mRNA was decreased (P , 0.05) only in the PR-H RLG group. Hepatic expression of HSDL1, PPARGC1A, and PCK2 mRNA also were increased (P , 0.05) in the PR-H RLG fetuses. The present study highlights that intrahepatic responses to fetal substrate restriction may exist that protect the liver from decreased growth and, potentially, from a decreased responsiveness to the actions of insulin in postnatal life.

    Poverty eradication: lessons from history

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    Match-up revisited: The effect of staff attractiveness on purchase intentions in younger adult females: social comparative and product relevance effects

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    One of the most frequently used promotional strategies is the use of an 'endorser' to promote, advocate or to be the visual representative of the product or brand (Kamins, 1990). The appearance or attractiveness of the endorser has been shown in the literature to be a significant factor in their effectiveness (Ohanian, 1991). However, the literature has not shown whether this effect exists in a context where upward social comparison may occur, such as in a context where interaction with actual staff potentially exists, rather than a celebrity endorser, for example. It was hypothesised in this study that that attractiveness of direct endorsers would significantly increase the purchase decisions of respondents, and that this effect would be improved again when the product was appearance-relevant (i.e a significant interaction effect), based on the match-up hypothesis. Finally, the study examined the effects of social comparison between the respondent and the endorser. Younger females were employed for the study as they were most likely as proposed in the literature to be potentially affected by upward social comparative effects (Strahan, Wilson, Cressman & Buote, 2006). 341 female undergraduate students aged 18-26 were presented with information seeking to assess their purchase intentions of a hypothetical product (either attractive-relevant or not attractive relevant) from a hypothetical salesperson (either attractive or unattractive). Findings of the study indicated that purchase intentions were not significantly higher with attractive salespeople, but that a significant interaction effect existed with product type - in other words purchase intentions were significantly higher for attractive salespeople with an attractive relevant product than in other conditions. Finally, respondents that recorded a higher level of congruence between their appearance and that of the salesperson, negating the potential for upward social comparison, were significantly more likely to indicate higher intentions to purchase. Implications of these findings for current theory, as well as practical implications, are discussed

    (a, k)-anonymous data publishing

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    Re-thinking pragmatics for the classroom: promoting a deductive approach

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