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Incentive and information properties of preference questions : commentary and extensions
No full textThe defence of acquiescence to a breach of trust
No full textThis paper is a comprehensive analysis of the barring of suits by cestuis que trust against their trustees for breach of trust. The defence of acquiescence is examined, with a specific focus on its meaning and constituent elements, after an analysis of the recent decision of the High Court of Australia in Byrnes v Kendle. Through this focus, and a review of relevant English and Australian authorities, this paper deals with issues such as the overlap with other equitable defences and finally a consideration of proposals for a unified doctrine of estoppel and the amalgamation of particular equitable defences under that doctrine.
Optical biosensing for label-free cellular studies
No full textOptical biosensors such as waveguides and surface-plasmon resonance (SPR) sensors have found numerous applications in biomolecular sciences. We provide an overview of these technologies in relation to the specific requirements of label-free and high-throughput cellular studies. We dedicate specific emphasis to SPR-based biosensors and recent developments particularly suitable for cellular studies, such as long-range SPR. We discuss the advantages and the disadvantages of the most successful optical-sensing technologies, and potential approaches in the next generation of optical technologies.
The impact of mandatory corporate governance code of conduct on earnings management : empirical evidence from the Jordanian stock market
No full textResearch proposal (PhD)--University of South Australia, 2014.
The investigation of worked example problems to improve the ability of year 7 students to solve proportional reasoning problems compared to traditional forms of instruction
No full textResearch proposal (PhD)--University of South Australia, 2014.
On the effects of permuted input on conformational sampling of drug-like molecules: an evaluation of stochastic proximity embedding.
No full textConformational sampling is a problem of central importance in computer-aided drug design. A good conformational search method must not exhibit any intrinsic bias, and must provide confidence that important regions of conformational space are not missed during the search. A recent study by Carta et al. showed that this is not always the case, and that several popular conformational search methods, such as Omega, are very sensitive to the relative ordering of atoms and bonds in the connection table. Here, we examine the performance of a newer method known as stochastic proximity embedding, or SPE, using five diverse bioactive ligands extracted from the PDB. Our results confirm that the conformational ensembles produced by SPE using different permuted inputs are statistically indistinguishable, and well within the range of variability that would be expected from the stochastic nature of the method itself. This, along with the results of a more comprehensive comparative study (Agrafiotis et al., J. Chem. Info. Model, 2007, in press), provides further evidence that SPE is one of the most robust and competitive conformational search methods described to date.
On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa
No full textRetinitis pigmentosa (RP), the hereditary degenerative disease of the photoreceptor neurons of the retina, probably represents the most prevalent cause of registered blindness amongst those of working age in developed countries. Mutations within the gene encoding inosine monophosphate dehydrogenase 1 (IMPDH1), the widely expressed rate-limiting enzyme of the de novo pathway of guanine nucleotide biosynthesis, have recently been shown to cause the RP10 form of autosomal dominant RP. We examined the expression of IMPDH1, IMPDH2 and HPRT transcripts, encoding enzymes of the de novo and salvage pathways of guanine nucleotide biosynthesis, respectively, in retinal sections of mice, the data indicating that the bulk of GTP within photoreceptors is generated by IMPDH1. Impdh1(-/-) null mice are shown here to display a slowly progressive form of retinal degeneration in which visual transduction, analysed by electroretinographic wave functions, becomes gradually compromised, although at 12 months of age most photoreceptors remain structurally intact. In contrast, the human form of RP caused by mutations within the IMPDH1 gene is a severe autosomal dominant degenerative retinopathy in those families that have been examined to date. Expression of mutant IMPDH1 proteins in bacterial and mammalian cells, together with computational simulations, indicate that protein misfolding and aggregation, rather than reduced IMPDH1 enzyme activity, is the likely cause of the severe phenotype experienced by human subjects. Taken together, these findings suggest that RP10 may represent an attractive target for therapeutic intervention, based upon a strategy combining simultaneous suppression of transcripts from normal and mutant IMPDH1 alleles with supplementation of GTP within retinal tissues.
World Health Organization Bulletin Round Table [Folder Title]
No full textThis folder contains correspondence between Hetzel and The World Health Organization on his paper “The role of the International Council for Control of Iodine Deficiency Disorders in the global partnership for the elimination of iodine deficiency as a cause of brain damage.”
Elimination of iodine deficiency in China [Folder Title]
No full textThis folder contains documents between Hetzel and Chinese doctors on the elimination of iodine deficiency in China. Documents include: correspondence between Chinese doctors and Hetzel on his speech at the Great Hall of the People in Beijing; speech made by Hetzel to the “Celebration of Success in Elimination of Iodine Deficiency disorders in the Great Hall of the People Beijing 27 October 2000.”
Half a Century of healthcare in Australia
No full textThis item is a journal article submitted by Basil Hetzel and Stephen R. Leeder to the Medical Journal of Australia on the health service currently existing within Australia. Particular focus of the article is on the poor health standards of Indigenous Australians.