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Designaciones populares de nubes que cubren montañas en refranes meteorológicos romances
Get PDFSe ofrece un estudio sobre designaciones populares de nubes que cubren montañas y de los tipos parémicos (o paremiotipos) correspondientes en el ámbito romance. La estructura de tales refranes meteorológicos, en general bimembre, aloja en su primera parte las denominaciones específicas de ese tipo de nubes, que en general responden a metáforas referidas a la cabeza o el cuerpo humanos (predominan los representantes de la familia léxica del latín CAPPA y derivados). En una segunda parte, el enunciado concreto de cada predicción responde a fórmulas diversas, entre las que predominan los consejos sobre abrigo o refugio. Cabe destacar las significativas afinidades interromances (con la esperable salvedad del ámbito rumano). Por ello se propone la concepción de un continuum románico relativo también a los refranes: lo que propongo denominar 'Romania parémica continua'
Queer futurities: Artistic strategies for dynamization of archives
Get PDF"Gendernaut. Queering the future" is a project clearly influenced by queer theories, transfeminist activism and science fiction. It displays a reflection on the potential of various strategies related to accessibility, distribution, socialization and playful reinterpretation of feminist and queer archives. The creation of archives, software programming, audiovisual production, performing performances or developing games thus become artistic strategies for energizing archives, and have a clear desire to make archives that address the memory of people more accessible. feminisms and dissidents of gender and sexuality. Through transmedia and performative experiences, we conceive the archive as a living interactive space, free of heteropatriarchal codes, inhabited by multiple bodies and subjectivities that relate past, present and future to come
RNase H-sensitive multifunctional ASO-based constructs as promising tools for the treatment of multifactorial complex pathologies
Get PDFCombined therapies play a key role in the fight against complex pathologies, such as cancer and related drug-resistance issues. This is particularly relevant in targeted therapies where inhibition of the drug target can be overcome by cross-activating complementary pathways. Unfortunately, the drug combinations approved to date –mostly based on small molecules– face several problems such as toxicity effects, which limit their clinical use. To address these issues, we have designed a new class of RNase H-sensitive construct (3ASO) that can be disassembled intracellularly upon cell entry, leading to the simultaneous release of three different therapeutic oligonucleotides (ONs), tackling each of them the mRNA of a different protein. Here, we used Escherichia coli RNase H1 as a model to study an unprecedented mode of recognition and cleavage, that is mainly dictated by the topology of our RNA·DNA-based hybrid construct. As a model system for our technology we have created 3ASO constructs designed to specifically inhibit the expression of HER2, Akt and Hsp27 in HER2+ breast cancer cells. These trifunctional ON tools displayed very low toxicity and good levels of antiproliferative activity in HER2+ breast cancer cells. The present study will be of great potential in the fight against complex pathologies involving multiple mRNA targets, as the proposed cleavable designs will allow the efficient single-dose administration of different ON drugs simultaneously
¿Qué tratamiento fiscal otorgar al disfrute gratuito de bienes de la sociedad por el socio?
Get PDFUna de las preguntas que surgen con más frecuencia cuando se analizan las relaciones económicas entre una sociedad y sus socios, especialmente, si
son socios mayoritarios o únicos, es la de determinar cuál es el tratamiento en el Impuesto sobre la Renta de las Personas Físicas del socio del derecho
a disfrutar y a utilizar de forma gratuita de bienes titularidad de la sociedad o cuyo derecho de uso se ha atribuido a la sociedad (por un contrato de leasing o de renting, por ejemplo)
Intrasalt carbonates in the Estopanyà Salt Wall (South-Central Pyrenees): reservoir quality and implications for geothermal exploration in salt diapirs
Get PDFStringers are disrupted rock bodies commonly enclosed within salt diapirs. Traditionally, they have been regarded as a risk factor in the energy exploitation of salt structures due to their heterogeneity and general sub-seismic scale, which hinder their detailed identification. Nevertheless, rock units in stringers may exhibit sufficient permeability and temperature to act as potential reservoirs, for instance, in geothermal energy. Despite this possibility, studies regarding the reservoir potential of intrasalt stringers remain scarce.The well-exposed Estopanyà Salt Wall in the South-Central Pyrenees contains abundant Muschelkalk carbonate stringers, providing an excellent opportunity to study the geological controls on their reservoir properties. Four lithofacies within two stratigraphic intervals were identified. Depositional lithofacies (DLF-1 and DLF-2) preserve original rock textures, whereas alteration lithofacies (ALF-1 and ALF-2) result from intense brecciation, cementation, and dolomitization-dedolomitization affecting the depositional facies. Thermophysical analyses of 30 samples reveal limited variation in mineral density (2.61–3.00 g cm−3), bulk density (1.92–2.95 g cm−3), and thermal conductivity (2.37–3.48 W m−1 K−1), with the latter being primary controlled by rock mineralogy. In contrast, connected porosity (0.33–29.20 %), permeability (−18–10−14 m2), P-wave velocity (3.7–6.4 km s−1 dry; 3.7–6.5 km s−1 saturated conditions), and specific heat capacity (640–804 J kg−1 K−1) show greater variability. Property cross-plots indicate that porosity percentage and distribution are the main factors controlling the observed thermophysical behavior, which is ultimately linked to rock texture.The area and scarce thickness of porous and permeable intervals (estimated at reservoir volumes of 0.14–4.6 km3), likely preclude the limited reservoir use of the studied stringers. However, petrographic evidence from them highlights interesting processes such as brecciation and dolomitization that may have enhanced the permeability and thermal conductivity in the past, while subsequent cementation and dedolomitization reduced reservoir quality. Accordingly, although current outcrop conditions show diminished reservoir potential, higher porosity-permeability values may be preserved in the subsurface.Overall, this study establishes a conceptual model for the geological controls, limitations, and potential of intrasalt carbonates as unconventional reservoirs, providing comprehensive petrological and thermophysical data that can guide their exploration for geothermal production in salt diapir settings
La mobilitazione internazionalista, il caso della guerra di Spagna
Get PDFAfter a brief, general reflection on the rich literature and the historiographic debates concerning the internationalist mobilization and the Spanish War, the article will briefly analyse four aspects. Firstly, it will take into consideration the Comintern’s interpretation of the Spanish situation before the Civil War and the reasons that led to a resolute effort towards the defence of the Spanish republic menaced by the golpe carried out in the Summer of 1936. That effort, a part of the Popular Fronts’ strategy, had some characteristics that spread decisively the image of a Communist movement committed to the defence of democracy. Secondly, the Comintern action during the war will be analysed. T he focus will be on the building of the International Brigades, especially the leadership and organizational structure developed in order to realise an original effort of international solidarity, and their military action at Jarama, Guadalajara, Brunete, Belchite, Teruel, Aragon, and Ebro, before their dissolution and the retreat of the foreign soldiers, which took place in November 1938. The article will also examine the Comintern political action and that of its leaders within republican political life, especially the conflict of Spring 1937. Lastly, the article will focus on the memory of the Comintern and International Brigades’ action, especially during the Cold War
On the elusive formalisation of the risky condition for hypothesis testing
Get PDFIn this paper, we examine possible formalisations of the riskiness condition for hypothesis testing. First, we informally introduce derivability and riskiness as testing conditions together with the corresponding arguments for refutation and confirmation. Then, we distinguish two different senses of confirmation and focus our discussion on one of them with the aid of a historical example. In the remaining sections, we offer a brief overview of the main references to the risky condition in the literature and scrutinise different options for formally capturing riskiness; we show why none of them works. We conclude with some remarks about the relation between derivability and riskiness and claim that riskiness essentially involves a contextual, pragmatic component that eludes a complete formal reconstruction
Walnut-enriched diet increases the association of LDL from hypercholestero lemic men with human HepG2 cells
Get PDFIn a randomized, cross-over feeding trial involving 10 men with polygenic hypercholesterolemia, a control, Mediterranean-type cholesterol-lowering diet, and a diet of similar composition in which walnuts replaced approximately 35% of energy from unsaturated fat, were given for 6 weeks each. Compared with the control diet, the walnut diet reduced serum total and LDL cholesterol by 4.2% (P = 0.176), and 6.0% (P = 0.087), respectively. No changes were observed in HDL cholesterol, triglycerides, and apolipoprotein A-I levels or in the relative proportion of protein, triglycerides, phospholipids, and cholesteryl esters in LDL particles. The apolipoprotein B level declined in parallel with LDL cholesterol (6.0% reduction). Whole LDL, particularly the triglyceride fraction, was enriched in polyunsaturated fatty acids from walnuts (linoleic and alpha-linolenic acids). In comparison with LDL obtained during the control diet, LDL obtained during the walnut diet showed a 50% increase in association rates to the LDL receptor in human hepatoma HepG2 cells. LDL uptake by HepG2 cells was correlated with alpha-linolenic acid content of the triglyceride plus cholesteryl ester fractions of LDL particles (r(2) = 0.42, P < 0.05). Changes in the quantity and quality of LDL lipid fatty acids after a walnut-enriched diet facilitate receptor-mediated LDL clearance and may contribute to the cholesterol-lowering effect of walnut consumption
Grup de filosofia analítica
Get PDFEl Grup de Filosofia Analítica forma part de la Societat Catalana de Filosofia, entitat filial de l’Institut d’Estudis Catalans. Es va constituir l’any 2002 amb la voluntat de contribuir a la difusió de l’enfocament i els estàndards d’argumentació propis de la tradició analítica en filosofia. El que caracteritza el corrent analític en filosofia no és ni la temàtica que es tracta (es tracten qüestions en qualsevol de les àrees de la filosofia: metafísica, filosofia de la lògica, ètica, filosofia de la ment, filosofia del llenguatge, epistemologia, filosofia política, etc.), ni les tesis que es defensen (per a gairebé qualsevol tipus de problema filosòfic hi ha filòsofs analítics que defensen postures incompatibles entre si), sinó el tipus d’enfocament que s’adopta
Teachers joint planning as a field of learning and professional development
Get PDFAunque muchas propuestas de desarrollo profesional docente reconocen el valor formativo de las situaciones del lugar de trabajo, suelen ser escasos los estudios que exploran en detalle lo que realmente ocurre cuando los maestros trabajan juntos en tareas habituales de su práctica. Este trabajo estudia las formas de actividad conjunta entre dos maestras, una recién llegada a una escuela y la otra con diversos años de permanencia en la misma, en las sesiones de coordinación de nivel habituales, donde planifican el trabajo de sus respectivos grupos clase. El estudio se aborda desde una estrategia metodológica de estudio de caso. Se realiza un análisis de interactividad y un análisis de contenido de las conversaciones registradas en audio. Los resultados muestran las sesiones de planificación entre maestras como un ámbito en el que les es posible conversar y construir conjuntamente conocimiento sobre las situaciones de su práctica y desarrollarse profesionalmente. Ambas maestras construyen la actividad de planificación focalizándola en la selección y caracterización compartida de tareas de enseñanza y aprendizaje específicas que se representan, gracias al discurso, como “sistemas de actividad situada”. Estos resultados tienen implicaciones relevantes para el diseño y desarrollo del aprendizaje continuado del profesorado en el lugar de trabajo