276557 research outputs found
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European Cancer Organisation Essential Requirements for Quality Cancer Care for ovarian cancer: Focus on the multidisciplinary team.
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316373.pdf (Publisher’s version ) (Open Access)European Cancer Organisation Essential Requirements for Quality Cancer Care (ERQCC) are written by experts representing all disciplines involved in cancer care in Europe. They give patients, health professionals, managers and policymakers a guide to essential care. Here, the essential requirements to treat ovarian cancer patients are described. Ovarian cancer patients continue to have low cure rates with wide variation in treatment and care in Europe and beyond. They require complex treatment that should be carried out in specialised ovarian/gynaecological cancer centres by professionals with the appropriate expertise interacting in a multidisciplinary team. Such centralisation is still not well established in many European countries. A patient-centred pathway from diagnosis through treatment to survivorship, managed in dedicated centres, is key to achieving optimal care and a successful clinical outcome.01 februari 202
Search for the associated production of charm quarks and a Higgs boson decaying into a photon pair with the ATLAS detector
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317153.pdf (Publisher’s version ) (Open Access
Rehabilitation and Capability care in NeuroMuscular Diseases
No full textItem does not contain fulltextIn this Data Acquisition Collection data collected for the Rehabilitation and Capability Care in NeuroMuscular Diseseas (ReCap-NMD) study are stored. In this DAC, the quantitative raw data and SPSS syntaxes for analyses of the primary and secondary outcome measures of this study can be found. With these analyses, the effectiveness of capability care (care based on the capability approach) for persons with neuromuscular diseases is evaluated, compared to usual care for persons with NMD
Reply to Buzón-Martín and Troya
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317921.pdf (Publisher’s version ) (Closed access
The teacher guidance model for practitioner research: A longitudinal case study
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310586.pdf (Publisher’s version ) (Open Access)This study investigated whether and how a teacher guidance model could be applied by researchers to guide Dutch elementary school teachers in learning to conduct practitioner research. The authors' guidance model is inspired by the cognitive apprenticeship approach and comprises four phases with different guidance strategies to scaffold and fade support for teacher learning. Over the course of three years, two researchers facilitated four teacher teams (7-11 members per team) during three phases of the model. The researchers and teachers both appraised the guidance strategies; teachers also rated their proficiency in conducting practitioner research before and after each phase. Results showed that teachers' confidence increased and that they considered the guidance strategies valuable. Thus, the teacher guidance model provides a good starting point for researchers aiming to support teachers in learning to conduct practitioner research. Future research should aim to refine the guidance strategies within the model.20 p
foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations.
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317354.pdf (Publisher’s version ) (Open Access)BACKGROUND: FOXE1 mutations in humans are associated with cleft palate and hypothyroidism. We previously developed a foxe1 mutant zebrafish demonstrating mineralization defects in larvae. In the present study, we investigate the thyroid status and skeletal phenotype of adult foxe1 mutants. RESULTS: Mutant fish have increased expression of tshβ in the pituitary, and of hepatic dio1 and dio2. In plasma, we found higher Mg levels. Together these findings are indicative of hypothyroidism. We further observed mineralization defects in scales due to enhanced osteoclast activity as measured by increased expression levels of tracp, ctsk, and rankl. Gene-environment interactions in the etiology of FOXE1-related craniofacial abnormalities remain elusive, which prompts the need for models to investigate genotype-phenotype associations. We here investigated whether ethanol exposure increases the risk of developing craniofacial malformations in foxe1 mutant larvae that we compared to wild types. We found in ethanol-exposed mutants an increased incidence of developmental malformations and marked changes in gene expression patterns of cartilage markers (sox9a), apoptotic markers (casp3b), retinoic acid metabolism (cyp26c1), and tissue hypoxia markers (hifaa, hifab). CONCLUSION: Taken together, this study shows that the foxe1 mutant zebrafish recapitulates phenotypes associated with FOXE1 mutations in human patients and a clear foxe1-ethanol interaction
ERN eUROGEN Guidelines on the Management of Anorectal Malformations, Part IV: Organization of Care and Communication between Providers.
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318084.pdf (Publisher’s version ) (Open Access)INTRODUCTION: Being born with an anorectal malformation (ARM) can have profound and lifelong implications for patients and parents. Organization of care and communication between health care providers is an overlooked area of patient care. The European Reference Network eUROGEN for rare and complex urogenital conditions assembled a panel of experts to address these challenges and develop comprehensive guidelines for the management of ARM. METHODS: The Dutch Quality Standard for ARM served as the basis for the development of guidelines. Literature was searched in Medline, Embase, and Cochrane. The ADAPTE method was utilized to incorporate the newest available evidence. A panel of 15 experts from seven European countries assessed currency, acceptability, and applicability of recommendations. Recommendations from the Dutch Quality Standard were adapted, adopted, or rejected and recommendations were formed considering all available evidence, expert consensus, and the European context. RESULTS: Aspects pertaining to organization of care, patient/parent/health care provider communication, and referral and collaboration between providers caring for ARM patients were assessed. Two new studies were identified. In total, the panel adapted 12 recommendations, adopted 7, and developed 2 de novo. The overall level of newly found evidence was considered low and most recommendations were based on expert opinion. CONCLUSION: Collaborative care and organization of care are gaining importance in the field of ARM. This guideline gives practical guidance on how to achieve better communication and collaboration between all involved parties, applicable at the European level.01 april 202
The rise and fall of promises: a preliminary method to trace promises in science and technology
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315262.pdf (Publisher’s version ) (Open Access
Early literacy development in the Dutch Caribbean: The role of Papiamento
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312426.pdf (Publisher’s version ) (Open Access)Radboud University, 08 januari 2025Promotores : Verhoeven, L.T.W., Segers, P.C.J., Severing, R.E.235 p
Learning Strategy with Barlow Twins Objective for Emotion-Robust Speaker Verification System
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318169.pdf (Publisher’s version ) (Open Access)ICASSP 202