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Lumbar Multifidus Dysfunction and Chronic Low Back Pain: Overview, Therapies, and an Update on the Evidence.
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319490.pdf (Publisher’s version ) (Open Access)BACKGROUND: Chronic low back pain (CLBP) is a common and harmful medical condition, and in many cases, no specific radiographic cause is identified. Many cases of CLBP are refractory to treatment and will recur after the initial episode. Dysfunction of the lumbar multifidus muscle (LMM) has been increasingly identified as a possible cause of non-specific CLBP (NSCLP). METHODS: A review was conducted on the multifidus anatomy, dysfunction, diagnosis, and treatment literature. RESULTS: Multifidus dysfunction has been increasingly recognized as a potential contributor to the pathogenesis of non-specific chronic low back pain. Multifidus dysfunction is thought to arise from reflex inhibition stemming from an initial insult, which decreases spinal stability and predisposes patients to further injury. Therapeutic approaches aimed at addressing multifidus dysfunction include traditional conservative management, such as patient education, non-steroidal anti-inflammatory drugs, spinal manipulation, and physical therapy. These therapies aim mainly to achieve pain relief. Treatments that restore natural multifidus function include motor control exercises and restorative neurostimulation. CONCLUSION: Non-specific chronic low back pain is correlated with multifidus atrophy, fatty infiltration, and abnormal lumbar multifidus muscle function. This finding highlights the need for further research and clinical trials on targeted therapeutic approaches. Existing treatments on the lumbar multifidus muscle include motor control exercises and restorative neurostimulation. Unlike many conventional treatments that primarily provide symptom relief, these therapies aim to restore natural multifidus function, offering a rehabilitative rather than purely palliative approach. Motor control exercises have been shown to improve symptoms in cases of CLBP, but there is mixed evidence of their effectiveness relative to standard physical therapy. Restorative neurostimulation is a promising intervention that has been shown to provide significant, durable improvements to disability and pain. Further research on restorative therapies should be conducted using rigorous control protocols and comparative analyses with other CLBP treatment modalities.01 juni 202
A multifrequency study of sub-parsec jets with the Event Horizon Telescope
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318900.pdf (Publisher’s version ) (Open Access
Ultra-broadband coherent open-path spectroscopy for multi-gas monitoring in wastewater treatment
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318913.pdf (Publisher’s version ) (Open Access
Shared Communal Identities in a Changing Religious World: The cases of Hatra and al-Hira
No full textItem does not contain fulltextIdentität und Zugehörigkeit: Gelebte Religion im Übergang von Polytheismus zu monotheistischen Religionen, 19 juni 202
Dinosaur in a Haystack: X-Ray View of the Entrails of SN 2023ixf and the Radio Afterglow of Its Interaction with the Medium Spawned by the Progenitor Star (Paper I)*
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319389.pdf (Publisher’s version ) (Open Access
Targeted long-read sequencing analysis and antifungal susceptibility profiles of Sporothrix schenckii isolates from Thailand.
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321004.pdf (Publisher’s version ) (Open Access)Sporothrix spp. are dimorphic fungi capable of undergoing morphological changes in response to temperature variations. The genus Sporothrix includes the species S. schenckii sensu stricto, S. brasiliensis, S. globosa, and S. luriei that cause sporotrichosis, which can range from local skin infections to systemic infections in immunocompromised individuals. As these species are morphologically similar, molecular techniques that utilize barcoding genes are required for accurate identification. While the Internal Transcribed Spacer (ITS) region is the universal fungal barcode, the calmodulin gene offers higher resolution for phylogenetic classification of Sporothrix using Sanger sequencing. This study evaluated the ability of long-read nanopore sequencing of calmodulin and ITS to identify species level and allow phylogenetic analysis of Sporothrix strains isolated from humans and felines in Thailand. We found that the calmodulin sequencing with Oxford Nanopore Technology (ONT) consistently classified all isolates as S. schenckii sensu stricto, whereas the ITS region showed a lower discriminatory power, complicating species identification in some isolates. The phylogenetic analysis of the calmodulin region indicated that all isolates localized in a specific S. schenckii sensu stricto subclade together with other isolates from Southeast Asia, while the three residual S. schenckii subclades were associated with other geographical locations. Antifungal susceptibility testing on all Sporothrix strains demonstrated elevated in vitro minimum inhibitory concentrations (MICs) to itraconazole for 8 out of 26 isolates. Altogether, this study demonstrated that ONT sequencing of calmodulin allows accurate species identification and phylogenetic analysis of S. schenckii sensu stricto isolates from Thailand, of which some also demonstrated elevated MIC values for itraconazole.01 juni 202
The Emperor's New Reporting Guidelines: Are We Fooling Ourselves?
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319066.pdf (Publisher’s version ) (Open Access
Interleukin-6 modifies Lipoprotein(a) and oxidized phospholipids associated cardiovascular disease risk in a secondary prevention cohort
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320891.pdf (Publisher’s version ) (Open Access)BACKGROUND AND AIMS: There is a need for effective tools to stratify and modify cardiovascular risk associated with elevated lipoprotein(a) [Lp(a)] and oxidized phospholipids (OxPL). The objective of this analysis was to explore the modifying effects of low-grade inflammation on Lp(a)- and OxPL-associated risk in a secondary prevention cohort. METHODS: Levels of Lp(a), OxPL associated with apolipoprotein(a) (OxPL-apo[a]) and apolipoprotein B (OxPL-apoB) were determined in the placebo-arm of the low-dose colchicine 2 trial. Patients were between 35 and 82 years, had established chronic coronary syndrome (CCS), and were clinically stable for at least six months prior to randomization. The outcome was the incidence of the composite endpoint of spontaneous myocardial infarction, ischemic stroke, or ischemia-driven coronary revascularization stratified by biomarker levels using a Cox regression model. RESULTS: There was a significant interaction between Lp(a) and IL-6 <3.2 ng/L (median) and IL-6 ≥3.2 ng/L for the composite endpoint (HR 0.90; 95 %CI 0.78-1.03 vs HR 1.18; 95 %CI 1.01-1.39, P(interaction) = 0.01). No interaction was found for Lp(a) levels in participants with hsCRP <2 mg/L (HR 1.00; 95 %CI 0.89-1.14) versus those with hsCRP ≥2 mg/L (HR 1.04; 95 %CI 0.86-1.25, P(interaction) = 0.79). In line with Lp(a) levels, significant interaction was observed between OxPL-apo(a) as well as OxPL-apoB levels for the composite endpoint with IL-6 (P(interaction)<0.01 and 0.03, respectively), but not for hsCRP. CONCLUSIONS: In patients with CCS, Lp(a), OxPL-apo(a) and OxPL-apoB associated cardiovascular risk was only pertinent in those with elevated IL-6 but not hsCRP levels
Food quality assessment and quantification using multispectral images from screen and smartphone for kiwifruit ripeness and rice discrimination
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319275.pdf (Publisher’s version ) (Open Access
Tom Van de Voorde dicht verrassend persoonlijk over verloren vriendschap
No full textItem does not contain fulltext19 juni 202