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The Effect of Lifestyle on the Quality of Life of Vulvar Cancer Survivors.
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318045.pdf (Publisher’s version ) (Open Access)Introduction: Vulvar cancer affects approximately 47,000 women annually worldwide. With most studies focusing on oncological outcomes, quality of life is often overlooked. There is a lack of knowledge on the influence of modifiable factors such as lifestyle on the quality of life of vulvar cancer survivors. This study evaluated the association between lifestyle factors and the quality of life of vulvar cancer survivors. Methods: This was a cross-sectional survey study of women who received surgical treatment for vulvar cancer ≥FIGO stage 1B at the Northern Gynecological Oncology Centre, UK, between 2013 and 2022. Baseline and clinical characteristics were collected from patient records. Godin Leisure-Time Exercise questionnaires were used to assess physical activity. BMI was assessed using self-reported height and weight. Quality of life was measured using the validated European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) and the vulvar cancer-specific module (VU-34). An analysis was performed using Mann-Whitney-U and Kruskal-Wallis tests. Results: Of the 299 women, 139 were eligible for participation, of whom 58 participated (41.7%). Twenty participants had a sedentary (40.8%), eight a moderately active (16.3%), and seventeen an active (34.7%) lifestyle. Active participants reported higher overall quality of life and higher functioning in all domains but not for vulvar-related symptoms or sexual functioning. Forty-nine participants disclosed their BMI, which was not associated with quality of life outcomes. Conclusions: A higher level of physical activity was associated with higher quality of life. No association was found between BMI and quality of life
Insights from Univalent Foundations: A Case Study Using Double Categories
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317293.pdf (Publisher’s version ) (Open Access)CLS 202
Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units-the SAFE-ICU study.
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317619.pdf (Publisher’s version ) (Closed access)PURPOSE: Appropriate antifungal therapy is a major determinant of survival in critically ill patients with invasive fungal disease. We sought to describe whether contemporary dosing of antifungals achieves therapeutic exposures in critically ill patients. METHODS: In a prospective, open-label, multicenter pharmacokinetic study, intensive care unit (ICU) patients prescribed azoles, echinocandins, or polyene antifungals for treatment or prophylaxis of invasive fungal disease were enrolled. Blood samples were collected on two occasions, with three samples taken during a single dosing interval on each occasion. Total concentrations were centrally measured using validated chromatographic methods. Pharmacokinetic parameters were estimated using noncompartmental methods. Antifungal dosing adequacy was assessed using predefined PK/PD targets. RESULTS: We included 339 patients from 30 ICUs across 12 countries. Median age 62 (interquartile range [IQR], 51-70) years, median APACHE II score 22 (IQR, 17-28), and 61% males. Antifungal therapy was primarily prescribed for treatment (80.8%). Fluconazole was the most frequently prescribed antifungal (40.7%). The most common indication for treatment was intra-abdominal infection (30.7%). Fungi were identified in 45% of patients, of which only 26% had a minimum inhibitory concentration available. Target attainment was higher for patients receiving prophylaxis (> 80% for most drugs). For patients receiving treatment, low target attainment was noted for voriconazole (57.1%), posaconazole (63.2%), micafungin (64.1%) and amphotericin B (41.7%). CONCLUSION: This study highlights the varying degrees of target attainment across antifungal agents in critically ill patients. While a significant proportion of patients achieved the predefined PK/PD targets, wide variability and subtherapeutic exposures persist. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03136926, 2017-04-21.01 februari 202
Arbitration in the Netherlands, in particular NAI arbitration
No full textItem does not contain fulltextXXIII, 665 p
Multisensory contextual cues and information affect plant-based food choices and taste perception
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314210.pdf (Publisher’s version ) (Open Access)The context in which food is selected and consumed is an important factor in its choice, consumption, and acceptability. This study assessed the effect of information and multisensory contexts on meat-related food choices and taste perception. In total, 224 participants first watched one of two pitches, either discussing the implications of consuming animal meat (sustainable pitch) or promoting body movement (control pitch). Participants were then exposed to one of three multisensory contexts: a 'sustainable' context with natural green colours, nature sounds and a flower fragrance, a 'meat' context with red colours, the sounds of country music and a smokey BBQ smell, and a monotone off-white ‘neutral’ context with neutral background music and no additional smell. Participants were instructed to choose one of two presented hotdogs (animal meat hotdog or plant-based meat hotdog) and to taste and rate the chosen one on liking and taste attributes. Results showed that multisensory sustainable contextual cues combined with information on sustainability beforehand increased the likelihood of choosing plant-based meat hotdogs over animal meat hotdogs. In addition, while tasting the plant-based meat hotdog, multisensory contextual cues that are inspired by a meat context appeared to enhance taste perception, even for vegans and vegetarians. These findings provide further evidence for the importance of context in food choice and acceptance: the context where people choose plant-based meat should preferably be separated and different from the context of consumption. The findings also imply that information can change behaviour, not just attitudes as previous research indicated, but only if combined with multisensory cues in the context.11 p
An in-depth dataset of northwestern European arthropod life histories and ecological traits
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317947.pdf (Publisher’s version ) (Open Access)17 p
Learning the painful way: The role of pain in psychopathy, decision-making and empathy
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317826.pdf (Publisher’s version ) (Open Access)Psychopathy is associated with manipulativeness, lack of empathy, impulsivity, and antisocial behavior. Current models suggest that these traits may stem from deficits in learning from punishments. This thesis explored pain sensitivity, learning from painful outcomes and empathy in psychopathy. In Chapter 2, I demonstrated that some personality traits reduce sensitivity to certain types of pain. In Chapters 3 and 4 I showed that people with higher psychopathic traits are less affected by the pain and distress of others because they experience their own emotions and pain less intensely. Finally, in Chapters 5 and 6, I used EEG and computational models to study how people learn from pain and rewards. Those with high psychopathic traits struggled to integrate past experiences and learn from painful outcomes due to reduced pain sensitivity. However, certain psychopathic traits improved learning from tailored rewards. These findings suggest psychopathy might involve a disconnect between learning from rewards and punishments but tailoring rewards may help address some decision-making deficits. Overall, the observed difficulties with pain empathy, pain sensitivity, and learning indicate that people with high psychopathic traits struggle to feel pain, understand others' pain, and learn from painful experiences, both their own and others'.Radboud University, 14 april 2025Promotor : Oosterman, J.M. Co-promotor : Brazil, I.A.267 p
Mitochondrial dysfunction drives a neuronal exhaustion phenotype in methylmalonic aciduria
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317748.pdf (Publisher’s version ) (Open Access)17 p
Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies.
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318013.pdf (Publisher’s version ) (Open Access)Background/Objectives: Most individuals who have a familial or clinical risk of developing psychosis remain free from psychopathology. Identifying neural markers of resilience in these at-risk individuals may help clarify underlying mechanisms and yield novel targets for early intervention. However, in contrast to studies on risk biomarkers, studies on neural markers of resilience to psychosis are scarce. The current study aimed to identify potential brain markers of resilience to psychosis. Methods: A systematic review of the literature yielded a total of 43 MRI studies that reported resilience-associated brain changes in individuals with an elevated risk for psychosis. Label-based meta-analysis was used to synthesize findings across MRI modalities. Results: Resilience-associated brain changes were significantly overreported in the default mode and language network, and among highly connected and central brain regions. Conclusions: These findings suggest that the DMN and language-associated areas and central brain hubs may be hotspots for resilience-associated brain changes. These neural systems are thus of key interest as targets of inquiry and, possibly, intervention in at-risk populations
Comparison of dermal and eschar fibroblasts in full skin equivalents.
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316627.pdf (Publisher’s version ) (Open Access)Full-thickness burn wounds pose significant problems, demanding specialised therapies to avoid complications and promote recovery. Eschar tissue, which forms in response to severe burns, contains viable fibroblasts, which migrate from the surrounding tissue in response to burn injury and exhibit a myofibroblast phenotype. The goal of this study was to characterise eschar-derived fibroblasts and examine their use for engineered in vitro full skin equivalents in comparison to normal dermal fibroblasts, which were harvested from non-injured skin. Microarray analysis indicated that eschar fibroblasts differ from dermal fibroblasts in various biological processes including inflammation, extracellular matrix formation, cell migration and differentiation. Skin equivalents with eschar fibroblasts showed similarities to those generated using normal dermal fibroblasts in terms of epidermis and dermis formation. However, in contrast to dermal fibroblast-based full skin equivalents, eschar fibroblast-based equivalents exhibited macroscopic contractile behaviour. In addition, eschar fibroblasts-based equivalents demonstrated higher alpha-smooth muscle actin expression on mRNA and protein levels. In conclusion, our findings suggest that eschar fibroblasts-based full skin equivalents hold promise as a platform to study burn wound environments as eschar fibroblasts are clinically more relevant fibroblasts and able to mimic certain aspects of the challenging wound environment in vitro