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Microbial scents: Soil microbial Volatile Organic Compounds (mVOCs) as biomarkers for grasslands across a land use gradient
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317193.pdf (Publisher’s version ) (Open Access
Dataset Shape transformations in peptide-DNA coacervates driven by enzyme-catalyzed deacetylation
No full textItem does not contain fulltextBiomolecular condensates formed by liquid-liquid phase separation (LLPS) are important organizers of biochemistry in living cells. Condensate formation can be dynamically regulated, for example by protein binding or enzymatic processes. However, how enzymatic reactions can influence condensate shape and control shape transformations is less well understood. Here, we design a model condensate that can be formed by the enzymatic deacetylation of a small peptide by sirtuin-3 in the presence of DNA. Interestingly, upon nucleation condensates initially form gel-like aggregates that gradually transform into spherical droplets, displaying fusion and wetting. This process is governed by sirtuin-3 concentration, as more enzyme resulted in a faster aggregate-to-viscous liquid transformation of the condensates. We show that the aggregate-like nature of the early-stage condensates is linked to the presence of short, double-stranded DNA. The counterintuitive formation of aggregate-like, non-spherical condensates near the critical point is attributed to stronger bending of the DNA by oppositely charged peptides as the system moves away from the critical point, deeper in the two-phase region. Overall, this work shows that enzymes can induce shape transformations of condensates, and that condensate material properties do not necessarily inform about their stability. In this collection, you can find the data underlying this study
Famine and 'hongersnood' as transnational memory. Literary legacies of the 1840s food crises in Ireland and the Netherlands
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311592.pdf (Publisher’s version ) (Open Access)16 p
Gauge Theories from Noncommutative Manifolds
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314388.pdf (Publisher’s version ) (Open Access
Zingeving en het mentaal welzijn van jongeren: De rol van de middelbare school
No full textItem does not contain fulltext14 april 202
Pavlovian impatience: The anticipation of immediate rewards increases approach behaviour
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311792.pdf (Publisher’s version ) (Open Access)People often exhibit intertemporal impatience by choosing immediate small over delayed larger rewards, which has been implicated across maladaptive behaviours and mental health symptoms. In this preregistered study, we tested the role of an intertemporal Pavlovian bias as possible psychological mechanism driving the temptation posed by immediate rewards. Concretely, we hypothesized that the anticipation of immediate rewards (compared with preference-matched delayed rewards) enhances goal-directed approach behaviour but interferes with goal-directed inhibition. Such a mechanism could contribute to the difficulty to inhibit ourselves in the face of immediate rewards (e.g., a drug), at the cost of long-term (e.g., health) goals. A sample of 184 participants completed a newly developed reinforcement learning go/no-go task with four trial types: Go to win immediate reward; Go to win delayed reward; No-go to win immediate reward; and No-go to win delayed reward trials. Go responding was increased in trials in which an immediate reward was available compared with trials in which a preference-matched delayed reward was available. Computational models showed that on average, this behavioural pattern was best captured by a cue-response bias reflecting a stronger elicitation of go responses upon presentation of an immediate (versus delayed) reward cue. The results of this study support the role of an intertemporal Pavlovian bias as a psychological mechanism contributing to impatient intertemporal choice.19 p
Determinants of Self-Management Behavior in Gout: A Scoping Review.
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318082.pdf (Publisher’s version ) (Open Access)OBJECTIVE: This study aimed to identify modifiable determinants of self-management behavior in patients with gout. METHODS: Four databases (Medline, Embase, PsycINFO, and CINAHL) were searched using terms related to gout, self-management, and determinants of behavior as described in the Theoretical Domains Framework (TDF). Two reviewers independently selected relevant studies via screening of title/abstract and full text. Thematic synthesis was performed for qualitative data; quantitative data were summarized using cross-tabulation displaying the investigated associations of determinants with self-management behavior. The TDF facilitated identification and grouping of determinants. RESULTS: From 2,087 unique articles found, 56 studies were included in this review, of which there were 27 qualitative and 29 quantitative studies. Eight themes were identified: knowledge and skills for self-management, acceptance of disease, beliefs about necessity of self-management to improve gout-related health, resistance and reluctance for medication adherence and dietary alteration/changes, negative emotions influencing self-management, social support and interactions, environmental context, and self-regulation of behavior. Quantitative determinants associated with self-management behavior, predominantly medication adherence, were mapped to 12 of the 14 domains of the TDF. No determinants regarding skills and goals have been identified in quantitative research. CONCLUSION: Intervention targets for self-management behavior in patients with gout mainly included determinants related to knowledge, implicit and explicit beliefs and attitudes, the environmental context and resources, and (social) support and reinforcement.01 april 202
Collaborating for gifted students with complex educational needs
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316220.pdf (Publisher’s version ) (Open Access)This grounded theory study investigated collaboration methods among actors working with gifted students with complex educational needs and their parents. Through interviews with students, parents, educational professionals, and care providers, both successful and unsuccessful collaboration strategies were examined. Subsequently, a model was proposed to enhance effective collaboration for this unique, but heterogenous group of students. This model describes overarching collaboration conditions that preferably should be discussed beforehand with actors involved to establish a functional collaborative culture. Furthermore, this model describes specific tasks for all actors involved that could be applied accordingly to enhance collaboration practices. Lastly, a case coordinator should be assigned that ensures continuity, stability, and a constant flow of information. By following this model, educational professionals, care providers, parents, and policy makers may find ways to enhance their collaboration practices to support these students more adequately in their development.13 p
Noot bij: ABRvS 18 juni 2024, 2025, (Peildatum leeftijd bij Chavez-vergunningen)
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318332.pdf (Publisher’s version ) (Open Access)18 juni 202
Understanding overweight and food-related characteristics among Indonesian adolescents from private schools: Who is vulnerable?
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315701.pdf (Publisher’s version ) (Open Access)Radboud University, 24 februari 2025Promotor : Vink, J.M. Co-promotores : Larsen, J.K., Burk, W.J.136 p