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DNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
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326430.pdf (Publisher’s version ) (Open Access)20 p
A "Pandemic-Proof" Methodology for Outbreak Detection Adapted From COVID-19's Impact on Notifications of Infectious Diseases in the Netherlands: Surveillance Study.
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322418.pdf (Publisher’s version ) (Closed access)BACKGROUND: Reporting of notifiable infectious diseases was overall impacted by the COVID-19 pandemic. This could affect disease surveillance and thus, outbreak detection, as it is based on historical data. For effective outbreak detection, it is crucial that communicable disease control professionals can rely on accurate and valuable alarm thresholds to ensure timely and adequate response to potential outbreaks. OBJECTIVE: In this study, we take the first steps in the development of a methodology that adjusts for the impact of the COVID-19 pandemic on the number of notifications of notifiable infectious diseases and provides corrected alarm thresholds for outbreak detection. We identify which infectious diseases were affected by the COVID-19 pandemic, assess the duration of these effects, and explore potential correction methods to improve outbreak detection. METHODS: We analyzed cases of 25 notifiable infectious diseases reported from 2015-2023 in the Netherlands. Negative binomial regression was used to calculate the incidence rate ratios for each period: pre-COVID-19 pandemic, COVID 2020, COVID 2021, COVID 2022, and post-COVID-19 pandemic. To address the decrease in notifications during the COVID-19 pandemic, we tested 3 correction methods: (1) recoding COVID-19 years as missing; (2) imputing with the last pre-COVID-19 pandemic observation; and (3) imputing the historical moving average. RESULTS: Between 2015-2023, a total of 74,990 notifications were reported in the Netherlands, of which 9,836 notifications (13%) occurred during the COVID-19 pandemic. Malaria, typhoid fever, hepatitis A, meningococcal infection, paratyphoid fever, Q-fever, shigellosis, measles, mumps, and pertussis had significantly lower notifications during the COVID-19 pandemic, but the duration and magnitude of the effect differed among the infections. The effect of the COVID-19 pandemic on the notifications of malaria (incidence rate ratio [IRR] 0.17, 95% CI 0.08-0.36) and typhoid fever (IRR 0.12, 95% CI 0.02-0.55) was only seen in 2020, while the notifications for measles (IRR 0.34, 95% CI 0.15-0.75) and pertussis (IRR 0.34, 95% CI 0.20-0.60) were still significantly lower in the post-COVID-19 pandemic period. In addition, the newly calculated alarm thresholds showed a noticeable difference compared with the original unadjusted alarm thresholds. However, the variation among the 3 different corrected alarm thresholds was not substantial. CONCLUSIONS: During the COVID-19 pandemic, notifications of 10 infectious diseases declined significantly. The duration of this decline varied among infections, highlighting the need for pattern-specific adjustments. Our study demonstrates that accounting for the reduced notifications impacts alarm threshold calculations for outbreak detection. We therefore recommend amending the alarm thresholds to account for this impact to ensure reliable outbreak detection, so that communicable disease control professionals can act in a timely and data-driven manner. The next step in the development of the "pandemic-proof" methodology is to determine which correction method is most suitable. Further validation by communicable disease control professionals is essential to assess the applicability of the adjusted alarm thresholds for outbreak detection
Signalement in Jaarboek Parlementaire Geschiedenis 2025. Parlement en politiek in tijden van oorlog
No full textItem does not contain fulltextB. van den Bos Politiek is een vak apart. Ervaren politici vertellen waarom Soesterberg:Aspekt ,2025 978946487278
Estimating mortality from the influenza pandemic of 1918-1919 in Suriname and the Dutch Caribbean
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326421.pdf (Publisher’s version ) (Open Access)10 p
Surgery-induced reduction in inflammation relates to improved neural inhibitory control in obesity
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321859.pdf (Publisher’s version ) (Open Access)Obesity is associated with impaired inhibitory control and low-grade systemic inflammation. Systemic inflammation adversely affects neurocognitive performance. Here, we investigate the effects of metabolic bariatric surgery on systemic inflammation and its influence on neural mechanisms underlying inhibitory control. In a sample of 47 individuals with severe obesity, we assessed inhibitory control processing pre- and 2 years post-bariatric surgery by probing neural activation and connectivity during an fMRI Stroop task. We investigated whether surgery-induced changes in plasma markers of systemic inflammation were related to changes in altered neural responses. Data were collected as part of the BARICO (Bariatric surgery Rijnstate and Radboudumc neuroimaging and Cognition in Obesity) study. Longitudinal analyses revealed decreased Stroop-related activation in the caudate nucleus and the left insula following surgery. These activation changes were accompanied by inflammation-related changes in functional coupling with medial superior frontal regions. Specifically, greater post-surgery decreases in leptin (pro-inflammatory) were associated with decreased connectivity between the anterior insula and the medial superior frontal regions, while increases in macrophage migration inhibitory factor (MIF, potentially neuroprotective) were linked to enhanced connectivity between the caudate nucleus and the medial superior frontal gyrus. Importantly, improved functional coupling between the caudate nucleus and the medial superior frontal gyrus was predictive of better task performance. Our findings suggest that surgery-induced reductions in systemic inflammation may improve inhibitory control in individuals with obesity by promoting neural changes in inflammation-sensitive brain regions and their functional interactions.10 p
Feasibility and clinical potential of exercise interventions during neoadjuvant chemoradiotherapy in patients with esophageal and rectal cancer
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324769.pdf (Publisher’s version ) (Open Access)12 p
Reliability and validity of the diagnostic instrument on adaptive behaviour: A new instrument measuring adaptive behaviour in people with moderate, severe or profound intellectual disability
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325918.pdf (Publisher’s version ) (Open Access)Background: Assessment of adaptive behaviour of people with moderate to profound intellectual disability is hampered by limited variation in scores within this range. We evaluated measurement properties of the Diagnostic Instrument on Adaptive Behaviour (DIAB), which was developed for this population. Method: The DIAB was completed by two care staff members for 73 adults (age 19-84) grouped by level of intellectual disability (i.e., moderate, severe or profound intellectual disability) along with Dutch normed measures of adaptive and motor functioning and a global rating. Results: Inter-rater (ICC = 0.94) and test–retest (ICC = 0.96) reliability met standards. DIAB scores correlated highly with those of the two Dutch instruments (r = 0.90; r = 0.77). Associations between measures were consistent with convergent and discriminant validity. DIAB scores differed between three severity levels of ID (p < 0.001). Conclusion: The DIAB exhibited promising reliability, convergent, discriminant, concurrent, and known group validity.14 p
Cross-border spatial planning in world society: a systems-theoretical perspective
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325170.pdf (Publisher’s version ) (Open Access)Spatial development in cross-border regions, such as along the Dutch-German border, has often been characterized by a lack of coordinated effort and common strategies. Therefore, various authorities, ranging from the European to the local level, have attempted to foster cross-border spatial planning and ‘transcend’ borders, often supported by EU funding schemes, especially in the 1990s, when sentiments expressed the ideal of a ‘borderless Europe’. Nevertheless, reality proved consistently bordered, to a point where the interest in cross-border spatial planning has largely waned. Academic research takes place across various disciplines, most notably in ‘border studies’ and ‘academic spatial planning’. However, a common language has not emerged and our understanding of cross-border spatial planning remains limited. Therefore, this thesis sets out to develop a new theoretical framework which envelops the themes of ‘borders’, ‘regions’ and ‘planning’, based predominantly on systems theory. Analyzing cross-border spatial planning through this lens, by means of second-order observation, we arrive at a paradox, namely that in order to transcend borders, these same borders are needed to arrive at effective spatial planning and thus cannot be glossed out. In this thesis, I develop this ‘systems theory of spatial planning’ whilst at the same showing various implications for practice.Radboud University, 12 november 2025Promotores : Ernste, H., Houtum, H.J. van Co-promotor : Velde, B.M.R. van derxiii, 283 p
Feasibility of Laser Speckle-Based Perfusion Imaging in an Ex-Vivo Liver Model
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324057.pdf (Publisher’s version ) (Open Access)13 p
Labour of Love: Introductory Notes on Religion, Books, and Learning
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324699.pdf (Publisher’s version ) (Open Access