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The future of wastewater treatment plants? Macrophytes have the potential to counteract eutrophication and greenhouse gas emissions by effluent polishing
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314316.pdf (Publisher’s version ) (Open Access)Discharge of treated wastewater, called effluent, can lead to eutrophication and greenhouse gas emissions in receiving waters. Polishing the effluent before it is being discharged, using aquatic plants that take up nutrients and carbon for their growth, could aid in counteracting these effects.Radboud University, 17 januari 2025Promotores : Lamers, L.P.M., Smolders, A.J.P. Co-promotor : Veraart, A.J.252 p
Dust collapse and horizon formation in quadratic gravity
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316531.pdf (Publisher’s version ) (Open Access
Teachers and social cohesion in diverse secondary classrooms
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315486.pdf (Publisher’s version ) (Open Access)The present paper aims to examine how teachers contribute to social cohesion in terms of the three dimensions: social relations, group identification, and the common good. A qualitative study was conducted using interviews with teachers and students and observations in two Dutch secondary schools with diverse student populations. The results showed that the dimension most often addressed was the dimension of social relations, and teachers seemed to focus on individual students more than on the group as a whole. Bridging home and school, and group formation were main themes in the dimension of group identification. The main theme in the dimension of the common good was teacher practices with regard to rules, in which fairness was an important topic for students. The three dimensions of social cohesion are inter-related and should be considered alongside each other when schools are committed to strengthening social cohesion.19 p
Continuous Monitoring Enables Dynamic Biomarkers to Assess Resilience in Acute COVID-19 Patients.
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316628.pdf (Publisher’s version ) (Open Access)Background/Objectives: The effective management of acute illnesses like COVID-19 requires tools to dynamically assess a patient's resilience to health stressors. This study evaluates novel dynamic biomarkers from continuous blood oxygen saturation (SpO(2)) monitoring, exploring their association with patient outcomes to support clinical decision making. Methods: We examined 200 hospital admissions from 181 adults diagnosed with COVID-19. Two dynamic biomarkers reflecting the homeostatic regulation efficiency of SpO(2) were developed to assess their association with adverse hospital outcomes, specifically ICU admission or death, using binary logistic regressions. The resilience exponent α recorded the relative frequency of prolonged SpO(2) declines, while O(2) challenges quantified the dynamic response to changes in O(2) supplementation. Results: Increased resilience exponent α corresponded to decreased odds of adverse outcomes (OR [95% CI] = 0.59 [0.37-0.93], p = 0.03). Larger SpO(2) increases in response to O(2) supplementation were associated with increased odds of adverse outcomes (OR [95% CI] = 1.40 [1.04-1.83], p = 0.03). Additionally, the number of O(2) supplementation increases (OR [95% CI] = 2.91 [1.90-4.49]) and decreases (OR [95% CI] = 0.33 [0.20-0.55]) during hospitalization were independently linked to poorer and improved outcomes, respectively (both p < 0.001). Conclusions: The resilience exponent α and the O(2) challenge response provide insights into the dynamic regulation of SpO(2), reflecting physical resilience in COVID-19 patients. Continuous SpO(2) monitoring in acute care settings could support more informed clinical decisions during patient management
Combining different floating plants for optimal wastewater effluent polishing and carbon-capture
No full textItem does not contain fulltextWe tested four floating plant species and their efficiency in municipal wastewater effluent polishing (nutrient removal and greenhouse gas emission reduction). After that, we combined the most promising nitrogen removing plant species with the most promising phosphorus removal species to assess effluent polishing efficiency. We argue that combining species with different plant-specific traits results in optimal effluent polishing
Optimizing genetic testing in ovarian cancer: The implementation of the Tumor-First workflow
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317683.pdf (Publisher’s version ) (Open Access)Each year, approximately 1300 women in the Netherlands are diagnosed with ovarian cancer. About 100 of these women have a hereditary predisposition. A hereditary predisposition informs ovarian cancer treatment decisions and offers at-risk family members the opportunity to take cancer prevention or early intervention measures, which can be life-saving. “Tumor-First” is a new, efficient, and patient-friendly workflow for genetic testing in ovarian cancer. In this PhD project, the nationwide implementation of the Tumor-First workflow in the Netherlands was stimulated and investigated. The results show that, currently, 85% of the ovarian cancer patients follow the proposed pathway. Compared to other new approaches in healthcare, this is a result to be proud of. This has been achieved thanks to the multidisciplinary collaborative efforts of a large group of healthcare professionals and the support of patient organizations. On an international scale, the Netherlands is unique in this large-scale implementation.Radboud University, 14 april 2025Promotores : Hoogerbrugge-van der Linden, N., Ligtenberg, M.J.L., Hullu, J.A. de214 p
Oral health in systemic sclerosis: A scoping review
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311702.pdf (Publisher’s version ) (Open Access)Background: Limited research on oral health in systematic sclerosis poses a significant challenge for people with systematic sclerosis and health care professionals. We conducted a scoping review to map existing research on oral health–related quality of life in systematic sclerosis across domains including (1) oral manifestations or symptoms, (2) functional consequences, (3) psychosocial aspects, (4) associated patient factors and (5) self-care and management considerations. Methods: We searched MEDLINE, EMBASE, SCOPUS and CINAHL databases to 10 March 2023 for studies on oral health in people with systematic sclerosis. Study data were mapped into pre-specified domains of oral health–related quality of life, subtopics and types of research and reported in tabular form. Results: Of 1460 unique studies reviewed, 91 were eligible and included in the scoping review; of these, 69 (76%) were published as full-text versions, 72 (79%) were from Europe or North America, and 63 (69%) included ⩽50 participants. Only 1 study had >200 participants (N = 382). By domains, 85 (93%) studies reported aspects of oral manifestations or symptoms, with the most common subtopics being oral opening and mandibular function, sicca, periodontitis and soft tissue changes and pathology; 36 (40%) studies provided information on associated patient factors, 23 (25%) on self-care and management, 19 (21%) on psychosocial aspects and 6 (7%) on functional consequences. No studies related to interventions included >50 participants. Conclusion: Most studies on oral health in systematic sclerosis report on manifestations or symptoms, and there are relatively few studies on other important domains. Most studies have been conducted with small samples. Updated systematic reviews should evaluate the quality of existing evidence in domains where enough studies have been done. Large, well-conducted primary studies are needed to address knowledge gaps across domains, including studies that test approaches for supporting oral self-care, improving routine professional care and addressing major disability-causing manifestations.14 p
Hazardous drinking in at-risk young adults: Social context, stress resilience, and emotional wellbeing
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315700.pdf (Publisher’s version ) (Open Access)Radboud University, 18 februari 2025Promotores : Vink, J.M., Cillessen, A.H.N., Luijten, M., Verhagen, M.180 p
Informal care for people with dementia in Europe.
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315927.pdf (Publisher’s version ) (Open Access)INTRODUCTION: Informal care estimates for use in health-economic models are lacking. We aimed to estimate the association between informal care time and dementia symptoms across Europe. METHODS: A secondary analysis was performed on 13,529 observations in 5,369 persons from 9 European pooled cohort or trial studies in community-dwelling persons with dementia. A mixed regression model was fitted to time spent on instrumental or basic activities of daily living using disease severity and demographic characteristics. RESULTS: Daily informal care time was 0.5 hours higher in moderate compared to mild and 1.3h higher in severe compared to mild cognitive impairment. Likewise, this was 1.2h and 2.7h for functional disability and 0.3h and 0.6h for behavioral symptoms in the same directions. DISCUSSION: Estimates can be used in both single- and multi-domain health-economic models for dementia in European settings.01 januari 202
Plan Your Defense: A Comparative Analysis of Leakage Detection Methods on RISC-V Cores
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317380.pdf (Publisher’s version ) (Open Access)SAMOS 202