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Enantioselective Complexation of Protonated Tyrosine by a Chiral Crown-ether: The Nature of the Hydrogen Bonds Makes the Difference
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317167.pdf (Publisher’s version ) (Open Access
Automated Grading of Peripheral Facial Palsy
No full textItem does not contain fulltextThis repository contains the underlying data of the thesis "Automated Grading of Facial Palsy" by T.C. ten Harkel. These data are separated in the following 4 folders: Chapter 2, Chapter 3 (part 1 & 2), Chapter 4, and Chapter 5. Each chapter folder contains a separate Readme.txt file giving a detailed description of the data contained in that folder. A brief overview can be found below:Chapter 2 :This folder contains the RealSense F200 depth accuracy (mm) for each individual patient for each pose of the Sunnybrook Facial Grading System (SFGS).Chapter 3 part 1:This folder contains the following data: (1) the landmarks as placed by the observers for each individual patient during the neutral pose of the SFGS, (2) the depth accuracy of the RealSense D415 for each individual patient during the neutral pose of the SFGS, (3) the landmark placement accuracy between the observers for each individual patient during the neutral pose of the SFGS, (4) the difference between the anthropometric measurements between observers for each individual patient during the neutral pose of the SFGS.Chapter 3 part 2:This folder contains the following data: (1) the landmarks as placed by the observers for each individual patient during the voluntary movements of the SFGS, (2) the depth accuracy of the RealSense D415 for each individual patient during the voluntary movements of the SFGS, (3) the landmark placement accuracy between the observers for each individual patient during the voluntary movements of the SFGS, (4) the difference between the anthropometric measurements between observers for each individual patient during the voluntary movements of the SFGS.Chapter 4:This folder contains the actual SFGS score and predicted SFGS score of the CNN model for all individual patients, divided into the 13 separate SFGS elements and five stratified k-folds.Chapter 5:This folder contains the actual SFGS score and predicted SFGS score of the CNN model for all individual patients, divided into the 13 separate SFGS elements and five stratified k-folds
Impact of Mutation Profile on Outcomes of Neoadjuvant Therapy in GIST.
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317330.pdf (Publisher’s version ) (Open Access)BACKGROUND: Neoadjuvant imatinib therapy plays a crucial role in the management of gastrointestinal stromal tumors (GISTs), but its impact across various mutational profiles remains uncertain. OBJECTIVE: The aim of this study is to describe the clinicopathological features and to assess the response and surgical outcomes of neoadjuvant imatinib in GIST patients exhibiting diverse mutational profiles. METHODS: We conducted a retrospective study, extracting data from the Dutch GIST Registry, including patients treated with neoadjuvant imatinib. Response rate was the primary outcome, and secondary outcomes were the time on neoadjuvant treatment and resection margins (R0 vs. R1/R2), respectively. RESULTS: Between 2009 and 2021, 326 patients were treated with neoadjuvant imatinib, of which 264 (80.9%) underwent resection. A total of 197 (74.6%) of them had a KIT-exon 11 mutation, 19 (7.3%) had other KIT mutations, 10 (3.8%) had PDGFRA D842 mutations, 21 (6.8%) had other PDGFRA mutations, 2 (0.7%) had NTRK mutation, 1 (0.4%) had an SDH mutation, and 17 (6.4%) had WT GISTs. Patients with KIT-exon 11 mutations demonstrated a higher rate of partial response to imatinib (60.5% vs. 33.3%; p = 0.00). A positive resection margin (R1 or R2) was observed in 14 (21.2%) patients with a non-KIT exon 11 mutations and in 11 (5.5%) patients with a KIT-exon 11 mutation (p = 0.00). Moreover, non-KIT exon 11 mutation patients had a shorter median duration of neoadjuvant therapy (5.3 months, range 0.5-21.0) compared to patients with a KIT exon 11 mutation (8.8 months, range 0.2-31.3; p < 0.001). CONCLUSIONS: Our study highlights the variability in treatment response associated with different GIST mutational profiles. Patients with a KIT-exon-11 mutation tended to respond more favorably to neoadjuvant imatinib in terms of partial response and surgical outcomes
A combination of Azolla filiculoides and duckweed for municipal wastewater effluent polishing in a year-round pilot
No full textItem does not contain fulltextTo test the nutrient uptake efficiency and CO2 uptake of two functional groups of floating plants, we grew the water fern Azolla filiculoides and duckweed (a mix of Spirodela polyrhiza, Lemna minor, and L. minuta) on wastewater effluent in a year-round experiment at a wastewater treatment plant. The floating plants were grown in cascading tanks of 300 L, containing either one single plant-type or both plant-types in different sequences. All four treatments were run in duplicate. We assessed nutrient removal efficiency for a full seasonal cycle (October - October) and with two different flow rates: 24 or 12 L h-1. To determine the climate impact of plant-mediated effluent polishing, we measured greenhouse gas fluxes (carbon dioxide, methane and nitrous oxide) on six occasions during the year. Furthermore, we constructed a model to assess the effect of hydraulic residence time and harvesting frequency on phosphorus removal efficiency
Non-classical monocytes are associated with functional markers of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction
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318160.pdf (Publisher’s version ) (Open Access)9 p
Reproducibility of three 6-min walk tests in patients with COPD referred for pulmonary rehabilitation
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314466.pdf (Publisher’s version ) (Closed access
Using SARS-CoV-2 nucleoprotein antibodies to detect (re)infection
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318298.pdf (Publisher’s version ) (Open Access
Revision of Two-temperature Magnetically Arrested Flows onto a Black Hole
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317533.pdf (Publisher’s version ) (Open Access)20 p
Budget Impact Analysis: Digital Workflow Significantly Reduces Costs of Implant Supported Overdentures (IODs).
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316386.pdf (Publisher’s version ) (Open Access)01 februari 202
