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Diseño y despliegue de una estrategia de adopción de servicios en la nube para una entidad pública.
Get PDFEl trabajo parte de la necesidad de modernizar la infraestructura tecnológica de una entidad pública que cuenta con una infraestructura on-premise consolidada pero limitada en escalabilidad, flexibilidad y automatización. Dada la complejidad del entorno local ya existente y los altos requisitos regulatorios, se opta por un enfoque híbrido que preserve el control sobre los datos, mientras se aprovechan las ventajas de la nube pública. El objetivo principal es definir una estrategia de adopción, basada en el marco metodológico Microsoft Cloud Adoption Framework (CAF), abordando aspectos técnicos y organizativos clave como la gobernanza, la seguridad, la conectividad y la automatización. A nivel arquitectónico, se propone un diseño de red tipo and spoke, que facilita la segmentación en diferentes suscripciones y permite filtrar y controlar el tráfico entre servicios. Aunque el enfoque es agnóstico al proveedor y aplicable en cualquier plataforma, la arquitectura base se ha desplegado en Azure a modo de validador, cumpliendo con la gobernanza y permitiendo realizar pruebas de conectividad sobre una zona de aterrizaje aprovisionada mediante herramientas de Infrastructure as Code (IaC) como Terraform. En conclusión, la solución demuestra que una adopción gradual y controlada de la nube es viable incluso en sectores sensibles. Como trabajo futuro, se propone realizar la migración de uno de los servicios no críticos de la entidad y el desarrollo de soluciones nativas en la nube con pipelines CI/CD automatizados.<br /
Estudio de la oxidación del p-cimeno a presión atmosférica.
No full textEn este trabajo se realizó un estudio de la oxidación de p-cimeno a presión atmosférica usando dos reactores de cuarzo. Para ello, se modificó la estequiometría de la reacción, pasando de condiciones reductoras a oxidantes, así como la concentración inicial de p-cimeno, desde 100 ppm hasta 400 ppm. También se llevó a cabo un experimento con agua para evaluar el posible efecto catalítico causado por las paredes del reactor. Los experimentos se realizaron en el intervalo de temperaturas de 400°C hasta 1150°C. Se evaluó el consumo de los reactivos, así como la formación de los principales productos de la oxidación, tales como el CO y el CO₂, y productos secundarios, como el C₂H₂, C₂H₄, benceno y tolueno. Posteriormente, se realizaron simulaciones para comparar con los datos experimentales usando el programa CHEMKIN en conjunto con un modelo cinético de la literatura. A partir de los resultados obtenidos, se observó que la configuración del reactor utilizado fue un factor importante para realizar correctamente la oxidación del p-cimeno. Se observó también que, al aumentar la temperatura, el p-cimeno se oxidaba. Además, al aumentar el coeficiente estequiométrico de la reacción o la concentración inicial de p-cimeno, la temperatura a la que los productos intermedios y el monóxido de carbono se oxidaron para formar CO₂ disminuyó. Adicionalmente, se identificó que las paredes de cuarzo del reactor no tuvieron efecto catalítico sobre la reacción de oxidación del p-cimeno.<br /
Métricas en transición : evaluación de indicadores tradicionales y alternativos en revistas latinoamericanas de ciencias sociales
Get PDFLas altmetrics están transformando la evaluación del impacto científico, complementando los indicadores bibliométricos tradicionales con una visión más amplia y dinámica de la influencia de la investigación en la era digital, es decir, el ecosistema científico atraviesa un cambio en su modelo tal cual se ha conocido en los últimos años. El objetivo principal de este estudio es analizar la distribución de las revistas de ciencias sociales de América Latina, indexadas en el Scimago Journal Rank (SJR) 2023, y la evolución de sus métricas tradicionales y alternativas en el período 2017 – 2023, para identificar dinámicas de crecimiento y diferencias significativas relacionadas con la evaluación de impacto de las publicaciones científicas. El análisis consideró las puntuaciones anuales de 12 métricas alternativas y 9 métricas tradicionales de 356 revistas, así como, los datos obtenidos a partir de la aplicación de una encuesta a los editores de las revistas estudiadas. Los resultados revelan una representación regional limitada para las ciencias sociales dentro del SJR y un patrón desigual en la producción editorial regional liderada por Brasil seguido de Chile, Colombia y México. En métricas tradicionales se identificó un crecimiento sostenido de las puntuaciones SJR, CiteScore y JCI, con una integración más lenta en métricas del Journal Citation Reports (JCR), acompañado por un uso editorial consolidado en la evaluación de impacto. Las métricas alternativas presentaron valores bajos y dispersos. Las menciones en X (Twitter), Wikipedia, medios de comunicación y blogs mostraron un crecimiento estadísticamente significativo, mientras que lectores en Mendeley, menciones en Facebook y citas en Dimensions reflejaron un descenso. Este comportamiento asimétrico sugiere una transición en curso en los modos de difusión científica, aunque prevalece el modelo tradicional basado en citas
Glutathione Threshold‐Triggered Selective Breakability of Organosilica Nanocapsules
Get PDFBiomolecules like proteins and enzymes can target and disrupt cancer cell pathways more specifically and with lower toxicity than traditional treatments. However, their lack of stability and methods for their effective delivery still present unsolved challenges. Silica nanocapsules have been proposed as carriers capable of protecting sensitive loads but their use is limited by their low biodegradability. For this reason, breakable silica structures, able to disassemble when exposed to representative levels of biomolecules readily available in the tumor microenvironment (TME), appear as ideal delivery vectors. In this work, we focus on the optimization of the synthesis parameters governing the breakability of organo‐silica nanocapsules containing cleavable disulfide bonds. The objective is to trigger selective release in the presence of glutathione (GSH), a key molecule overexpressed in tumor cells. However, disulfide bonds can also be degraded in the presence of other molecules, which reduces the selectivity of delivery. We have modified the synthesis to obtain a response that leads to silica disassembly only when GSH levels are above a certain threshold, while remaining stable against other reductants, such as those present in standard extracellular culture media. The selection of the proper silica precursor was critical to obtain silica capsules that is able to disassemble and release Cytochrome C (CytC) upon exposure to GSH concentrations typical of those existing in the TME
Acceptance of digital health in Portugal: an example of digital divide
No full textDigital health technologies are becoming increasingly important in achieving broader healthcare goals worldwide, with significant investments in infrastructure and legislative frameworks to regulate this growing sector. However, despite substantial structural support, there remains a gap between investment and consumer usage, particularly evident in Portugal. This study aims to understand attitudes and behaviors towards digital health among the Portuguese population and identify key variables influencing their adoption. Utilizing the Technology Acceptance Model, socio-demographic and subjective factors were examined in a national online survey, part of the CROss-National Online Survey 2 panel associated with the European Social Survey Round 10.The results indicate a positive perception of digital health technologies, with high scores for perceived ease of use (M = 4.97, SD = 1.18) and for the value attributed to these tools (M = 4.71, SD = 1.14). However, their actual use remains relatively low (M = 1.23, SD = 0.94), with concerns about the quality of care and dependence on technology (M = 4.01, SD = 0.94). Older people perceived less ease of use of digital health tools (r = -.234, p < .01), along with less favorable attitudes (r = -.195, p < .01) and lower intention to use them (r = -.145, p < .01). In contrast, literacy, income and education level were positively associated with the above dimensions, highlighting the digital health divide. While digital health technologies offer promising opportunities, it is essential to address their potential to exacerbate health inequalities. This study underscores the significance of understanding socio-demographic and subjective factors in shaping attitudes and behaviors towards digital health. The implications of the findings for policy and intervention aiming to enhance digital healthcare engagement and accessibility are discussed, including the implementation of targeted national digital health literacy programs and the integration of digital health education into formal education curricula.
Keywords: digital health attitudes and behaviors; social determinants of health; Technology acceptance model; Portuga
Video Game Abuse and Cyberbullying Among Spanish Adolescents: An Age and Sex Comparison
No full textThe abuse of video games and cyberbullying have lately been occurring at younger ages, but there are few studies of a developmental nature and that consider all types of video games. The aim of this study is to analyze whether video game abuse predicts cyberbullying considering sex and age in a sample of n = 619 Spanish students (52.7% girls, 47.3% boys) aged 10 and 18 years (M: 12.9 years (SD = 2.3). Applying a multigroup analysis, video game abuse predicts participation in cyberbullying in both sexes, and in cybervictimization to a greater extent in boys. On the other hand, our results reveal that this prediction is significantly higher in the youngest group (10–12 years), which represents novel advances in the prevention of these risks
The No Limits project: a pilot experience for promoting sports activities among gifted youth
No full textThe ‘No Limits Sport for Gifted Children’ project (Erasmus+ Sport) was designed to investigate and promote sports participation among gifted and talented (GT) youth, addressing their specific barriers and needs. Through a strategic collaboration between institutions from Spain and Latvia, the project was structured into four phases: preparation, implementation, evaluation, and dissemination, including activities such as training workshops for coaches, needs analysis, and a pilot experience with GT children.
The results showed that 84% of GT youth participated in sports over the past year, with basketball, athletics, and football being the most popular sports. Their main motivations were fun (34,6%) and enjoyment of sports (19,6%). However, GT youth exhibited lower general interest in sports (48% reported little or no interest) and higher inactivity rates (16%) compared to the general population. Furthermore, coaches demonstrated limited knowledge of this group's needs, with 51,5% reporting familiarity but lacking specific training.
The pilot experience involved 70 young participants in activities such as orienteering and parkour, achieving high levels of satisfaction. Additionally, workshops trained 142 coaches and educators, who positively assessed the usefulness and applicability of the training.
The project highlights the importance of inclusive strategies combining awareness, specialized training, and adapted sports environments to maximize the physical, cognitive, and emotional benefits of sports for GT youth. This underscores the role of sports as a cornerstone for their holistic development
Ultra-Processed Foods Consumption and Metabolic Syndrome in European Children, Adolescents, and Adults: Results from the I.Family Study
No full textBackground/Objectives: Ultra-processed foods (UPFs) constitute a large proportion of the daily energy intake of Europeans, particularly among children and adolescents. High UPFs consumption is associated with poor dietary quality and adverse health outcomes. This study aimed to examine whether high UPFs consumption is associated with metabolic health in children, adolescents, and adults, using data from the I.Family study. Methods: This cross-sectional analysis (2013/2014) included 2285 participants: 147 children (6–9 years), 645 adolescents (10–19 years), and 1493 adults (≥20 years). For the children and adolescents, a metabolic syndrome (MetS) z-score was calculated, consisting of age- and sex-standardized z-scores of WC, HOMA index, HDL-C, TRG, systolic blood pressure (SBP), and diastolic blood pressure (DBP). For the adults, MetS was defined according to the criteria of the International Diabetes Federation Task Force and other societies. The participants completed at least one 24 h recall, from which their UPFs consumption was estimated using the NOVA classification. The consumption levels were divided into age- and sex-specific quintiles based on the relative energy contribution of these foods. Multivariable regression analyses were conducted to evaluate the associations between UPFs consumption and MetS or its components. Results: No statistically significant associations were found between UPFs consumption and MetS or its components in any age group. The effect sizes were negligible across the quintiles (η2 = 0.0065 in children, 0.015 in adolescents, and 0.0009 in adults). While the mean MetS score showed little variation, the prevalence of MetS scores above the 90th percentile increased in the highest UPFs quintile among the children. The diet quality decreased with increasing UPFs consumption. Conclusions: UPFs consumption was not associated with MetS or its components across the age groups. However, a decline in diet quality was observed with increasing UPFs intake, highlighting the importance of public health strategies to reduce UPFs consumption and improve dietary patterns, particularly among younger populations
Editorial: The special issue of ENERGY - The International Journal dedicated to the 7th International Conference on Polygeneration (ICP-2023)
No full textRegulatory networks of FUR and NtcA are intertwined by transcriptional regulators, two-component systems, serine/threonine kinases, and sigma factors in Anabaena sp. PCC 7120
No full textFUR proteins in Anabaena sp. PCC 7120 (FurA/Fur, FurB/Zur, and FurC/PerR) are a family of transcriptional regulators involved in the control of highly important metabolic processes such as the maintenance of metal homeostasis, the regulation of oxidative stress response, and the adaptation to nitrogen starvation. Previous RNAseq analyses of FUR misregulation strains revealed a broad panel of genes directly modulated by these transcriptional regulators. However, the expression of several regulatory proteins was also altered, indicating that FUR proteins could extend their influence by exerting a second level of regulation through some members of their regulons. In this work, by combining differential gene expression data and electrophoretic mobility shift assays (EMSAs), we sought to identify novel direct targets of FUR proteins with regulatory functions, namely, transcriptional regulators, two-component systems, sigma factors, and other proteins with regulatory functions such as serine/threonine kinases. This allowed us to build a network composed of these regulatory proteins that are directly modulated by FUR proteins. In addition, taking into account the role of FUR proteins in the regulation of nitrogen metabolism, the overlap between FUR and NtcA regulatory networks was studied, revealing that an important part of the FUR network is coregulated by NtcA. These results unveil a complex network in Anabaena in which regulatory proteins hierarchically below FUR or NtcA proteins could be controlling the expression of several genes, connecting the integration of stress signaling performed by FUR and NtcA to a wide set of cyanobacterial transcriptional responses