Leiden University Scholary Publications
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An organizational-level workplace intervention to improve medical doctors’ sustainable employability: study protocol for a participatory action research study
Full text linkHealth and Well-bein
Tellen én meetellen: samen recht doen aan kinderen en gezinnen in de jeugdbescherming
Full text linkOratie uitgesproken door Prof.dr. Anouk Goemans bij de aanvaarding van het ambt van bijzonder hoogleraar Jeugdhulp en jeugdbescherming vanuit pedagogisch en juridisch perspectief aan de Universiteit Leiden op vrijdag 16 januari 2026FdR – Publicaties niet-programma gebondenEducation and Child Studie
Brand new translation, same old story?: The perpetuation of female and racial stereotypes in (re)translation
Full text linkThis thesis explores the potential effects of translation choices on the way women and Black people are portrayed in works of fiction and non-fiction. It does so by examining the Dutch translations and retranslations of The Great Gatsby by F. Scott Fitzgerald and The Fire Next Time by James Baldwin, focusing on the characterization of the female protagonist and on the portrayal of Black Americans respectively. By cataloguing the differences between the American originals and their Dutch translations, the analyses draw attention to the influence that translators may – either consciously or unwittingly – have on female and racial stereotyping. The emerging patterns found in the reader response survey conducted for the two Dutch translations of The Great Gatsby confirm that translator decisions may indeed affect the way readers receive and perceive female characters. The conclusion of the second close-reading study of The Fire Next Time is that the combination of implicit bias on the part of the translator and his translation strategies aimed at making the text understandable to contemporary readers have had an undesirable effect. Modern and Contemporary Studie
Lost in translation: how public managers across hierarchical levels shape customization depending on their managerial or professional identity
Full text linkUsing identity theory, we analyse how frontline, middle and top managersshape customization, dependent on their differences in professional and man-agerial identities. Our qualitative research shows that frontline managers prior-itize professional values in managing customization, but these often conflictwith managerial values. Top managers acknowledge the importance of custo-mization and seek to balance both identities, but face challenges to maintainthis focus as it moves down the hierarchy. Middle managers translate strategicgoals into practice, yet their focus on managerial values cause customization tofade. This study highlights customization getting lost in translation when itcascades down the hierarchy.The politics and administration of institutional chang
Framing conditionality in times of crisis: EU institutional responses to Turkey’s democratic decline (2014–2024)
No full textSecurity and Global Affair
Towards a characterization of human spatial exploration behavior
No full textSocial, Cognitive, and Affective Decision Makin
The invasive marsh frogs advancing into The Netherlands carry a diverse mix of mtDNA
Full text linkAnimal sciencesNaturali
Navigating solute carrier transporters: a comprehensive review of functionalized small molecule probes for target identification and characterization
Full text linkSolute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport, SLCs have emerged as crucial players in health and disease. Dysregulation of SLC function has been implicated in a spectrum of disorders, including metabolic diseases, cancer, and neurological afflictions. Despite their significance, SLCs remain relatively understudied compared to other protein classes, resulting in a gap in understanding their molecular mechanisms of action and potential as therapeutic targets. This review aims to address this gap by providing a comprehensive overview of the diverse array of small-molecule probes utilized in the study of SLCs. Various types of functionalized probes, amongst which fluorescent probes, bivalent probes, covalent inhibitors, affinity-based probes, photoswitchable inhibitors and proteolysis targeting chimeras (PROTACs), have been designed to investigate transporter function, substrate specificity, and regulatory mechanisms. In this review, we describe the principles underlying the design and synthesis of these probes, highlights key examples of their application in elucidating transporter function and regulation, and discuss insights gained from such studies. Furthermore, we examine current challenges and future directions in the development and utilization of small-molecule probes for SLC transporter research. By shedding light on the intricate mechanisms involved in transporter function and regulation, this review not only enhances the understanding of SLCs but also highlights their potential as therapeutic targets in drug discovery and thereby may facilitate systematic implementation of these innovative research approaches and the refinement of existing methodologies.Medicinal Chemistr
Lipid nanoparticle technology for mRNA delivery: bridging vaccine applications with fundamental insights into nano-bio interactions
Full text linkLipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding. This thesis aimed to advance the rational design of mRNA–LNP systems by systematically examining how lipid composition governs delivery performance, immune activation, and nano–bio interactions across in vitro and in vivo models. Comparative analysis of ionizable lipids showed that while LNPs shared similar physicochemical properties and mRNA encapsulation efficiency, their biological activity was highly context dependent, with in vitro potency poorly predicting in vivo protein expression and immune responses. To overcome the weak immunogenicity of tumor antigens, a heterologous prime–boost vaccination strategy combining antigen-encoding mRNA-LNPs with costimulatory agonist-based boosters was developed, significantly enhancing the magnitude and durability of antigen-specific T cell responses and revealing lipid-dependent, tissue-specific immune effects. Further investigation into nano–bio interactions highlighted the role of helper lipid charge in macrophage targeting, demonstrating that cationic helper lipids improve endosomal escape and mRNA delivery but raise safety considerations. Finally, chemically modified, clickable ionizable lipids combined with advanced imaging approaches enabled super-resolution visualization of LNP intracellular trafficking and disassembly, providing powerful tools to elucidate mechanisms underlying mRNA-LNP delivery.SECIHTI-Mexico [CVU/grant number: 619711/766609]Supramolecular & Biomaterials Chemistr
Employing and developing operando scanning tunneling microscopy for Fischer-Tropsch synthesis
Full text linkThis thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels. The central aim is to understand how cobalt catalyst surfaces evolve and function under realistic reaction conditions.Chapter 3 examines cobalt surfaces at room and elevated temperatures. At low temperatures, carbon monoxide adsorbs molecularly and slightly roughens the surface. At high temperatures, carbon reorganizes into a graphite-like layer that alters surface structure and reactivity. Under reaction conditions, the system exhibits striking oscillatory behavior: gas concentrations and product formation pulse rhythmically. These oscillations occur only when both hydrogen and carbon monoxide are present, suggesting that transient carbon clusters periodically block and unblock active sites, dynamically reshaping the surface.Chapter 4 explores oxidized cobalt surfaces, showing that oxidation strongly suppresses activity at room temperature. Although carbon monoxide can partially reduce the surface at higher temperatures, full catalytic performance is not recovered, highlighting the lasting impact of oxygen contamination.Chapter 5 demonstrates that rhenium promotion improves cobalt reducibility and stability, particularly in the presence of water, which otherwise raises activation temperatures. Chapter 6 presents the design of a high-pressure, high-temperature STM capable of operando studies, integrating advanced heating concepts and fluid-flow considerations. Overall, the thesis reveals catalytic surfaces as dynamic systems shaped by chemistry, temperature, and reactor physics.NWOCatalysis and Surface Chemistr