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Substituted thiazoles VI. Synthesis and antitumor activity of new 2-acetamido- and 2 or 3-propanamido- thiazole analogs
No full textA novel series of 2-acetamido and 2 or 3-propanamido derivatives of 4- or 5- substituted-thiazoles was designed and synthesized. Structure elucidation of the new synthesized compounds was attained by the use of C NMR, and Mass spectrometry. Compounds were subjected to NCI in vitro assessment for their antitumor activity, at a single dose of 10 μM of test compounds. Compounds bearing straight chain substituent or 4-phenyl function proved to be more active than their branched or 4-methyl congeners. Compounds 37, 41 and 42 exhibited broad spectrum antitumor activity. Compounds 23 and 27 proved lethal while compounds 18, 21, 32 and 37 showed remarkable GI values of 75.5, 69.3, 96.2 and 92.7% to the Leukemia CCRF-CEM cell line, respectively
Characterization of Fennel Fruits: Types and Quality (1)
No full textAbstract:
Four samples of different fennel fruit cultivars (F 1-F 4), obtained from El-Fayoum, Egypt (F 1), El- Menia, Egypt (F 2), Sudan, El-Khartoum (F 3), and Germany (F 4) were cultivated in MEPACO`s Farm (Arab Co. for Pharm. and Med. Plants, Cairo, Egypt) and the obtained fruits were subjected to macro- and micromorphological stereomicroscopic examination as well as GC-MS analysis of their volatile oils.
The aim of the study is to determine the differences in the macro- and micro- characters of different fruit cultivars as well as their oil constitutes.
The results show different exomorphic parameters viz. shape, color, dimensions and surface sculpture. Also the tereomicroscopic examination showed differences in the epicarp, mesocarp; vitti and endosperm. GC-MS analysis of volatile oils of (F 1-F 4) showed on comparing three parameters; fenchone, estragole and trans-anethole that F 4 has the highest percentage of trans-anethole (78.98%), while F 1 and F 2 have close values (1.05 and 1.02%, respectively) followed by F 3 (3.02%). F 4 has the lowest percentage of estragole (3.97%); while (F 1-F 3) have higher values (78.58, 64.81 and 25.79%, respectively). Also F 4 has doubled the percentage of fenchone (6.73%) of F 1 and F 2 (2.54 and 2.57%, respectively), while F 3 has 0.69%. Thus results show that the two cultivars growing in Egypt (F 1 and F 2) have almost the same ratios of the compared parameters while, the Sudan cultivar F 3 is closer to F 1 and F 2 than it is to F 4. Also the three cultivars (F 1-F 3) are far from specification of sweet fennel oil but close to bitter fennel oil. The German cultivar (F 4) has the best oil quality as a sweet fennel. Investigation of
the powdered samples (F 1-F 4) showed that only F 4 is different in having higher abundant fragments of reticulate
parenchyma cells with ratio of 1:3 {F 4:(F 1-F 3)}. In conclusion: These findings are of pharmaceutical-industrial
value helping in the production of herbal pharmaceutical products of fennel fruit and/or oil of known higher quality
Fundamentals of digital and computer design with VHDL / Richard S. Sandige, Michael L. Sandige.
No full textIncludes index.Book fair 2013.xx, 716 p.
Computers and society : computing for good / Lisa C. Kaczmarczyk.
No full textIncludes bibliographical references and index.Book fair 2013.xxi, 283 p.
Introduction to computer graphics : using Java 2d and 3d / Frank Klawonn.
No full textIncludes bibliographic references and index.Book fair 2013.253 p.
Genetic, molecular, and biochemical basis of fungal tropolone biosynthesis
No full textWe thank the Engineering and Physical Sciences
Research Council for Grant EP/F066104/1 (J.D. studentship, Z.S. funding,
LCMS equipment); Al Baha University, Saudi Arabia (A.a.F. studentship);
the Egyptian Cultural Centre London (S.Y.Y. visiting fellowship); China Scholarship
Council (M.C., visiting studentship); and Dr. Mairi Haddow for assistance
with X-ray crystallography
The historic urban landscape : managing heritage in an urban century / by Francesco Bandarin and Ron Van Oers.
No full textIncludes bibliographical references (p. [217]-228) and index.Book fair 2013.xxv, 236 p.
MC3T3 preosteoblast differentiation on bone morphogenetic protein-2 peptide ormosils
No full textThe design of biointerfaces that stimulate cell differentiation is a rapidly growing area of research that has significant implications in biomedicine. Biointerfaces that stimulate osteogenesis are typically composed, at least in part, of a biomimetic ceramic material, such as bioactive glass. Cell differentiation on these materials is quite remarkable, and can be enhanced by further addition of extracellular signals, such as growth factors or extracellular matrix proteins. However, addition of whole proteins can be difficult to replicate due to protein conformational changes on surfaces of interest. To investigate whether well-controlled synthetic peptide combinations can stimulate osteogenesis of MC3T3 pre- osteoblast cells, we decorated the surface of 2D silica thin films made by the sol–gel technique with 3 peptide sequences from different proteins known for their capabilities to stimulate the osteogenesis process (fibronectin, BMP-2, and BMP-9). MC3T3 pre-osteoblasts were seeded onto the materials in a standard proliferation medium and grown for five weeks. Cells were also grown on tissue culture treated cover slips with and without differentiation induction media as positive and negative controls, respectively. Cells were examined weekly to assess osteogenesis. MC3T3 pre-osteoblasts appear to undergo enhanced differentiation on the peptide-silane samples over silica thin films, and the differentiation capacity of the cells exposed only to peptide-silane surfaces approaches that of cells grown in chemical differentiation induction media
Marketing communications : integrating offline and online with social media / PR Smith & Ze Zook.
No full textIncludes index.business bookfair2016xviii, 483 p.
Craig's restorative dental materials. 13th ed.
No full textOrder of editors reversed on prev. ed.Includes bibliographical references and index.xvi, 400 p.