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Cellular uptake, cytotoxicity and in-vivo evaluation of Tamoxifen citrate loaded niosomes
No full textOne of the main challenges in Tamoxifen cancer therapy is achieving localized,
efficient and sustained delivery without harming normal healthy organs. This study focused on evaluating Tamoxifen Citrate (TMC) niosomes for localized cancer therapy through in-vitro breast cancer cytotoxicity as well as in-vivo solid anti-tumor efficacy. Different niosomal formulae were prepared by film hydration technique and characterized for entrapment efficiency % (E. E), vesicle size, morphology, and in- vitro release. The cellular uptake and anti-cancer activity were also tested in-vitro using MCF-7 breast cancer cell line. Moreover, in-vivo anti-tumor efficacy was examined in Ehrlich carcinoma mice model through reporting solid tumor volume regression and tissue TMC distribution. The obtained niosomes prepared with Span 60: cholesterol (1: 1 molar ratio) showed a distinct nano-spherical shape with EE up to 92.3% ± 2.3. Remarkably prolonged release of TMC following diffusion release behavior was detected. The optimized formula showed significantly enhanced cellular uptake (2.8 fold) and exhibited significantly greater cytotoxic activity with MCF-7 breast cancer cell line. In-vivo experiment showed enhanced tumor volume reduction of niosomal TMC when compared to free TMC. Based on these results, the prepared niosomes demonstrated to be promising as a nano-size delivery vehicle for localized and sustained TMC cancer therapy
Chemical Composition and Biological Activity of the Essential Oils Obtained From Yellow and Red Carrot Fruits Cultivated In Egypt
No full textThe chemical composition of the essential oils from the fruits of Daucus carota var. sativus (yellow carrot) and var. boissieri (red carrot) was determined using GC/FID and GC/MS. Altogether; 29 and 32 compounds were identified accounting for 96.58 and 96.72 % of the total detected components in the hydrodistilled yellow and red carrot oils, respectively. Carotol constituted the major component in both oils (~66‒68 %). The antioxidant activity was assessed using both diphenylpicrylhydrazyl (DPPH•) and 2- deoxyribose degradation (2-DR) assays. Both oils reduced DPPH• and inhibit 2-DR with IC50 values of 12.71, 14.15, mg/ml and 87.15, 88.75 µg/ml for the yellow and red carrot oils, respectively. Inhibition of both 5- lipoxygenase (5-LOX) enzyme and prostaglandin E2 (PGE2) production were used to assess the anti- inflammatory activity. Yellow carrot oil showed better activity towards inhibition of 5-LOX (IC50 of 37.53 µg/ml). The cytotoxicity of both oils was determined against both MCF-7and HepG-2 cancer cell lines using the sulforhodamine B (SRB) assay. The highest cytotoxic activity was observed against HepG-2 cell with IC50 values ranging from 163-172 μg/ml for both oils. These results indicate promising antioxidant and anti-inflammatory activity of both oils and provide a rationale for their uses in many skin diseases
Ibrahim M. Mahdi1, KHaled M. Heiza2 and Nagwan E. Abo Elenen3
No full textValue Engineering (VE) concept does not mean a cost reduction only, but it extends beyond. VE is a powerful problem-solving tool that can reduce costs while maintaining or improving performance and quality requirements. It's a function- oriented, systematic team approach to providing value in a product or service. Construction project as a product or service is generally considered to have good value if this product or service has appropriate performance and cost. The construction product's characteristics differ than those in manufacture in many aspects such as immobility, complexity, durability, cost lines, and high degree of social responsibility. These characteristics are highly affected by the construction technology. Where, adopting these new technologies and working method in proper work environment can maximize the product with a working time reduction by 25% and cost reduction by 20% in average. Slip Form (S.F) is considered one of these common methods of construction. An assessment of the S.F includes productivity, appropriate speed in addition to auxiliary resource combinations. This research aims at create awareness of VE, and demonstrated the benefits gained when it applied to construction projects
Smart grid standards : specifications, requirements, and technologies / Takuro Sato, Daniel M. Kammen, Bin Duan, Martin Macuha, Zhenyu Zhou, Jun Wu, Muhammad Tariq, Solomon Abebe Asfaw.
No full textIncludes bibliographical references and index.xviii,463 pages :A fully comprehensive introduction to smart grid standardsand their applications for developers, consumers and serviceproviders
The critical role of standards for smart grid has already beenrealized by world-wide governments and industrial organizations.There are hundreds of standards for Smart Grid which have beendeveloped in parallel by different organizations. It istherefore necessary to arrange those standards in such a way thatit is easier for readers to easily understand and select aparticular standard according to their requirements without goinginto the depth of each standard, which often spans from hundreds tothousands of pages.
The book will allow people in the smart grid areas and in therelated industries to easily understand the fundamental standardsof smart grid, and quickly find the building-block standards theyneed from hundreds of standards for implementing a smart gridsystem. The authors highlight the most advanced works and effortsnow under way to realize an integrated and interoperable smartgrid, such as the “NIST Framework and Roadmap for Smart GridInteroperability Standards Release 2.0†, the†IEC SmartGrid Standardization Roadmap†, the ISO/IEC’s“Smart Grid Standards for Residential Customers†, theZigBee/HomePlug’s “Smart Energy Profile Specification2.0†, IEEE’s P2030 “Draft Guide for Smart GridInteroperability of Energy Technology and Information TechnologyOperation with the Electric Power System (EPS), and End-UseApplications and Loads†, and the latest joint researchproject results between the world’s two largest economies, USand China. The book enables readers to fully understand the latestachievements and ongoing technical works of smart grid standards,and assist industry utilities, vendors, academia, regulators, andother smart grid stakeholders in future decision making.
The book begins with an overview of the smart grid, andintroduces the opportunities in both developed and developingcountries. It then examines the standards for power griddomain of the smart grid, including standards for blackoutprevention and energy management, smart transmission, advanceddistribution management and automation, smart substationautomation, and condition monitoring. Communication and securitystandards as a whole are the backbone of smart grid and theirstandards, including those for wired and wireless communications,are then assessed. Finally the authors consider the standards andon-going work and efforts for interoperability and integrationbetween different standards and networks, including the latestjoint research effort between the world’s two largesteconomies, US and China.
A fully comprehensive introduction to smart grid standards andtheir applications for developers, consumers and serviceproviders
Covers all up-to-date standards of smart grid, including thekey standards from NIST, IEC, ISO ZigBee, IEEE, HomePlug, SAE, andother international and regional standardization organizations. TheAppendix summarizes all of the standards mentioned in the book
Presents standards for renewable energy and smart generation,covering wind energy, solar voltaic, fuel cells, pumped storage,distributed generation, and nuclear generation standards. Standardsfor other alternative sources of energy such as geothermal energy,and bioenergy are briefly introduced
Introduces the standards for smart storage and plug-in electricvehicles, including standards for distributed energy resources(DER), electric storage, and E-mobility/plug-in vehicles
The book is written in an accessible style, ideal as anintroduction to the topic, yet contains sufficient detail andresearch to appeal to the more advanced and specialist reader
EVALUATION OF NANOLEAKAGE OF TWO DUAL CURE SELF-ADHESIVE RESIN CEMENTS
No full textAim of the study: This in vitro study was conducted to evaluate nanoleakage of two contemporary dual cured self-adhesive resin cements bonding high strength ceramic to dentin. Materials and Methods: sixteen rectangular-shaped zirconia blocks (ICE Zirkon Translucent ZirkonZhan, Italy) were fabricated and divide into two group according to cements used for cementation of zirconia blocks to freshly prepared flat dentin surfaces to form assemblies. (Group1- RelyXU200 (RXU200), (3M ESPE Germany) and group2- Multilink® Speed (MS), (Ivoclar Vivadent, Liechtenstein)). Each group were divided to three subgroups ten assemblies in each according to storage periods 1day, 7 days without thermocycling and 7 days with thermocycling for 500 cycles at temperature between 5 and 55 period the assemblies were sectioned into1 mm thick slaps. Two slaps from each assembly were selected, stained with 50wt% ammoniacal silver nitrate and tested for nanoleakage using Electron Dispersive Analytical X-ray (EDAX). Results: Group 2 showed the higher insignificant mean of nanoleakage (15.55±4.47 AgL in wt%) than group 1 (13.83±5.36 AgL in wt%). One day follow-up period showed the highest significant mean of nanoleakage (18.35±4.18 AgL in wt%) followed by seven days without thermocycling (13.10±4.44 AgL in wt%) and 7 days with thermocycling (11.87±4.13 AgL in wt%). Conclusions: RXU200 cement had lower mean of nanoleakage than MS and Storage time had influences on nanoleackage but thermocycling had not
Managing online risk : apps, mobile, and social media security / Deborah Gonzalez.
No full textcomputer bookfair2016xiii, 271 pages :"In recent years, building a corporate online presence has become nonnegotiable for businesses, as consumers expect to connect with them in as many ways as possible. There are benefits to companies that use online technology, but there are risks as well. Managing Online Risk presents the tools and resources needed to better understand the security and reputational risks of online and digital activity, and how to mitigate those risks to minimize potential losses. Managing Online Risk highlights security and risk management best practices that address concerns such as data collection and storage, liability, recruitment, employee communications, compliance violations, security of devices (in contexts like mobile, apps, and cloud computing), and more. Additionally, this book offers a companion website that was developed in parallel with the book and includes the latest updates and resources for topics covered in the book"-- Provided by publisher
Refactoring for software design smells : managing technical debt / Girish Suryanarayana, Ganesh Samarthyam, Tushar Sharma.
No full textcomputer bookfair2016Includes bibliographical references (pages 227-230) and index.xix, 237 pages
Analytical mechanics : solutions to problems in classical physics / Ioan Merches, Daniel Radu.
No full text"CISP."engineering bookfair2016Includes bibliographical references (pages 439-442).442 pages
Pharmaceutical amorphous solid dispersions / edited by Ann Newman, Seventh Street Development Group, Lafayette, Indiana, USA.
No full textIncludes bibliographical references and index.pharmacy bookfair2016xiii, 488 pages
Information systems reengineering, integration and normalization / Joseph Shi Piu Fong.
No full textcomputer bookfair2016Includes bibliographical references and index.xvii, 391 pages