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Simultaneous determination of mebeverine hydrochloride and chlordiazepoxide in their binary mixture using novel univariate spectrophotometric methods via different manipulation pathways
No full textSmart, sensitive, simple and accurate spectrophotometric methods were developed and validated for the quantitative determination of a binary mixture of mebeverine hydrochloride (MVH) and chlordiazepoxide (CDZ) without prior separation steps via different manipulating pathways. These pathways were applied either on zero order absorption spectra namely, absorbance subtraction (AS) or based on the recovered zero order absorption spectra via a decoding technique namely, derivative transformation (DT) or via ratio spectra namely, ratio subtraction (RS) coupled with extended ratio subtraction (EXRS), spectrum subtraction (SS), constant multiplication (CM) and constant value (CV) methods. The manipulation steps applied on the ratio spectra are namely, ratio difference (RD) and amplitude modulation (AM) methods or applying a derivative to these ratio spectra namely, derivative ratio (DD1) or second derivative (D2). Finally, the pathway based on the ratio spectra of derivative spectra is namely, derivative subtraction (DS). The specificity of the developed methods was investigated by analyzing the laboratory mixtures and was successfully applied for their combined dosage form. The proposed methods were validated according to ICH guidelines. These methods exhibited linearity in the range of 2–28 μg/mL for mebeverine hydrochloride and 1–12 μg/mL for chlordiazepoxide. The obtained results were statistically compared with those of the official methods using Student t-test, F-test, and one way ANOVA, showing no significant difference with respect to accuracy and precision
Stability-indicating chromatographic methods for determination of flecainide acetate in the presence of its degradation products; isolation and identification of two of its impurities
No full textABSTRACT: In this work, two stability-indicating chromatographic methods have been developed and validated for determination
of flecainide acetate (an antiarrhythmic drug) in the presence of its degradation products (flecainide impurities; B and D).
Flecainide acetate was subjected to a stress stability study including acid, alkali, oxidative, photolytic and thermal degradation.
The suggested chromatographic methods included the use of thin layer chromatography (TLC-densitometry) and highperformance
liquid chromatography (HPLC). The TLC method employed aluminum TLC plates precoated with silica gel G.F
as the stationary phase and methanol–ethyl acetate–33%ammonia (3:7:0.3, by volume) as the mobile phase. The chromatograms
were scanned at 290 nm and visualized in daylight by the aid of iodine vapor. The developed HPLC method used a RP-C
column
with isocratic elution. Separation was achieved using a mobile phase composed of phosphate buffer pH3.3–acetonitrile–
triethylamine (53:47:0.03, by volume) at a flow rate of 1.0 mL/min and UV detection at 292 nm. Factors affecting the efficiency
of HPLC method have been studied carefully to reach the optimum conditions for separation. The developed methods were
validated according to the International Conference on Harmonization guidelines and were applied for bulk powder and dosage
form
Health Tracking System [HTS]
No full text The System helps the patients and old aged people to get there,
medicines reserve at clinics keep tracking on their health.
Patients can see their prescriptions.
Patients can see available doctors and reservations
Patients can see their reservations.
The System also helps us to make records on the medical issues
because of the lack we are having on recording medical aspects
and make an easy link between doctor, clinic and pharmacy to
make the life easier and faster.
Also to keep an accurate records with dates and diseases history to
make the patient tracking more easilyProposing problems mentioned above, we propose a web and mobile
application system to link between the patient, clinic, and pharmacy.
The system is giving each part of the user’s different login privileges
based on their roles.
when a patient go to the clinic is usually asked whether he/she has been
registered before or not if so then he will be booked under the scheme
he/she wished, If the patient is not registered, then the nurse will pass him
an application form to fill his/her necessary information to sign her/him
up.
The system will have a lot of doctors that specialist in several fields so the
patient can choose any specialty he/she wants based on what the patient
complains from.
Every doctor has a schedule so the nurse can reserve to the patient in the
schedule if the patient is not registered in the system yet. If the patient is
already registered, he/she can book himself in the doctor schedule that he
wishes. In every schedule the doctor has limits and can easily see the
maximum number of patients.
The system will have a prescription for each patient case, the doctor can
write his prescription for the patient on the web or the mobile application
by searching on the necessary medicine for the current case, the doctor can
easily save the prescription on the system database making sure it couldn't
be damaged or lost
Rational design, synthesis and 2D-QSAR studies of antiproliferative tropane-based compounds†
No full textA GLOBAL INTEGRATED MODEL FOR A TIME-DEPENDENT WELLBORE STABILITY PREDICTION
No full textA Thesis Submitted to the Faculty of Engineering at Cairo University in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCE in PETROLEUM ENGINEERINGThis work presents an integrated wellbore stability model using well log data and a time dependent poroelastic model. An iterative approach was build using MATLAB to determine the optimum wellbore trajectory and safe mud window. Mechanical Earth Model was constructed using log data. Wellbore stresses were determined using the poroelastic constitutive model. Modified Lade Criterion was used to determine the failure conditions of the wellbore walls. The results of the developed model were validated against actual well log data from Gulf of Suez, Egypt.Under the Supervision of Prof. Dr. Eissa Mohamed Shoki
Reinforced concrete project for unit (2) - Factory
No full textDesign all element of structureThe building consists of basment floor, ground floor, first floor, second floor and roof floor. The structure consists of concrete slab floors supported on reinforced concrete beams and columns
On-column decaffeination and HPLC analysis of epigallocatechin gallate in green tea nutraceuticals
No full textGreen tea (GT) derived epigallocatechin gallate (EGCG) is a commonly used nutraceutical for its
antioxidant activity. Caffeine is the second major component and interferes with extraction of
EGCG. On-column decaffeination was optimized to enable selective enrichment of EGCG, though
less retained than caffeine. EGCG recovery and loss in caffeine were determined using RP-HPLC.
Results indicated a significant improvement in caffeine removal and EGCG recovery. The SPE-HPLC
protocol represents a model for an efficient and economic approach for improving dynamic
capacity, selectivity, and sensitivity towards less retained analytes. This is particularly important
for analysis of inherently complex samples of nutraceutical products
An Approach for Managing Requirements Changes in Distributed Agile Development
No full textThe globalization affects many aspects in the process of industrialization development today, one of these industries is the software development industry. Recent years have also witnessed the growth of the agile movement and approaches. Applying the agile approaches and practices in the global or distributed environment will lead to gain a lot of benefits such as reduced costs, higher efficiency and better customization, on the other hand it will face many challenges for example working in different time zones, requirements changes, personal selection and knowledge management. In order to gain these benefits, it should first address the challenges that will face the agile approaches in a distributed environment. One of the main challenges is managing the requirements and its changes during the process of distributed agile software development and the impact of managing requirements on knowledge management between development team. Only few researches of the many approaches and practices published in the literature, addressed the problem of requirements changes during the development process in distributed agile development. Most of the published researches in this context discovered based on industrial experiences and this result in an increase of the need for combining the industry with academia within this area. In our proposed research an approach for distributed agile development to manage requirements and their changes, including the possible changes that have an impact on the knowledge management. Our suggested approach works to cover the gap between the industry and research in distributed agile development by combining the industrial practice and academic technique. Our research aims to develop a software development approach to enhance requirements changes management in distributed agile development
Software Reuse Metrics And Management Decisions
No full textSoftware reuse provides tangible gains in the areas of cost reduction, productivity, quality enhancement of software products. Reuse metrics are used to quantify the effect of the software reuse process and clarifying the benefits it provides. This paper classifies reuse metrics and discusses different models for each metrics so that users can select the most appropriate. It aims to encourage effective software management through adopting effective software reuse as a systematic policy in the organization. It also discusses how to achieve a high level of reuse to get the maximum benefit of reuse process
