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A new Zernike moments based technique for camera identification and forgery detection
No full textIn multimedia forensics, it is important to identify
those images that were captured by a specific camera from
a given set of N data images as well as detecting the tampered
region in these images if forged. This paper presents a
new technique based on Zernike moments feature extraction
for blindly classifying correlated PRNU images as well as
locating the tampered regions in image under investigation.
The proposed clustering algorithm is based on estimating the
Zernike moments and applying a hierarchical clustering for
classification. The forgery detection algorithm is based on
picking up the peak Euclidean distance between the Zernike
moments vector of blocks of the scaled-down forged image
and its corresponding ones in the capturing camera PRNU.
As Zernike moments are scale and rotational invariant, its
feature when computed using scaled-down PRNU images
lead to considerable computation time saving. Simulation
examples are given to verify the effectiveness of the proposed
techniques when compared to other state-of-the-art
techniques even in case of very weakly correlated PRNU
Simultaneous determination of ciprofloxacin hydrochloride and metronidazole in spiked human plasma by ultra performance liquid chromatography-tandem mass spectroscopy
No full textCiprofloxacin HCl (CIP) and Metronidazole (MET) are antibacterial drugs used in combination for treatment of
mixed aerobic/anaerobic infections. An UPLC-MS/MS method was developed for the simultaneous estimation
of CIP and MET in spiked human plasma using sildenafil citrate as an internal standard (IS). Protein
precipitation was used for analyte extraction. The chromatographic separation was completed within 6 min
using a mobile phase of 0.1% formic acid in water and acetonitrile (70: 30, v/v), Zorbax C18, 100 x 4.6 mm,
3.5 µm analytical column, at a flow rate of 0.5 mL min
-1
. Multiple reaction monitoring (MRM) transitions were
measured in the positive ion mode. Validation of the method showed standard curves to be linear in the range of
10-4000 ng mL
-1
for CIP and 30-12000 ng mL
-1
for MET with mean correlation coefficient exceeding 0.999. In
human plasma, CIP and MET were stable for at least 36 days at –70 ± 5 °C, 6 hours at ambient temperature and
after three freeze thaw cycles. After extraction from plasma, the samples were stable in auto sampler at 22 °C
for 6 hours. The method was simple, specific, sensitive, precise, accurate and suitable for bioequivalence and
pharmacokinetic studies
Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression
No full textAIM:
To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic genes abnormalities in rats.
METHODS:
Giving a fructose-enriched diet (FED) to rats for 12 wk was used as a model for inducing hepatic dyslipidemia and insulin resistance. Adult male albino rats (150-200 g) were divided into a control group and a FED group which was subdivided into 4 groups, a control FED, fenofibrate (FENO) (100 mg/kg), resveratrol (RES) (70 mg/kg) and combined treatment (FENO + RES) (half the doses). All treatments were given orally from the 9(th) week till the end of experimental period. Body weight, oral glucose tolerance test (OGTT), liver index, glucose, insulin, insulin resistance (HOMA), serum and liver triglycerides (TGs), oxidative stress (liver MDA, GSH and SOD), serum AST, ALT, AST/ALT ratio and tumor necrosis factor-α (TNF-α) were measured. Additionally, hepatic gene expression of suppressor of cytokine signaling-3 (SOCS-3), sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase (FAS), malonyl CoA decarboxylase (MCD), transforming growth factor-β1 (TGF-β1) and adipose tissue genes expression of leptin and adiponectin were investigated. Liver sections were taken for histopathological examination and steatosis area were determined.
RESULTS:
Rats fed FED showed damaged liver, impairment of glucose tolerance, insulin resistance, oxidative stress and dyslipidemia. As for gene expression, there was a change in favor of dyslipidemia and nonalcoholic steatohepatitis (NASH) development. All treatment regimens showed some benefit in reversing the described deviations. Fructose caused deterioration in hepatic gene expression of SOCS-3, SREBP-1c, FAS, MDA and TGF-β1 and in adipose tissue gene expression of leptin and adiponectin. Fructose showed also an increase in body weight, insulin resistance (OGTT, HOMA), serum and liver TGs, hepatic MDA, serum AST, AST/ALT ratio and TNF-α compared to control. All treatments improved SOCS-3, FAS, MCD, TGF-β1 and leptin genes expression while only RES and FENO + RES groups showed an improvement in SREBP-1c expression. Adiponectin gene expression was improved only by RES. A decrease in body weight, HOMA, liver TGs, AST/ALT ratio and TNF-α were observed in all treatment groups. Liver index was increased in FENO and FENO + RES groups. Serum TGs was improved only by FENO treatment. Liver MDA was improved by RES and FENO + RES treatments. FENO + RES group showed an increase in liver GSH content
Nanomaterials in pharmacology / edited by Zheng-Rong Lu, Shinji Sakuma.
No full textpharmacy bookfair2016Includes bibliographical references and index.xii, 485 p
COMPLETE FIELD DESIGN
No full textOne of the most important and emerging challenges for any petroleum engineer is to improve the evaluation of a reservoir or in another way to describe it with all of its’ parameters and characteristics to find the most efficient applications to improve production, which will help then to increase the profitability of the discovery
COMPLETE FIELD DESIGN
No full textOne of the most important and emerging challenges for any petroleum engineer is to improve the evaluation of a reservoir or in another way to describe it with all of its‘ parameters and characteristics to find the most efficient applications to improve production, which will help then to increase the profitability of the discovery
Bioactive/Natural Polymeric Scaffolds Loaded with Ciprofloxacin for Treatment of Osteomyelitis
No full textLocal delivery of antibiotic into injured bone is a demand. In this work, different
scaffolds of chitosan (C) with or without bioactive glass (G) were prepared using the freezedrying
technique in 2:1, 1:1, and 1:2 weight ratios. Chitosan scaffolds and selected formulas of
chitosan to bioglass were loaded with ciprofloxacin in 5%, 10%, and 20% w/w. Scaffold
morphology showed an interconnected porous structure, where the glass particles were
homogeneously dispersed in the chitosan matrix. The kinetic study confirmed that the
scaffold containing 1:2 weight ratio of chitosan to glass (CG12) showed optimal bioactivity
with good compromise between Ca and P uptake capacities and Si release rate. Chitosan/
bioactive glass scaffolds showed larger t50 values indicating less burst drug release followed
by a sustained drug release profile compared to that of chitosan scaffolds. The cell growth,
migration, adhesion, and invasion were enhanced onto CG12 scaffold surfaces. Samples of
CG12 scaffolds with or without 5% drug induced vascular endothelial growth factor (VEGF),
while those containing 10% drug diminished VEGF level. Only CG12 induced the cell
differentiation (alkaline phosphatase activity). In conclusion, CG12 containing 5% drug can
be considered a biocompatible carrier which would help in the localized osteomyelitis
treatment
Home automation and security
No full textThe main objective in this project is to modernize any home in order to make life more convenient. And to make a full access to all features of this smart home with different platforms (e.g. PC, web application, Android mobile application) In order to carry out this work, a suitable design for house consisting of bedroom, living, kitchen, reception and garden was made to work as a model to simulate the real life and real controlling of the home features.
The Project mainly focuses on the controlling of Light, Air conditioner, fan and providing security (camera) by the user away from his home or place .This system is depending on the microcontroller (Arduino) that is like a small computer that controls any device automatically without any human interference that the user could control any device at home from his Mobile Phone. This system provides ideal solution to the problems faced by home owners (user) in daily life.
The system is consists of hardware and software development, a controlling system that works on clicking on the ON and OFF buttons on the Android Application that takes the Public IP address that connected the Router (Internet) in the place that the Arduino exist, where the Arduino is connected to the devices through the Relay board, That help the user to be more safer and comfortable to make life easy to him
Bioorganic & Medicinal Chemistry Letters
No full textA new series of 2,3,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for
their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 28 and 61 proved
to be active DHFR inhibitors with IC50 0.02 and 0.01 µM, respectively. Molecular modeling studies
concluded that recognition with the key amino acid Phe34 is essential for binding and hence DHFR
inhibition. Compounds 34, 56 and 66 showed broad spectrum antimicrobial activity comparable to
Gentamicin and Ciprofloxacin. Compounds 40 and 64 showed broad spectrum antitumor activity
toward several tumor cell lines and proved to be 10 fold more active than 5-FU, with GI50 MG-MID
values of 2.2 and 2.4 µM, respectively
روح أكتوبر 73 والأمن القومي : الدور الأقليمي المركزي لمصر
No full textتقديم - إرهاصات الحرب - المناورات والإعداد للحرب - القتال من أجل تحرير سيناء والسيادة المصرية عليها- الإنسان المصري والتفاني من أجل تحرير الوطن- الدبابات الهيكلية والتمسك بالأرض- موافق إنسانية - تنسيق إستراتيجي عربي نادر - وح أكتوبر والدروس المستفادة - الأمن القومي المصري - الأمان الإنساني - الأمن القومييتناول هذا الكتاب حرب أكتوبر المجيدة في تاريخ الحروب العسكرية ويوضح الروح القتالية الخاصة بالجندي المصري والأمن القومي الخاص بمصر في الفترة الخاصة بحرب أكتوبر 1973 كما يوضح السياسات الأمنية في تلك الفترة والدور الإستراتيجي العربي والتنسيق بين الجهات العربي