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In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration
No full textDiltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass
metabolism and low oral bioavailability. The aim of this work was to develop niosomes for
potential nasal delivery of DTZ. Niosomes protect hydrophilic drugs inside their core while nasal
route offers both rapid onset and evasion of first-pass metabolism. Niosomes were prepared
using a combination of Span 60 or Brij-52 with cholesterol (CHOL) in different molar ratios
followed by determination of entrapment efficiency, particle size and in vitro drug release. A
parallel design was adopted to evaluate the pharmacokinetic performance of DTZ-loaded
niosomes in male Wistar rats. Non-compartmental analysis was performed where Cmax, Tmax,
t1/2, MRT, area under the release curve (AUC) and Ke were assessed. The prepared niosomes
were spherical with mean particle size 0.82–1.59 mm. Span 60-cholesterol niosomes (1:1 molar
ratio) showed the highest entrapment and release efficiencies. In vivo study revealed an
increase in MRT, t1/2 and AUC with a decrease in Ke. In conclusion, nasal niosomal formulation of
DTZ expressed suitable pharmacokinetic parameters and bioavailability through prolonged
duration of action inside the body as well as low rate of elimination depicting a promising
alternate to the conventional oral route
Foliar spraying of salicylic acid induced accumulation of phenolics, increased radical scavenging activity and modified the composition of the essential oil of water stressed Thymus vulgaris L
No full textPolyphenolic compounds are considered valuable secondary plant metabolites owing to the myriad of biological
activities they exert. This study aimed to investigate the effect of applying various concentrations of the plant
growth regulator, salicylic acid (SA), on Thymus vulgaris L. while subjecting the plant to decreasing amounts of
irrigation water. The following parameters were monitored; total polyphenolic and flavonoid content, yield and
composition of the essential oil, and antioxidant activity of the alcoholic extracts. Drought alone significantly
(P < 0.05) increased the polyphenolic and flavonoid content, yield of the essential oil and antioxidant activity.
The total flavonoid content in control plants was 6.1 ± 0.3 mg/gm dry weight calculated in terms of rutin
equivalent. However, in drought stressed plants, (irrigated at 25% of the field capacity) sprayed with 3 mM SA,
the flavonoid content increased to 32.1 ± 0.1 mg/gm dry weight calculated in terms of rutin equivalent.
Moreover, the total phenolic content increased from 8.5 ± 0.3 to 68.5 ± 1.2 mg/gm dry weight calculated in
terms of gallic acid in the same test plants. Radical scavenging activity, using DPPH assay, was measured for the
different plant treatments. A decrease from 74.4 ± 0.4 μg/ml to 36.6 ± 0.9 μg/ml of IC50 was recorded in the
drought stressed plants (25% FC) sprayed with 3 mM SA compared with the control plants. The variability in
polyphenolic composition between the control plants and plants with the highest total polyphenolic content was
investigated by UPLC-ESI-MS/MS. Rosmarinic acid was detected as the major component in samples from both
treatments, with a higher percentage observed upon subjecting the plant to the test conditions (25% FC and
sprayed with 3 mM SA). The highest yield of the essential oil (1 ± 0.06 %v/w) was obtained from drought
stressed plants (25% FC) sprayed with 2 mM SA. GC/MS analysis of oil samples revealed that the Thymol content
increased with drought stress, while that of p-cymene decreased. However, an increase of p-cymene was witnessed
as a result of SA sprayin
Future Computing and Informatics Journal Volume 2, Issue 2
No full textArticles : Wavelet based transition region extraction for image segmentation -- A novel fuzzy logic based reverse engineering of gene regulatory network -- A new method to reduce the effects of HTTP-Get Flood attack -- Informative gene selection using Adaptive Analytic Hierarchy Process (A2HP) -- A thresholding based technique to extract retinal blood vessels from fundus images -- Pentagonal fuzzy number, its properties and application in fuzzy equation -- Feature level review table generation for E-Commerce websites to produce qualitative rating of the products -- A framework for safer driving in Mauritius -- An improved rank based disease prediction using web navigation patterns on bio-medical databases -- A robust 3D mesh watermarking algorithm utilizing fuzzy C-Means clusteringFuture Computing and Informatics Journal (FCIJ) is an International Journal, a scholar open access, peer-reviewed, interdisciplinary, and fully referred international scientific journal focusing on research in computer science, information systems, information technology, and relative fields. FCIJ aims to contribute in promoting the research in the field of applied computing and information technology.
The journal Scope covers the whole areas of computer science, information systems, and information technology like Management of Green IT, Artificial Intelligence, Embedded Systems, Mobile Computing, Knowledge Discovery and Data Mining, Software Engineering, Data and Network Security, Human-Computer Interaction, Computational Intelligence, Biometrics and Bioinformatics, Database Management Systems and more.Future University In Egyp
A Cloud Computing-Based Model of E-Commerce Adoption for Developing Countries
No full textJournal of Electronic Commerce in Organizations Volume 15 • Issue 3 • July-September 2017Whilee-commerce can contribute significantly to the economies of developing countries challenges may include a lack of telecommunications infrastructur
Predicting Stock Market Behavior using Data Mining Technique and News Sentiment Analysis
No full textInternational Journal of Intelligent Systems and Applications (IJISA) · July 2017 Stock market prediction has become an attractive investigation topic due to its important role in economy and beneficial offers. There is an imminent need to uncover the stock market future behavior in order to avoid investment risks. The large amount of data generated by the stock market is considered a treasure of knowledge for investors. This study aims at constructing an effective model to predict stock market future trends with small error ratio and improve the accuracy of prediction. This prediction model is based on sentiment analysis of financial news and historical stock market prices. This model provides better accuracy results than all previous studies by considering multiple types of news related to market and company with historical stock prices. A dataset containing stock prices from three companies is used. The first step is to analyze news sentiment to get the text polarity using naïve Bayes algorithm. This step achieved prediction accuracy results ranging from 72.73% to 86.21%. The second step combines news polarities and historical stock prices together to predict future stock prices. This improved the prediction accuracy up to 89.80%
Achieving Net Zero-Energy Buildings through Retrofitting Existing Residential Buildings Using PV Panels
No full textThe study starts with the analysis of the current situation of both the existing buildings and the energy sector in Egypt, analyzing
the energy consumption patterns and the inefficiencies leading to these patterns, then defining the nZEB concept to familiarize the
reader with its different aspects. The empirical part of the study utilizes simulation to validate the proposed guideline by applying
it on an already existing residential building. The detailed steps of converting an already existing residential building to an nZEB
is the final outcome of the research
The effect of different insertion techniques on the depth of cure and vickers surface micro-hardness of two bulk-fill resin composite materials
No full textBackground: The aim of this study was to evaluate the Vickers surface micro-hardness and the depth of cure of two bulk-fill resin composites and one incremental-fill resin composite.Material and Methods: Two Bulk-fill dental resin composites (X-tra Fil, Voco; Sonic-FillTM 2, Kerr Corporation) and an incremental-fill dental resin composite (Filtek™ Z250 XT, 3M ESPE) were used. Sixty cylindrical speci- mens of 4 mm thickness were prepared using split Teflon moulds. Specimens were divided into six groups (n=10) according to the type of the material used and according to the insertion technique applied (bulk or incremental). Prepared specimens were stored dry in complete darkness at 37°C for 24 hours. All specimens were tested for their Vickers surface micro-hardness, on their top and bottom surfaces. The depth of cure of the tested specimens was assessed by calculating the hardness ratio for each specimen. The Vickers surface micro-hardness and depth of cure data were analyzed for normality using Kolmogorov-Smirnov and Shapiro-Wilk tests. Independent sample-t test was used to compare between two groups while One-way ANOVA was used to compare between more than two groups.Results: Significant difference in the Vickers surface micro-hardness and depth of cure values was demonstra- ted among the tested materials (P<0.0001). X-tra Fil recorded the highest mean Vickers micro-hardness value (94.05±1.05). Bulk-fill dental resin composites X-tra Fil and Sonic-Fill showed 0.980±0.005 and 0.921±0.020 depth of cure values (bottom/top hardness ratio) respectively while Z250 XT recorded 0.776±0.141.Conclusions: X-tra Fil showed highest Vickers surface micro-hardness values on both top and bottom surfaces, whether inserted in increments or bulk. Both bulk-fill resin composites showed higher depth of cure for both inser- tion techniques
Non-ionic Surfactant Based In Situ Forming Vesicles as Controlled Parenteral Delivery Systems
No full textNon-ionic surfactant (NIS) based in situ forming vesicles (ISVs) present an
affordable alternative to the traditional systems for the parenteral control of drug release. In
this work, NIS based ISVs encapsulating tenoxicam were prepared using the emulsion
method. Tenoxicam-loaded ISVs were prepared using a 22
.31 full factorial experimental
design, where three factors were evaluated as independent variables; type of NIS (A), molar
ratio of NIS to Tween®80 (B), and phase ratio of the internal ethyl acetate to the external
Captex® oil phase (C). Percentage drug released after 1 h, particle size of the obtained
vesicles and mean dissolution time were chosen as the dependent variables. Selected
formulation was subjected to morphological investigation, injectability, viscosity
measurements, and solid state characterization. Optimum formulation showed spherical
nano-vesicles in the size of 379.08 nm with an initial drug release of 37.32% in the first hour
followed by a sustained drug release pattern for 6 days. DSC analysis of the optimized
formulation confirmed the presence of the drug in an amorphous form with the nano-vesicles.
Biological evaluation of the selected formulation was performed on New Zealand rabbits
by IM injection. The prepared ISVs exhibited a 45- and 28-fold larger AUC and MRT values,
respectively, compared to those of the drug suspension. The obtaine
A Novel Method for Preparing Surface-Modified Fluocinolone Acetonide Loaded PLGA Nanoparticles for Ocular Use: In Vitro and In Vivo Evaluations
No full textBiomaterial scaffolds are versatile tools as drug carrier for treatment of wounds. A series of norfloxacin-loaded scaffolds were synthesized for treatment of wounds by combining collagen with two different types of chitosan using freeze-drying technique. Subsequently, scaffolds were screened in terms of morphology, water absorption and retention capacity, biodegradation, ex-vivo bioadhesive strength, in-vitro drug release biological compatibility, X-ray diffractometry, differential scanning calorimetry as well as in-vivo evaluation. The results indicate that the scaffold mechanical strength is dependent on the type of used chitosan. The prepared scaffolds contained interconnected porous architecture. The scaffolds had high water uptake and retention capacity with extended biodegradation rate. Scaffolds prepared with chitosan HCl showed superior bioadhesive strength compared to those prepared with low molecular weight chitosan. All scaffolds showed almost 100% drug release within 24h. As identified by the terahertz pulsed imaging measurements, there is single scaffold area with the same concentration. After 28 days of wound dressing with selected norfoloxacin-loaded or unloaded collagen/chitosan scaffolds in Albino rats, it was found that the tissue regeneration time was fast compared to non-treated wounds. Furthermore, the drug-loaded scaffolds showed normal structure of an intact epidermal layer as well as the underlying dermis as revealed by histopathological studies. The obtained results suggest that the investigated norfloxacin-loaded collagen/chitosan scaffold is a potential candidate for skin regeneration application
Quercetin and tin protoporphyrin attenuate hepatic ischemia reperfusion injury: role of HO-1
No full textNaunyn-Schmiedeberg's Arch Pharmacol (2017) 390:871–881 DOI 10.1007/s00210-017-1389-