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Don’t assume, ask! A focus group study on end-of-life care planning with people with intellectual disabilities from minoritised ethnic groups
No full textStudent midwives' experiences of high-fidelity simulation in midwifery education in the university setting : a qualitative systematic review
No full textHigh- Fidelity Simulation is an increasingly popular, evidence-based, and technologically sophisticated pedagogical approach within nursing and midwifery education and simulated practice learning. Various systematic reviews exploring the effectiveness of High- Fidelity Simulation have been undertaken, yet there is limited evidence and no current systematic review about student midwives' experiences of High- Fidelity Simulation. Due to this lack of evidence, the proposed review into student midwives' experiences of High- Fidelity Simulation is highly justified. This review aims to provide new insights into this pedagogical approach within midwifery education and shape recommendations to assist midwifery educators to deliver high-quality High-Fidelity Simulation. The Joanna Briggs Institute (JBI) methodology for qualitative systematic reviews was followed and the study is reported using the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) guidelines. The review found High- Fidelity Simulation to be a beneficial learning process, however some negative experiences were also identified. Two main themes emerged related to barriers and facilitators. Facilitators included the following seven subthemes: practical skill development, authenticity of the manikin and surroundings, application of theory to practice, increased confidence, practicing in a safe learning environment, improved team working skills, and the value of feedback. Barriers included the following 5 subthemes: a lack of realism, stress and pressure whilst role playing, anxiety, feelings of guilt, shame and decreased self-esteem, and group allocation. Overall, the synthesized findings highlight that student midwives perceive the use of High- Fidelity Simulation to be highly beneficial, positively impacting their clinical competence and team working skills. Moreover, if High- Fidelity Simulation was used consistently and alongside adequate preparation and debriefing processes any unnecessary emotional harm could be avoided. Therefore, the application of High-Fidelity Simulation has the potential to develop a midwifery workforce that is better equipped to practice safely and more effectively at the point of registration, which could reduce mortality and morbidity rates for women and babies
Comparative study of different engine knock metrics for bracketing the octane number of fuels
No full textA personalised health intervention to maintain independence in older people with mild frailty : a process evaluation within the HomeHealth RCT
Full text linkFrailty is common in later life and can lead to adverse health outcomes. Services aimed at preventing decline in early stages of frailty may support older people to remain independent for longer. We developed and tested a new service, HomeHealth, in a randomised controlled trial. HomeHealth was a multidomain behaviour change service based in the voluntary sector in England targeting mobility, socialising, nutrition and psychological well-being
Engineering pH-dependent orally disintegrating tablets for modified indomethacin release : a polymer-based approach
No full textThe application of pH-sensitive polymers has been widely explored in pharmaceutical industry because of their versatile properties. This work aims to delay the release of indomethacin (IND), a commonly used anti-inflammatory drug, using a pH-dependent polymer within orally disintegrating tablets (ODTs) and to investigate the effect of the polymer particle size on the ODTs. When developing delayed-release formulations for orally disintegrating tablets (ODTs), it's essential to balance the pellet's matrix properties to maintain integrity and delayed release. Different sizes of Eudragit L100 were used to create IND-containing pellets via extrusion spheronization, which were then embedded into the matrix of ODTs. The particle sizes displayed good elastic properties with low Young's modulus (YM) values, and there was no significant difference between the different sizes (45, 60, 93 µm; p > 0.05). The tensile strength of the pellets was directly proportional to YM (p < 0.05), providing enough support to maintain their integrity under compression. Pellets made from 63 µm Eudragit L100 had a suitable balance of mechanical and pharmaceutical properties compared to other sizes. 63 µm pellets had an aspect ratio of 1.49 ± 0.26 and 61% yield, while their ODTs showed a fast disintegration time of 14 ± 0.6 s, while modifying the drug release. Furthermore, IND exhibited modified release in acidic media (pH 1.2) and immediate release in buffer media (pH 6.8). Overall, protecting pellet integrity was crucial to delay release in acidic media and enable immediate release in alkaline media. The newly developed formulation will improve compliance and reduce side effects associated with IND and other irritant drugs particularly in elderly populations
Preparation of 6, 8-dithiooctanoic acid-functionalized copper nanoclusters with near-infrared emission : application for determination of melamine in food matrices
No full textThe impact of mergers and acquisitions on shareholder wealth of acquiring companies in the mining industry
No full textThis study explores the impact of mergers and acquisitions (M&As) on acquirer shareholders' wealth in the global mining industry. Using an event study approach on a sample of 9,806 M&A deals from 1990 to 2014, we find that mining industry acquirers generally experience positive abnormal returns (AR) around the announcement date. Notably, the M&A wealth effect varies significantly based on specific deal characteristics. Cross-border acquisitions, focus-increasing acquisitions, and acquisitions resulting in full ownership of the target yield higher abnormal returns. Conversely, large deals often result in lower returns. These findings highlight the role of strategic decision-making in M&A transactions within the mining industry, with implications for both industry practitioners and policymakers
Failing to eradicate vaccine-type HPV : the long-term fiscal burden of neglecting a public good
No full textMeasuring objective image and video quality : on the relationship between SSIM and PSNR for DCT-based compressed images
Full text linkThe final rhyme (or the community of lament) : Benjamin’s Shakespearian sonnet cycle
Full text linkDeparting from Benjamin’s use of the Shakespearean sonnet form in his own sonnet cycle, the article proposes some sources for this use and reflects on its significance for the wider understanding of Benjamin’s poetic work. It situates this use within the tradition of German translations of Shakespeare’s Sonnets and German language Shakespeare scholarship. It asks about the memorial function of the cycle for the death of Benjamin’s friends Heinle and Seligson in a suicidal gesture against the outbreak of the First World War and links the sonnets to Benjamin’s writings on Hölderlin and lament, provoked by the same event