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The troublesome nature of learning to teach critical thinking : using threshold concepts theory to support teacher education
No full textThe cost of uncertainty : analysing the influence of coal price changes, the Russia-Ukraine war and geopolitical risk on risk premiums in Indian electricity spot market
No full text‘This your strike is affecting our children’ : a story of a host community’s intervention on the front line of university–workers disputes in southwest Nigeria.
Full text linkWhile it is common to regard the traditional actors such as the employers and their representatives, employees and their representatives, and the state as the main actors in industrial relations (IR), this on-the-frontline article shows that host communities (HCs) can be recognised as IR actors in their own right. This article illustrates that the interventions of HCs in IR can be independent – contrary to how HCs are characterised as subordinates to trade unions in community unionism literature. Through Biobaku’s accounts of the interventions of a university’s host community from the Yorùbá society of southwest Nigeria, this article offers empirical contributions to the literature of neo-pluralism and decolonisation of IR in the context of the Global South, where formal and indigenous actors co-form the IR system
Pomegranate extracts as dual regulators of angiogenesis : a systematic review of preclinical evidence in cancer and chronic wound healing
No full textAngiogenesis plays a critical role in both tumor progression and wound healing. This systematic review investigates the effect of pomegranate (Punica granatum, PG) extracts as both anti- and pro-angiogenic agents in preclinical models of cancer and chronic wound healing (CWH), respectively. Following PRISMA guidelines, 14 studies (10 cancer, 4 CWH) were identified from PubMed, Scopus, and Google Scholar databases. In cancer models, PG extracts (juice, peel extract, seed oil) reduced vascular endothelial growth factor (VEGF) expression, and endothelial tube formation across multiple cancer types, with concomitant decrease in matrix metalloproteinases and inflammatory mediators. Conversely, in CWH models, topical PG peel extract applications enhanced VEGF expression and wound closure in diabetic and burn injuries. This dual angiogenic effect appears mechanistically linked to peroxisome proliferator-activated receptor signaling pathways and synergistic interactions among PG polyphenols, particularly ellagitannins. Assessment of study quality revealed generally low risk of bias across in vitro studies, while animal studies demonstrated variable methodological rigor. Despite promising preclinical evidence, standardization of extraction methods, exploration of molecular mechanisms, and translation to clinical investigations remain critical research priorities. This comprehensive analysis validates PG extracts as a promising therapeutic strategy for both inhibiting pathological angiogenesis in cancer and promoting beneficial angiogenesis in CWH
How natural therapies can combat neoplastic disease by targeting key survival mechanisms and signaling pathways
Full text linkPlant extracts are increasingly becoming an answer to expensive, high-dose, synthesized chemotherapy, with milder side effects and easier accessibility. Many botanical plants contain active ingredients, such as terpenoids and alkaloids, which may combat cancer; however, studies need to be performed to test whether they are solely effective enough and whether the extracted compounds are selective for the tumor itself. Many chemotherapy drugs were initially of botanical origin, such as vincristine from Catharanthus roseus and paclitaxel from the Taxus baccata tree. The objective of this review is to assess the mechanisms of herbal therapeutics in their role against malignancy. Ajwa, curcumin, ginseng, lycopene, and ursolic acid were all respectively evaluated in the paper for their prevalent properties, their method of extraction, notable usage in medicine, which pathways they activate, and whether the transductions can disrupt cancer formation or proliferation. The findings from the review demonstrated that all the therapeutics exhibited pro-apoptotic behavior, Ajwa and curcumin exerted cell cycle arrest upon neoplasms, and Ajwa, curcumin, and lycopene showed anti-metastatic behavior. Most extracts were tested on colorectal cancer, and the pathways most commonly applied were through BAX/Bcl2 and endoproteases, such as caspase-3 and caspase-9, indicating predominantly mitochondrial apoptosis. In addition, cell cycle arrest was noted to occur during the G2/M phase via Wnt/β-catenin in both curcumin and ginseng, independently of the Wnt/β-catenin pathway in Ajwa constituents, reducing cell viability. All of these studies were demonstrated in vitro within varieties of single cell cultures, which did not take into account bioavailability nor properly demonstrate the tumor microenvironment, which may not yield the same results in vivo. Clinical trials need to be undergone to appropriately test effective dosages, as if a compound is strongly pro-apoptotic, it may not be selective just to tumor cells but also to healthy cells, which may impair their functions
Computer simulation and speedup of solving heat transfer problems of heating and melting metal particles with laser radiation
No full textThe study of the process of laser action on powder materials requires the construction of mathematical models of the interaction of laser radiation with powder particles that take into account the features of energy supply and are applicable in a wide range of beam parameters and properties of the particle material. A model of the interaction of pulsed or pulse-periodic laser radiation with a spherical metal particle is developed. To find the temperature distribution in the particle volume, the non-stationary three-dimensional heat conductivity equation with a source term that takes into account the action of laser radiation is solved. In the plane normal to the direction of propagation of laser radiation, the change in the radiation intensity obeys the Gaussian law. It is possible to take into account changes in the intensity of laser radiation in space due to its absorption by the environment. To accelerate numerical calculations, a computational algorithm is used based on the use of vectorized data structures and parallel implementation of operations on general-purpose graphics accelerators. The features of the software implementation of the method for solving a system of difference equations that arises as a result of finite-volume discretization of the heat conductivity equation with implicit scheme by the iterative method are presented. The model developed describes the heating and melting of a spherical metal particle exposed by multi-pulsed laser radiation. The implementation of the computational algorithm developed is based on the use of vectorized data structures and GPU resources. The model and calculation results are of interest for constructing a two-phase flow model describing the interaction of test particles with laser radiation on the scale of the entire calculation domain. Such a model is implemented using a discrete-trajectory approach to modeling the motion and heat exchange of a dispersed admixture
