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Drug repurposing : exploring potential anti-cancer strategies by targeting cancer signalling pathways
No full textThe repurposing of previously clinically approved drugs as an alternative therapeutic approach to treating disease has gained significant attention in recent years. A multitude of studies have demonstrated various and successful therapeutic interventions with these drugs in a wide range of neoplastic diseases, including multiple myeloma, leukaemia, glioblastoma, and colon cancer. Drug repurposing has been widely encouraged due to the known efficacy, safety, and convenience of already established drugs, allowing the bypass of the long and difficult road of lead optimization and drug development. Repurposing drugs in cancer therapy is an exciting prospect due to the ability of these drugs to successfully target cancer-associated genes, often dysregulated in oncogenic signalling pathways, amongst which are the classical cancer signalling pathways; WNT (wingless-related integration type) and Hippo signalling. These pathways play a fundamental role in controlling organ size, tissue homeostasis, cell proliferation, and apoptosis, all hallmarks of cancer initiation and progression. Prolonged dysregulation of these pathways has been found to promote uncontrolled cellular growth and malignant transformation, contributing to carcinogenesis and ultimately leading to malignancy. However, the translation of cancer signalling pathways and potential targeted therapies in cancer treatment faces ongoing challenges due to the pleiotropic nature of cancer cells, contributing to resistance and an increased rate of incomplete remission in patients. This review provides analyses of a range of potential anti-cancer compounds in drug repurposing. It unravels the current understanding of the molecular rationale for repurposing these drugs and their potential for targeting key oncogenic signalling pathways
Negotiating the budget for evidence-informed policymaking : insights from a UK government department
No full textBook Review of 'How big things get done : the surprising factors behind every successful project, from home renovations to space exploration' by Bent Flyvbjerg and Dan Gardner
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Understanding the post-COVID-19 environment to better support our students: a collaborative study
No full textDesign and preparation of a fluorescent molecularly imprinted membrane for the selective detection of pepsin enzyme as a biomarker for gastroesophageal reflux disease
No full textMoving beyond myths and realities : impact of the 5C’s strategies on the internationalization of higher education in the context of COVID-19
No full textThe COVID-19 pandemic impacted almost all areas of our lives, including the internationalisation of higher education. Therefore, enabling the internatio�nalisation of higher education is one of the biggest challenges for academic institutions, and in this context, there is a need to move beyond myths and realities. Owing to the scarcity of research in the domain, this study aims to identify various critical strategies and empirically examine their impact on the internationalisation of higher education. For this purpose, a comprehensive literature review was conducted to explore strategies and develop a theoretical framework. To test research hypotheses, this study employed an explanatory research design utilising a survey instrument methodology to collect data from 253 respondents from both the public and private sector universities in Pakistan. The measures of the internationalisation of higher education were adopted from earlier studies while an instrument was developed to measure strategies on a 5-point Likert scale. The reliability and validity of data were ensured, and correlation and regression analyses were utilised to test hypotheses, in addition to validation of hypotheses through AMOS and PLS-SEM. Findings revealed a significant and positive impact of communicating, cooperating, coordinating, collaborating, and continuing strategies (5C’s) in enhancing the internationalisation of higher education. Also, the finding implies that an integrated policy through the adoption of the 5C’s strategies needs to be implemented by academic institutions to overcome the challenges of the internationalisation of higher education
