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Synthesis and evaluation of druglike parameters via 'in silico' techniques for a series of heterocyclic monosquarate-amide derivatives as potential carboxylic acid bioisosteres
No full textHerein, we present a synthetic compound library comprising of 13 structurally diverse heterocyclic monosquarate-amide derivatives. The compounds featured in this library were designed as potential bioisosteric replacements carboxylic acid moiety’s. A good selection of the compounds presented exhibit unique molecular architecture and have shown promising results following in silico evaluation of ‘druglike properties’ using Swiss ADME. The research presented in this work focuses on the preparation of derivatives of 3,4-dihydroxycyclobut-3-ene-1,2-dione, a known carboxylic acid bioisostere
Book Review of: 'The Poetics of Cruising: Queer Visual Culture from Whitman to Grindr' by Jack Parlett
No full textHow workers meet new expertise needs throughout their careers : an integrative review revealing a dynamic process model of flexpertise
No full textA “show and tell” : innovative ways to teach physiology
No full textA session showcasing innovative approaches to teaching, including how to integrate playful and artistic learning techniques into your teachin
Pauses - inventory of behaviours
No full textInventory of Behaviours (IOB) is an evolving artwork consisting of instructions written by artists that detail how to reproduce their behaviours in the studio. Preliminary research through IOB has revealed that artists’ encounters with matter, with concepts, with process (production) are frequently prefaced, punctuated and concluded by apparently unrelated and often habitual activity (peripheral). For Doing Together 2024, IOB introduced x3 spaces to PAUSE. IOB invited participants to use materials and autotelic actions to reflect on and share their own periphery behaviours
Transphobic hate crime, intersectionality, and the evolution of LGBT+ officers in England
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