36057 research outputs found
Sort by
Development and characterization of three novel FGFR inhibitor resistant cervical cancer cell lines to help drive cervical cancer research
Get PDFPrimary or acquired resistance to therapeutic agents is a major obstacle in the treatment of cancer patients. Cervical cancer is the fourth leading cause of cancer deaths among women worldwide and, despite major advances in cancer screening and treatments, many patients with advanced stage cervical cancer have a high recurrence rate within two years of standard treatment, with drug resistance being a major contributing factor. The development of cancer cell lines with acquired resistance to therapeutic agents can facilitate the comprehensive investigation of resistance mechanisms, which cannot be easily performed in clinical trials. This study aimed to create three novel and robust cervical cancer cell lines (HeLa, CaSki, and SiHa) with acquired resistance to a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor (PD173074). All three drug-resistant (DR) cell lines overexpressed FGFR1, FGFR2, FGF2, FGF4, and FGF7 proteins that were also localized to the nucleus. In addition, the DR cells had a significantly more aggressive phenotype (more migratory and proliferative, less apoptotic) compared to the parental cell lines. These novel DR cervical cancer cells are a critical tool for understanding the molecular mechanisms underpinning drug resistance and for the identification of potential cervical cancer biomarkers. Moreover, the availability of such DR cell lines may facilitate the development of more effective therapeutic strategies using FGFR inhibitors in combination with other agents that target pathways responsible for acquired resistance to FGFR inhibitors
Enhancing maternity healthcare workers’ wellbeing using insider participatory action research
Get PDFMaladaptive daydreaming and psychopathology : a meta-analysis
Get PDFMaladaptive daydreaming (MD) is a clinical condition that cannot be explained by any existing psychopathology. The empirical literature regarding MD suggests that it is associated with mental afflictions and exhibits attributes resembling a psychological disorder. This study aimed to meta-analytically investigate the relationship between MD and various manifestations of mental distress and dysfunction. Forty studies, totaling 24,977 individuals (Mean(age) = 28.75, SD = 9.90), met our eligibility inclusion criteria and were incorporated in the analyses. Findings revealed that MD is positively associated with depression, anxiety, dissociation, obsessive-compulsive disorder, attention deficit/hyperactivity disorder, general psychopathology, psychotic symptoms, autism spectrum disorder and traumatic experiences. Some effects were moderated by sample type, age and gender. Our secondary analyses examined other psychological problems. We found a positive association between MD and difficulties in emotion regulation, loneliness, dysfunctional personality traits, negative affect, pathological celebrity worship, personality disorder, shame, somatic symptoms, problematic internet use and psychological distress. Additionally, there was a negative association between MD and self-efficacy and self-esteem. Our findings suggest that MD behaves like other DSM disorders by showing comorbidity with various psychopathologies. Theoretical and clinical implications of these findings are discussed
University mathematics lecturers’ experiences of teaching and learning during COVID-19 pandemic : a comparative study between Kuwait and United Kingdom
Get PDFNumerical and experimental study on the influence of thermal behavior of phase change plate in high temperature and low ventilation speed environment
No full textScoping review identifying interventions that have been tested to optimise the experience of people from ethnic minority groups receiving systemic anticancer therapy (SACT)
No full textEthics and health informatics in contemporary healthcare delivery : evaluating collaborative student engagement through virtual learning
Get PDFContemporary learning has changed the dynamic of how students acquire new knowledge, and the prevalent use of social media has influenced the way in which students develop insight and learn new theoretical knowledge. Graduate students obtaining degrees in the field of healthcare, health sciences, and related allied health professions, are academically and professionally prepared to address complex challenging scenarios in varied healthcare settings using diverse learning strategies. The aim of this project was to explore student engagement when using a virtual discussion forum to discuss the principles of ethics and health informatics in contemporary healthcare delivery. Methods: This was a retrospective process evaluation on student engagement when using a virtual discussion forum to discuss ethics and health informatics in contemporary healthcare delivery. Results: Two main themes emerged from this process evaluation. Critical reflective dialogue on ethics and health informatics was evident through student interaction and the ability to reflect on personal experiences relating to the concepts explored. Interactive peer learning using critical reflection techniques supported the process of academic critical reasoning within the discussions. The critical reflection technique was student-led and independently facilitated to promote an engaging virtual learning environment. Conclusion: The critical reflective dialogue promoted a peer learning, student-led experience that was supported by Socratic questioning. Interactive peer learning was evident as the critical reflective technique enabled students to receive real-time feedback from their peers relating to ethics and health informatics through virtual learning
