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Crotoscheffleriolides, ent-clerodane diterpenoids from Kenyan Croton scheffleri
No full textKenyan Croton scheffleri has yielded nineteen compounds. The stem bark gave six undescribed ent-clerodane diterpenoids (1-4, 6 and 7), three undescribed sesquiterpene lactones (9, 11 and 12) and four known compounds (5, 8, 10 and 13). From the leaves six known compounds were identified, ayanin (14), pheophytin a (15), ferulic acid (16), 1,3,4-trihydroxybenzene (17), sitosterol (18), and podosterol (19). The structures of the compounds were determined using spectroscopic and spectrometric methods, NMR, IR, UV, polarimetry, ECD, HRESIMS, and GC-MS. The undescribed compounds were assessed against HIV-1 Reverse Transcriptase and both gram-positive bacteria Staphylococcus aureus 29213 and Enterococcus faecalis 29212, as well as gram-negative bacteria Escherichia coli 25922 and Pseudomonas aeruginosa 27853. Compounds 1, 4, 5, 6, 7, 10, 12 and 19 increased the proliferation of serum starved dermal fibroblast cells at a concentration of 100 nM. All compounds inhibited human dermal fibroblast cell proliferation at 100 μM, while compounds 1, 4 and 19 inhibited fibroblast proliferation at 10 μM
Factors affecting engagement in screening clinics ; exploring the experiences of patients with rare endocrine gene disorders
Full text linkThe aim was to explore the patient experience of those attending screening appointments for rare endocrine syndromes. Obtaining insights into the factors that potentially enhanced or detracted from attendance and engagement with the clinics could assist in developing strategies to promote patient engagement. A qualitative approach using semi-structured interviews was employed to understand individuals’ perceptions and experience of the screening clinics. Twelve interviews were conducted with patients (age 10-66 years, purposive sampling). Four main themes were identified: (1) Perception at a distance, (2) Seeing my future self (3) The body and person in clinic and (4) The patient or doctor, who knows best? These highlighted several areas which could be used to inform approaches to promote enhanced patient engagement: the importance of careful management of projections of self, balancing information overload and honesty, interpersonal relationships and humanisation of care and assisting with the early navigation for the non-expert individual
Retinal vasculometry associations with cognition status in UK Biobank
No full textRetinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale. One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95%) participants (mean age 56.6 years, 55.5% female) were analyzed. A one SD increase in cognition score was strongly associated with increased arteriolar width, arteriolar tortuosity, increased venular width particularly among those 50 years; also, inversely associated with venular tortuosity, and arteriolar and venular width variance
A novel route for fabrication of yellow emissive carbon dots for selective and sensitive detection of vitamin B12
No full textThe co-expression and cellular location of HER family members, EGFRvIII, putative cancer stem cell biomarkers CD44 and CD109 in patients with glioblastoma, and their impacts on prognosis
No full textGlioblastoma multiform is the most aggressive type of brain tumour. The expression of epidermal growth factor receptor (EGFR) and its mutated form EGRRvIII has been reported in patients with a brain tumour, but none of their inhibitors has been approved for the treatment of patients with a brain tumour. This study examined whether the expression of EGFRvIII is accompanied by the co-expression with other members of the HER family and putative cancer stem cell biomarkers CD44 and CD109. The results have shown that co-expression of these biomarkers occurs in patients with glioblastoma. Further investigation should determine whether the co-expression of such biomarkers can be of predictive value for the response to the therapy with various types of HER inhibitors and their potential as therapeutic targets for co-targeted therapy
United Kingdom-European Union policing and law enforcement cooperation in the post-Brexit era
No full textCooperation between European law enforcement agencies has grown reflecting deepening social and economic cooperation between European states. The formal withdrawal of the United Kingdom (UK) from the European Union (EU) (‘Brexit’) generated concerns that the ever-developing structures and processes of cooperation would become fragmented with implications for security. However, few studies have empirically documented the impact of Brexit in its immediate aftermath on policing cooperation. This article starts to fill this empirical gap. Between 2021 and 2023, we drew on a substantial number of interviews with senior, active stakeholders from both police and judicial cooperation in UK and EU areas, in order to critically assess how UK and EU law enforcement personnel have understood the changes brought about by Brexit and worked together in the immediate post-Brexit environment. We find a perception amongst stakeholders that the UK’s departure from the EU was muted over the immediate Brexit period. This was the result of formal contingency planning pre-Brexit, enduring informal relationships between practitioners, and a ‘cushioning’ effect provided by the COVID-19 pandemic travel restrictions. However, we also find complexity. Stakeholders reporting that the implications of Brexit may not be revealed for some time; a perception that the UK had lost influence in decision-making at both the policy and operational level; and that some areas of UK-EU cooperation have been more affected than others (notably in the fields of information exchange and extradition). We consider the implications of these findings
Physiological effects of spirulina supplementation during lactate threshold exercise at simulated altitude (2,500 m) : a randomized controlled trial
No full textDistinctive features of district nursing in contrast to nursing in other settings : a discussion
No full textEffective retention strategies are essential for the sustainability of district nursing services. To develop tailored retention strategies, the authors of this article examine what makes district nursing different compared to hospital and other care settings. Based on literature reviews and discussion groups, the authors identify five key characteristics of district nursing. This article invites expert district nurses to review these characteristics and provide feedback. By clearly identifying the distinctiveness of district nursing, the authors aim to strengthen retention strategies and explore other potential benefits for services