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TAL1 (1p32) deletion in lymphoid malignancies
Full text linkReview on TAL1 deletion in lymphoid malignancies with data on clinics
t(1;19)(q22;p13.2) MEF2D/DAZAP1
Full text linkReview on t(1;19)(q22;p13.2) MEF2D/DAZAP1, with data on the genes involve
EGFR (Epidermal Growth Factor Receptor)
Full text linkERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), and epigen (EPGN) (Singh, 2016). Ligand binding induces the dimerization of EGFR and autophosphorylation followed by a cascade of downstream phosphorylation events (Capuani et al., 2015). EGFR activation plays a key role in cell survival, proliferation, migration and differentiation (Purba, 2017)
EEF1B2 (eukaryotic translation elongation factor 1 beta 2)
Full text linkEukaryotic translation elongation factor 1 beta 2, alias EEF1B2, is a protein-coding gene that plays a role in the elongation step of translation: In fact, it mediates GDP/GTP exchange on eEF1A. Considering its importance it is found frequently overexpressed in human cancer cells. This review collects the data on DNA/RNA, on the protein encoded and on the diseases where EEF1B2 is involved
Psycho-oncology: understanding the processes involved in the experience of users of Complementary or Alternative Medicine (MCA)
No full textObjet : Cet article vise à proposer une définition et une catégorisation des médecines complémentaires et alternatives (MCA). En effet, l’absence de critères précis de définition limite la compréhension de ce mouvement hétérodoxe et des pratiques qui en sont issues. Objectifs : Ce travail répond à un objectif triptyque visant à apporter des repères, à la fois aux usagers, aux professionnels de santé tout en proposant un référentiel commun pour la recherche. Méthode et matériel : L’élaboration de la définition s’est appuyée sur l’analyse de 62 publications francophones issues des sciences médicales et pharmacologiques, des sciences humaines et sociales ainsi que des sciences politiques et juridiques. La mise en œuvre de la catégorisation a reposé sur l’analyse de 9 classifications nationales et internationales. Après avoir synthétisé l’ensemble des corpus, nous avons procédé à une analyse critique permettant de mettre en lumière les lignes de force et les limites des différentes définitions et classifications. Nous avons ensuite répertorié les principaux éléments structurants des MCA permettant de les conceptualiser (définition) et de les délimiter (catégorisation). Résultats : L’analyse des publications apporte des repères théoriques structurants mais pointe la logique de segmentation des approches conceptuelles et le cloisonnement de la pensée qui en découle. L’analyse des classifications montre une tentative utile d’objectivation de ces recours mais révèle la difficulté d’établir une délimitation hermétique des pratiques. Conclusion : La définition et la catégorisation proposées constituent deux outils utiles pour les usagers, les soignants et les chercheurs, contribuant ainsi à la structuration de ce champ.Purpose: This article aims to propose a definition and categorization of complementary and alternative medicine (MCA). Indeed, the absence of precise definition criteria limits the understanding of this heterodox movement and of the practices which have resulted from it. Objectives: Thus, this work responds to a triptych objective aimed at providing benchmarks, both to users, to health professionals while proposing a common reference for research. Method and material: The development of the definition was based on the analysis of 62 French-language publications from the medical and pharmacological sciences, the human and social sciences as well as the political and legal sciences. The implementation of the categorization was based on the analysis of 9 national and international classifications. After having synthesized all the corpora, we proceeded to a critical analysis allowing to highlight the main lines and the limits of the different definitions and classifications. We then listed the main structuring elements of MCA allowing to conceptualize them (definition) and delimit them (classification). Results: The analysis of the publications provides theoretical benchmarks structuring but points to the logic of segmentation of the conceptual approaches and the compartmentalization of the thought which results from it. Analysis of the classifications shows a useful attempt to objectify these remedies but reveals the difficulty of establishing a hermetic delimitation of practices. Conclusion: The proposed definition and classification are two useful tools for users, caregivers and researchers, thus helping to structure this field
Y RNA in cell cycle progression and cancer
Full text linkA growing amount of evidence demonstrates the role of non-coding RNAs (ncRNA) in the etiopathogenesis of cancer. ncRNA are the product of the transcription of genes which are not further translated into proteins, thus they exert their functions as they are or more frequently after post-transcriptional modifications. In the last decades, several different classes of ncRNA had been described, both long (lncRNA) and short (sncRNA). The former are molecules usually longer than 200 nucleotides (nt), while the latter usually include species of a few tens of nucleotides in length, although exceptions are present (for example, circRNA span a length of 100-1600nt; snoRNA are 60-300nt). Y RNA belong to the sncRNA family and are in the range of ca. 80-120nt. Here we summarize the current knowledge about Y RNA biology, their role in normal cellular homeostasis, and their expression variations in human cancers
BUB3 (BUB3 mitotic checkpoint protein)
Full text linkBUB3 is a WD40 protein that belongs to spindle mitotic checkpoint complex, which monitors the chromosome attachment to mitotic (or meiotic) fuse and prevents premature chromosome segregation. Alterations in BUB3 have been associated with chromosomal instability and aneuploidy, but their contribution for cancer development and progression are poorly understood, and appear to differ depending on the type of cancer. The present review contains data on BUB3 DNA, RNA, protein encoded and function