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Cross-Section Measurements for the Production of a W-Boson in Association with High-Transverse Jets in pp Collisions at S = 13 TeV with the ATLAS Detector
No full textA set of measurements for the production of a W-boson in association with high-transverse-momentum jets is presented using 140 fb-1 of proton–proton collision data at a centre-of-mass energy of s=13 TeV collected by the ATLAS detector at the LHC. The measurements are performed in final states in which the W-boson decays into an electron or muon plus a neutrino and is produced in association with jets with pTEMPTY>30 GeV, where the leading jet has pTEMPTY>500 GeV. The angular separation between the lepton and the closest jet with pTEMPTY>100 GeV is measured and used to define a collinear phase space, wherein measurements of kinematic properties of the W-boson and the associated jet are performed. The collinear phase space is populated by dijet events radiating a W-boson and events with a W-boson produced in association with several jets and it serves as an excellent data sample to probe higher-order theoretical predictions. Measured differential distributions are compared with predictions from state-of-the-art next-to-leading order multi-leg merged Monte Carlo event generators and a fixed-order calculation of the W+1-jet process computed at next-to-next-to-leading order in the strong coupling constant. © 2025 Elsevier B.V., All rights reserved
Erratum to: Measurement of T-Channel Production of Single Top Quarks and Antiquarks in pp Collisions at 13 TeV Using the Full ATLAS Run 2 Data Sample (Journal of High Energy Physics, (2024), 2024, 5, (305), 10.1007/jhep05(2024)305)
No full textCombined Use of Essential Oils With Organic Acids in Modifying Performance, Intestinal Health, Caecal Microflora, and Selected Blood and Bone Parameters in Broilers
No full textRamay, Muhammad Shazaib/0000-0002-7061-0483;Essential oils (EOs) and organic acids (OAs) are promising feed additives with crucial roles in promoting animal health and performance. This study aimed to assess the combined effects of phytobiotics with organic acids (EOAs) in broiler diets for 39 days. A total of daily 300 male chicks were assigned to three groups, each containing 100 chicks with 5 replicates. The basal diet was supplemented with 0, 0.1, and 0.2% EOAs, respectively. EOAs supplementation did not significantly affect performance values. The villus height/crypt depth ratio in the jejunum and villus dimensions in the ileum showed improvement with EOAs. Dietary EOAs supplementation led to a reduction in the count of Enterobacteriaceae and an increase in Lactobacillus in the caecum. Serum IgA and IgG levels increased with EOAs. Ultimate load, yield load, and the levels of ash, calcium, phosphorus, zinc, and manganese in tibia and femur were higher at high levels of EOAs than in the other groups. In conclusion, the study suggests that 0.1% EOAs usage in diets could be a viable option for enhancing intestinal health, immunity, and bone mineralization as an alternative growth promoter, especially in commercial broiler production
Mimari Tasarım Sürecinde İletişim Dinamikleri: Disiplinlerarası Öğrenci Atölyesi Deneyimi Üzerine Bir Vaka Çalışması
No full textMimari tasarım süreci farklı paydaşlarla bir arada çalışmayı gerektiren bir süreç olarak karşımıza çıkmaktadır. Modern dünyanın gereklilikleri, teknolojik ve hızlı üretim beklentisi disiplinlerarası çalışma ortamlarını gerekli kılmaktadır. Disiplinler arası iş birliliği, farklı disiplinlerden gelen bireylerin perspektiflerini ve bilgi birikimlerini bir araya getirerek daha kapsamlı ve etkili tasarım çözümleri üretir. Mimarlık eğitiminde disiplinlerarası ortamların yer almasının önemine dikkat çekilmektedir. Ancak literatürde mimarlık eğitiminde disiplinler arası ortamlarla ilgili yapılan çalışmalar incelendiğinde iletişimin önemi ve gerekliliği üzerine durulsa da iletişim dinamiklerini inceleyen çalışmalar konusunda bir boşluk olduğu görülmektedir. Bu sebeple bu çalışma mimarlık eğitimine disiplinlerarası ortamların entegre edilmesi için iletişim dinamiklerini çatışma anları üzerinden inceleyerek literatüre katkı sağlamayı hedeflemektedir. Bu tez, disiplinlerarası ortamlardaki iletişim dinamiklerini incelemek için iki farklı disiplinlerarası öğrenci çalıştayı verilerine odaklanır. Ana hedef, mimarlık öğrencilerinin disiplinlerarası projelerde karşılaşılaşabilecekleri iletişim zorluklarına etkili bir şekilde yaklaşmalarını sağlayan dinamikleri belirlemektir. Bu sebeple öncelikle grup içi etkileşim ve dinamikleri analiz eder. İletişim dinamiklerinin analizi gözlem notları, çalıştay sırasında alınan video kayıtlarının tekrar izlenerek tutulan notlar ve çalıştay sonrası çatışma anları olarak belirlenen bazı kesitlerin katılımcılara izletilerek görüşlerinin alındığı birebir görüşme verilerine dayanır. Tüm süreç içerisindeki çatışma ve çatışma yöntemlerinin, çözüm yaklaşımlarının, bilişsel ve etkileşimsel sebeplere dayandığını öne sürer. Bu çatışma dinamikleri, çözüm stratejileri ve çözülemeyen çatışmaların dinamikleri analiz edilerek gruplandırılır. Bu çalışma, iletişim süreçlerini çatışma anları üzerinden analiz etmeye ve bu çatışmaların çözüm dinamiklerini incelemeye odaklanmaktadır. İletişim dinamiklerinin bütüncül olarak değerlendirilmesi gerektiğini ortaya koymakta ve bu doğrultuda, sözlü ve sözlü olmayan iletişim unsurlarını ortaya çıkarmak amacıyla konuşma analizinden elde edilen analitik araçlardan yararlanılarak çok modlu söylem analizi yöntemi kullanılmaktadır. Bulgular, çatışma yönetiminin çatışmanın doğasına bağlı olarak farklı etkiler yarattığını göstermektedir. Çatışmaların disiplin perspektif farklılıkları, teknik bilgi eksikliği, kişisel farklılıklar gibi bilişsel sebeplerin yanı sıra, söz kesme, sessizlik, aktif dinleme eksikliği, mimikler ve beden dili gibi etkileşimsel sebeplerle, çok katmanlı etkenlerden kaynaklandığını göstermektedir. Bu çatışmalar, kimi zaman öğrenme ve ortak anlam üretimi için bir zemin oluştururken, kimi zaman da çözüm üretilemeyen tıkanmalarla sonuçlanmaktadır. Çatışmaların çözülememesinin sebeplerinin tamamında etkileşimsel sebeplerin olduğunu ortaya koymakta ve iletişim dinamiklerini incelemektedir. İletişim dinamiklerinin kapsamlı analizi, disiplinlerarası ortamlarda ortak anlayışın sağlanabilmesi için sözlü ve sözlü olmayan iletişimi birlikte ele alan bütüncül yaklaşımların gerekliliğini ortaya koymaktadır. Buna göre konuşmalar sırasında sıra almak için bir geçiş yeri arama, çakışmaların yönetilmesindeki iletişim yaklaşımları, sessizlik süresinin yönetilmesi, konuşma sırasına yaklaşımlar, ses tonu gibi sözel iletişim unsurlar ile modelite kullanımları, çatışma anlarındaki jest, mimik ve beden dili yaklaşımları gibi sözlü olmayan iletişimlerin çatışma yönetimlerindeki etkinliği ortaya konmaktadır. Bu doğrultuda, mimarlık öğrencilerinin sözlü ve sözlü olmayan iletişim yetkinliklerinin geliştirilebilmesine yönelik önerilere kısaca yer verilmiştir.The architectural design process is characterized by the necessity of collaboration among diverse stakeholders. The demands of the modern world, coupled with technological advancements and rapid production expectations, require the establishment of interdisciplinary work environments. Such collaboration brings together the perspectives and expertise of individuals from various disciplines, ultimately generating more comprehensive and practical design solutions. The significance of integrating interdisciplinary environments into architectural education is underscored in the existing literature. However, a review of studies related to interdisciplinary settings in architectural education reveals a notable deficiency in research addressing communication dynamics. Consequently, this study aims to fill this gap by examining communication dynamics during the design process, with the goal of enhancing the efficient integration of interdisciplinary environments into architectural education, particularly in conflict situations. This thesis focuses on the data derived from two distinct interdisciplinary student workshops to investigate the communication dynamics within interdisciplinary environments. The primary objective is to identify the dynamics that enable architecture students to effectively navigate the communication challenges they may encounter in interdisciplinary projects. To achieve this, the study first analyzes group interactions and dynamics. The analysis of communication dynamics is informed by observation notes, memos generated from reviewing video recordings taken during the workshops, and data obtained from participant interviews regarding specific conflict instances shown to the participants after the workshops. The findings indicate that conflicts and the methods employed to resolve them are fundamentally rooted in cognitive and interactional factors. The study categorizes these conflict dynamics, solution strategies, and aspects of unresolved conflicts. It emphasizes the importance of a holistic evaluation of communication dynamics, employing the Multimodal Discourse Analysis method informed by analytical tools from Conversation Analysis to elucidate both verbal and non-verbal communication elements. The findings indicate that conflict management yields varying effects depending on the nature of the conflict. Conflicts arise from a multitude of factors, including cognitive aspects such as differing disciplinary perspectives, gaps in technical knowledge, and personal differences, as well as interactional elements like interruptions, silence, lack of active listening, facial expressions, and body language. While these conflicts can sometimes serve as a foundation for learning and the creation of shared meaning, they can also lead to unresolved blockages. The analysis reveals that the reasons behind unresolved conflicts are largely interactional and investigates the dynamics of communication. A thorough examination of these communication dynamics underscores the importance of holistic approaches that integrate both verbal and non-verbal communication to foster mutual understanding in interdisciplinary environments. As such, the effectiveness of various elements of verbal communication—such as seeking a transition relevance place to take the turn during conversations, conflict management approaches of communication, silence management, turn taking, and tone of voice—alongside non-verbal communication elements like modality use, gestures, facial expressions, and body language in moments of conflict, is highlighted. In this context, suggestions for enhancing the verbal and non-verbal communication competencies of architecture students are briefly discussed
The Temporal Dance: How Therapist Presence and Alliance Evolve Across Early Sessions of Psychotherapy
No full textIkizer, Gozde/0000-0003-3567-5991;ObjectiveAlthough there is notable evidence supporting the importance of the therapeutic alliance and therapist presence in psychotherapy practice, the question of how these factors interact dynamically over time remains to be answered. This study investigated how therapists adjust their presence in response to client distress and how this responsive pattern is moderated by therapeutic alliance during the beginning phase of psychotherapy.MethodPre-session symptom measurements and post-session ratings of therapist presence and alliance were collected across the first five consecutive sessions from 46 clients and 22 novice therapists, allowing examination of temporal sequences in therapeutic processes.ResultsTherapists' presence increased in response to higher pre-session symptom levels, with this responsive pattern evolving over time. This relationship was moderated by therapeutic alliance, with stronger alliance providing a context that attenuated the presence-symptom association. Notably, therapist ratings showed stronger predictive relationships with outcomes than client ratings, possibly reflecting the unique observational capacity of therapists in their earliest professional encounters.ConclusionThese findings demonstrated how therapist presence operates as a dynamic, responsive intervention rather than a static therapeutic factor, suggesting that alliance functions as a contextual moderator rather than merely a direct predictor of outcome.The Scientific and Technological Research Council of TurkiyeThe data preparation and analysis process were conducted through interactive consultation with Claude (Anthropic, 2024), a large language model, to enhance methodological rigour and analytical accuracy
Nötrofillerde Endoplazmik Retikulum Stresinin ve Apoptoz Yolaklarının Yineleyen Düzelen Multipl Sklerozda Dimetil Fumarat Tedavisinin Etkinliğinin Değerlendirilmesinde Biyobelirteç Olarak Kullanımının Boylamsal Araştırması
No full textMultiple sclerosis (MS) is an autoimmune, neurodegenerative, and neuroinflammatory disease affecting the central nervous system (CNS) and is usually a cause of non-traumatic disability in young adults aged 20-40 years. Dimethyl fumarate (DMF) is an immunomodulatory drug used as a first-line treatment for the most common relapsing-remitting form of MS (RRMS). While there is no definitive cure for MS, treatments that modify the disease course may not always be effective due to inter-individual differences and the heterogeneous nature of symptoms. In this case, biomarkers that can reflect disease progression at an early stage are needed. Neutrophils are the most common leukocytes in the immune system that can phagocytose, regulate inflammatory molecules, and contribute to the autoimmune nature of MS by presenting antigens. The endoplasmic reticulum (ER) stress seen in neurodegenerative diseases leads to loss of cell homeostasis and apoptosis due to the inability to tolerate the increased protein load. Increased levels of inflammatory molecules regulated by neutrophils and ER stress markers in CNS lesions have been reported in MS. In this thesis, the relative expression levels (REL) of ER stress and apoptosis marker genes and proteins in neutrophils of RRMS patients were analyzed in the context of treatment response. REL values of these genes were calculated from real-time PCR results of RRMS patients admitted to the Neurology Outpatient Clinic of Ankara Bilkent City Hospital before DMF treatment (0A) and in groups formed at the 3rd month (3A) and 6th month (6A) of treatment. Analyses showed a significant increase in BCL2 and CASP3 genes' REL values in the 6A group compared to the 0A group. Changes in protein levels of these genes were also analyzed. Analyses among the 0A, 3A, and 6A groups revealed a significant decrease in expanded disability severity scores (EDSS) and a reduction in the number of T2 lesions in the 3A and 6A groups compared to the 0A group. While a negative correlation was found between the change in BCL2 gene's REL values and the change in EDSS score and T2 lesion number, a positive correlation was found between the changes in REL values of Bcl2 and Caspase-3 proteins and the change in T2 lesion number, and a negative correlation was found between the change in EDSS score. This study highlights the importance of the REL values of BCL2 and CASP3 genes, as well as the significant association of BCL2 gene, Caspase-3 and Bcl2 proteins with clinical parameters. It also suggests the evaluation of apoptosis markers as potential biomarkers reflecting treatment response. Furthermore, this thesis is the first study to examine ER stress and apoptosis marker genes in neutrophils of patients with RRMS in the context of DMF treatment response. It contributes to the field of Biomedical Engineering by providing insights into the for the early determination of treatment efficacy in MS, as well as strategies for the development of biomarkers, diagnostic kits and biosensors.Multipl skleroz (MS), merkezi sinir sistemini (MSS) etkileyen, otoimmün, nörodejeneratif ve nöroenflamatuar bir hastalık olup genellikle 20-40 yaş arası genç yetişkinlerde travma harici engelliliğin bir sebebi olarak görülür. Dimetil fumarat (DMF), MS'nin en sık görülen yineleyen-düzelen formunda (RRMS) birinci basamak tedavi olarak kullanılan immünmodülatör bir ilaçtır. MS'nin kesin bir tedavisi olmamakla birlikte hastalık seyrini değiştiren tedaviler, bireyler arası farklılıklar ve semptomların heterojen doğası nedeniyle her zaman etkili olmayabilir. Bu durumda, hastalık progresyonunu erken dönemde yansıtabilecek biyobelirteçlere ihtiyaç vardır. Nötrofiller, bağışıklık sisteminde fagositoz yapabilen, enflamatuar molekülleri düzenleyen ve antijen sunarak MS'nin otoimmün doğasına katkıda bulunabilen en yaygın lökositlerdir. Nörodejeneratif hastalıklarda görülen endoplazmik retikulum (ER) stresi, artan protein yükünün tolere edilememesi sonucunda hücrede homeostaz kaybına ve apoptoza neden olur. MS'de nötrofiller tarafından düzenlenen enflamatuar molekülllerde ve ayrıca MSS'de görülen lezyonlarda ER stres belirteçlerinde artış bildirilmiştir. Bu tez çalışmasında, RRMS hastalarının nötrofillerinde ER stresi ve apoptoz belirteci genlerin ve proteinlerin rölatif ifade seviyeleri (REL) tedavi yanıtı kapsamında incelenmiştir. Ankara Bilkent Şehir Hastanesi Nöroloji Polikliniğine başvuran RRMS hastalarının DMF tedavisi öncesi (0A) ve tedavinin 3.ayı (3A) ile 6.ayında (6A) oluşturulan gruplarda bu genlerin REL değerleri, gerçek zamanlı PCR sonuçlarından hesaplanmıştır. Analizler, 6A grubunda 0A grubuna kıyasla BCL2 ve CASP3 genlerinin REL değerlerinde anlamlı artış göstermiştir. Ayrıca, bu genlere ait protein düzeylerindeki değişimler de incelenmiştir. 0A, 3A ve 6A grupları arasında yapılan analizlerde, genişletilmiş engellilik durum ölçeği (EDSS) puanında anlamlı bir azalma, T2 lezyon sayılarında ise 3A ve 6A gruplarında 0A grubuna kıyasla düşüş saptanmıştır. BCL2 geninin REL değerindeki değişim ile EDSS puanı ve T2 lezyon sayısı değişimi arasında negatif bir ilişki bulunurken; Bcl2 ve Kaspaz-3 proteinlerin REL değerlerindeki değişimlerle T2 lezyon sayısında görülen değişim arasında pozitif, EDSS puanında görülen değişim arasında negatif bir ilişki belirlenmiştir. Bu çalışma, BCL2 ve CASP3 genlerinin REL değerleri ile BCL2 geni, Kaspaz-3 ve Bcl2 proteinlerinin klinik parametrelerle gösterdiği anlamlı ilişkinin önemine ve apoptoz belirteçlerinin tedavi yanıtını yansıtan potansiyel biyobelirteçler olarak değerlendirilmesine işaret etmektedir. Ayrıca, bu tez çalışması RRMS'li hastaların nötrofillerinde ER stres ve apoptoz belirteci genlerin DMF tedavi yanıtı kapsamında incelendiği ilk çalışma olup, MS'de tedavi etkinliğinin erken dönemde belirlenmesinde biyobelirteç, tanı kiti ve biyosensör geliştirme stratejileri açısından Biyomedikal Mühendisliği alanına katkı sağlamaktadır
Association Between Vertebral Artery Stiffness and Idiopathic Subjective Tinnitus: A Prospective Study
No full textObjectives: Tinnitus, defined as the perception of sound without an external stimulus, is a complex condition with unclear etiology. Emerging evidence suggests a link between vascular dysfunction, particularly arterial stiffness, and tinnitus. This study aimed to evaluate vertebral artery stiffness in patients with idiopathic subjective tinnitus and assess the utility of Doppler ultrasonography as a non-invasive diagnostic tool. Materials and Methods: In this prospective study, 31 patients with idiopathic tinnitus (11 males, 20 females; mean age: 50.42 +/- 9.64 years) and 24 healthy controls (12 males, 12 females; mean age: 39.67 +/- 10.63 years) underwent comprehensive clinical evaluations, including pure tone audiometry, blood tests, and vertebrobasilar Doppler ultrasonography. Vertebral artery stiffness index (VAS), resistive index (RI), and pulsatility index (PI) were measured bilaterally. Results: A total of 31 patients with idiopathic subjective tinnitus and 24 healthy controls were evaluated. The mean age was significantly higher in the tinnitus group compared to controls (50.42 +/- 9.64 vs. 39.67 +/- 10.63 years, p 0.001). Lipid profile analysis revealed significantly higher levels of total cholesterol (193.6 +/- 47.28 vs. 167.5 +/- 28.99 mg/dL, p = 0.021), LDL (149.4 +/- 37.9 vs. 106.1 +/- 10.7 mg/dL, p 0.005), and triglycerides (202.2 +/- 83.5 vs. 148.6 +/- 26.4 mg/dL, p 0.005) in tinnitus patients. Doppler ultrasonography demonstrated significantly higher vertebral artery stiffness values in the tinnitus group (left: 2.87 +/- 0.72 vs. 2.12 +/- 0.22; right: 2.99 +/- 0.77 vs. 2.14 +/- 0.5; both p 0.005). Similarly, pulsatility index (PI) was significantly elevated in patients compared to controls (left: 2.45 +/- 1.2 vs. 1.2 +/- 0.43; right: 2.49 +/- 1.02 vs. 1.19 +/- 0.42; both p 0.005). No significant differences were observed in resistive index (RI) or vertebral artery diameters between groups. Among tinnitus patients, PI and VAS were significantly higher on the side corresponding to reported tinnitus symptoms (p 0.05), suggesting a lateralized vascular contribution. Conclusions: The findings suggested a potential relationship between idiopathic subjective tinnitus and vertebral artery stiffness. We demonstrated the utility of Doppler ultrasonography, a cost-effective and non-invasive imaging modality, for evaluating vascular parameters in tinnitus patients, paving the way for broader clinical applications. By uncovering a significant association between vertebral artery stiffness and tinnitus, our findings suggest that vascular health assessments could enhance diagnostic and therapeutic strategies for tinnitus management
Robust Observer Design for the Longitudinal Dynamics of a Fixed-Wing Aircraft
No full textThis paper presents a novel control-based observer (CbO) framework for robust state and disturbance estimation in the longitudinal dynamics of fixed-wing aircraft. In this approach, the observer design problem is recast as an equivalent control problem, enabling the use of advanced control techniques for observer synthesis. Within the proposed framework, the estimation of both system states and unknown disturbance inputs is achieved by integrating disturbance rejection capabilities into the control sub-block of the observer. This integration ensures that the output mismatch between the plant and observer model is minimized, even in the presence of modeling uncertainties and external disturbances. Two observer designs are developed: (i) an H-infinity-CbO, formulated as an H infinity control problem around a linearized model at a nominal operating point, and (ii) a robust H-infinity-CbO, which extends the design to account for significant model nonlinearities and variations by incorporating multiple operating points and optimizing for the worst-case estimation error. The longitudinal dynamics of a fixed-wing aircraft are derived and linearized to provide the basis for observer design. The performance of the proposed observers is evaluated through comprehensive simulation studies under three scenarios: operation at the nominal point, operation around neighboring points, and comparison with conventional linear observers. Simulation results demonstrate that the proposed observer offers superior robustness and accuracy in estimating both states and external disturbances, particularly in the presence of model uncertainties and varying flight conditions
Building Influence Through Architecture: The British Council’s Film Van in Post-War Turkey
No full textThis article examines a film van constructed by the British Council in the late 1940s, used to screen short documentary films across Anatolia to reach a broader audience. This and other cultural activities organised by the Council, including English language teaching, exhibitions, film screenings, and lectures, were part of Britain’s wider soft power strategy, aimed at fostering good will abroad during and after World War Two. The film van resonates with broader strategies of cultural influence adopted by the British Council beyond Turkey. Through these activities, Britain sought to cultivate a positive image amidst the tense geopolitical climate of the war. Architecture emerged post-war as a medium for cultural exchange between the two nations, serving as a symbol of cultural identity and a tool of soft power. This article shows that exploring architecture’s role in conveying soft power concerns intangible, ephemeral, and mobile dimensions as much as the built environment. © 2025 Elsevier B.V., All rights reserved
Investigation of the Effect of Pulsed Electromagnetic Field Application on PAD2 Gene Expression in PC12 Cells
No full textTUSEB [32133]This work was supported by TUSEB (32133)