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Constraints on Spin-0 Dark Matter Mediators and Invisible Higgs Decays Using Atlas 13 Tev Pp Collision Data With Two Top Quarks and Missing Transverse Momentum in the Final State
No full textThis paper presents a statistical combination of searches targeting final states with two top quarks and invisible particles, characterised by the presence of zero, one or two leptons, at least one jet originating from a b-quark and missing transverse momentum. The analyses are searches for phenomena beyond the Standard Model consistent with the direct production of dark matter in pp collisions at the LHC, using 139 fb - 1 of data collected with the ATLAS detector at a centre-of-mass energy of 13 TeV. The results are interpreted in terms of simplified dark matter models with a spin-0 scalar or pseudoscalar mediator particle. In addition, the results are interpreted in terms of upper limits on the Higgs boson invisible branching ratio, where the Higgs boson is produced according to the Standard Model in association with a pair of top quarks. For scalar (pseudoscalar) dark matter models, with all couplings set to unity, the statistical combination extends the mass range excluded by the best of the individual channels by 50 (25) GeV, excluding mediator masses up to 370 GeV. In addition, the statistical combination improves the expected coupling exclusion reach by 14% (24%), assuming a scalar (pseudoscalar) mediator mass of 10 GeV. An upper limit on the Higgs boson invisible branching ratio of 0.38 (0.30-0.09+0.13) is observed (expected) at 95% confidence level. © 2023, The Author(s).IN2P3-CNRS; SCI/013; National Science Foundation, NSF; U.S. Department of Energy, USDOE; Alexander von Humboldt-Stiftung, AvH; CRC Health Group, CRC: 21/SCI/017; Canarie; H2020 Marie Skłodowska-Curie Actions, MSCA; Multiple Sclerosis Scientific Research Foundation, MSSRF; CERN; Compute Canada; Göran Gustafssons Stiftelser; Natural Sciences and Engineering Research Council of Canada, NSERC; National Research Council Canada, NRC; Canada Foundation for Innovation, CFI; Science and Technology Facilities Council, STFC; Leverhulme Trust; European Research Council, ERC; European Cooperation in Science and Technology, COST; Australian Research Council, ARC; National Stroke Foundation, NSF; Neurosurgical Research Foundation, NRF; Helmholtz-Gemeinschaft, HGF; Minerva Foundation; Deutsche Forschungsgemeinschaft, DFG; Agence Nationale de la Recherche, ANR; Japan Society for the Promotion of Science, KAKEN; Ministry of Education, Culture, Sports, Science and Technology, MEXT; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, SNF; Danmarks Grundforskningsfond, DNRF; Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP; National Natural Science Foundation of China, NSFC; Ministerstvo Školství, Mládeže a Tělovýchovy, MŠMT; Fundação para a Ciência e a Tecnologia, FCT; Bundesministerium für Bildung und Forschung, BMBF; Chinese Academy of Sciences, CAS; Austrian Science Fund, FWF; Generalitat de Catalunya; Ministry of Science and Technology of the People's Republic of China, MOST; Agencia Nacional de Promoción Científica y Tecnológica, ANPCyT; Nederlandse Organisatie voor Wetenschappelijk Onderzoek, NWO; Bundesministerium für Wissenschaft, Forschung und Wirtschaft, BMWFW; Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq; Nella and Leon Benoziyo Center for Neurological Diseases, Weizmann Institute of Science; Israel Science Foundation, ISF; Instituto Nazionale di Fisica Nucleare, INFN; Narodowe Centrum Nauki, NCN; Javna Agencija za Raziskovalno Dejavnost RS, ARRS; Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja, MPNTR; Ministerio de Ciencia e Innovación, MICINN; Centre National pour la Recherche Scientifique et Technique, CNRST; Staatssekretariat für Bildung, Forschung und Innovation, SBFI; Horizon 2020; British Columbia Knowledge Development Fund, BCKDF; European Regional Development Fund, ERDF; Defence Science Institute, DSI; Narodowa Agencja Wymiany Akademickiej, NAWA; Institutul de Fizică Atomică, IFA; Agencia Nacional de Investigación y Desarrollo, ANID; Royal Society of South Australia, RSSA; Irish Rugby Football Union, IRFUWe thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; Minciencias, Colombia; MEYS CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRI, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MEiN, Poland; FCT, Portugal; MNE/IFA, Romania; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZŠ, Slovenia; DSI/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TENMAK, Türkiye; STFC, UK; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada and CRC, Canada; PRIMUS 21/SCI/017 and UNCE SCI/013, Czech Republic; COST, ERC, ERDF, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union; Investissements d’Avenir Labex, Investissements d’Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and MINERVA, Israel; Norwegian Financial Mechanism 2014–2021, Norway; NCN and NAWA, Poland; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Göran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, UK. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (UK) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in Ref. []
Integrated and Differential Fiducial Cross-Section Measurements for the Vector Boson Fusion Production of the Higgs Boson in the Formula Presented Decay Channel at 13 Tev With the Atlas Detector
No full textThe vector-boson production cross section for the Higgs boson decay in the Formula Presented channel is measured as a function of kinematic observables sensitive to the Higgs boson production and decay properties as well as integrated in a fiducial phase space. The analysis is performed using the proton-proton collision data collected by the ATLAS detector in Run 2 of the LHC at Formula Presented center-of-mass energy, corresponding to an integrated luminosity of Formula Presented. The different flavor final state is studied by selecting an electron and a muon originating from a pair of Formula Presented bosons and compatible with the Higgs boson decay. The data are corrected for the effects of detector inefficiency and resolution, and the measurements are compared with different state-of-the-art theoretical predictions. The differential cross sections are used to constrain anomalous interactions described by dimension-six operators in an effective field theory. © 2023 CERN, for the ATLAS Collaboration
Institutional Creation as a Local Governance Response To Syrian Refugees: the Case of Turkish Municipalities
No full textArticle; Early AccessExternal shocks constitute ideal moments for exploring the creation of new institutions as well as changes within existing ones. This paper treats the influx of Syrian refugees into Turkish urban centers as a critical juncture and investigates the changes in the local governance bodies as a result. Based on interviews and focus group discussions with administrative and nongovernmental actors involved in the local response to refugees, we explore the factors that contributed to the emergence of new institutions within municipalities and their institutionalization as bodies able to resist changes of municipal mayors across elections. We investigate how the newly created institutions matter for refugee policy response in looking at various host cities before and after the 2019 local elections. We argue that actual change in the way institutions operate takes place in municipalities (and their respective departments within) that have managed to institutionalize their refugee response through innovative and sustainable policy initiatives that can spill over to areas of policymaking other than refugee response, which invest in building capacity and multilevel partnerships.GIZ (Deutsche Gesellschaft fur Internationale Zusammenarbeit GmbH) Turkey OfficeThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Part of the field research for this article is conducted with funding provided by GIZ (Deutsche Gesellschaft fur Internationale Zusammenarbeit GmbH) Turkey Office
Measurement of Cross Sections for Production of a Z Boson in Association With a Flavor-Inclusive or Doubly B-Tagged Large-Radius Jet in Proton-Proton Collisions at P S=13 Tev With the Atlas Experiment
No full textWe present measurements of cross sections for production of a leptonically decaying Z boson in association with a large-radius jet in 13 TeV proton-proton collisions at the LHC, using 36 fb-1 of data from the ATLAS detector. Integrated and differential cross sections are measured at particle level in both a flavor inclusive and a doubly b-tagged fiducial phase space. The large-radius jet mass and transverse momentum, its kinematic relationship to the Z boson, and the angular separation of b-tagged small-radius track jets within the large-radius jet are measured. This measurement constitutes an important test of perturbative quantum chromodynamics in kinematic and flavor configurations relevant to several Higgs boson and beyond-Standard-Model physics analyses. The results highlight issues with modeling of additional hadronic activity in the flavor-inclusive selection, and a distinction between flavor-number schemes in the b-tagged phase space.Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT), Argentina; Yerevan Physics Institute (YerPhI), Armenia; Australian Research Council (ARC), Australia; Bundesministerium fur Wissenschaft, Forschung und Wirtschaft (BMWFW), Austria; Bundesministerium fur Wissenschaft, Forschung und Wirtschaft (FWF), Austria; Azerbaijan National Academy of Sciences (ANAS), Azerbaijan; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil; Sao Paulo Research Foundation (FAPESP), Brazil; Natural Sciences and Engineering Research Council of Canada (NSERC), Canada; National Research Council Canada, Canada; Canada Foundation for Innovation, Canada; European Organization for Nuclear Research (CERN); Agencia Nacional de Investigacion y Desarrollo (ANID), Chile; Chinese Academy of Sciences (CAS), China; Chinese Ministry of Science and Technology (MOST), China; National Natural Science Foundation of China (NSFC), China; Ministerio de Ciencia, Tecnologia e Innovacion (Minciencias), Colombia; Ministry of Education, Youth, and Sports (MEYS CR), Czech Republic; Danish National Research Foundation (DNRF), Denmark; Danish Natural Science Research Council (DNSRC), Denmark; Institut national de physique nucleaire et de physique des particules, Centre National de la Recherche Scientifique (IN2P3-CNRS), France; Institut de recherche sur les lois fondamentales de l'Univers, Direction des Sciences de la Matiere, Commissariat a` l'Energie Atomique (CEA-DRF/IRFU), France; Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Helmholtz Association (HGF), Germany; Max-Planck-Gesellschaft (MPG), Germany; General Secretariat for Research and Innovation (GSRI), Greece; Research Grants Council (RGC), China; Hong Kong SAR, China; Israel Science Foundation (ISF), Israel; Benoziyo Center, Israel; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan; Japan Society for the Promotion of Science (JSPS), Japan; National Centre for Scientific and Technical Research (CNRST), Morocco; Netherlands Organisation for Scientific Research (NWO), Netherlands; Research Council of Norway (RCN), Norway; Ministry of Education and Science (MEiN), Poland; Foundation for Science and Technology (FCT), Portugal; Ministry of National Education, Institute of Atomic Physics (MNE/IFA), Romania; Ministry of Education, Science and Technological Development (MESTD), Serbia; Ministry of Education, Science, Research and Sport (MSSR), Slovakia; Slovenian Research Agency (ARRS), Slovenia; Ministry of Education, Science and Sport (MIZS), Slovenia; Department of Science and Innovation (DSI/NRF), South Africa; Ministry of Science and Innovation (MICINN), Spain; Swedish Research Council (SRC), Sweden; Wallenberg Foundation, Sweden; Secretariat for Education and Research (SERI), Switzerland; Swiss National Science Foundation (SNSF), Switzerland; Canton of Bern, Switzerland; Canton of Geneva, Switzerland; Ministry of Science and Technology (MOST), Taiwan; Turkish Energy, Nuclear and Mineral Research Agency (TENMAK), Tuerkiye; Science and Technology Facilities Council (STFC), United Kingdom; U.S. Department of Energy (DOE), United States of America; National Science Foundation (NSF), United States of America; British Columbia Knowledge Development Fund (BCKDF), Canada; Canada's Advanced Research and Innovation Network (CANARIE), Canada; Compute Canada, Canada; CRC, Canada; PRIMUS Research Programme (PRIMUS), Czech Republic; University Research Center (UNCE), Czech Republic; COST, European Union; ERC, European Union; European Regional Development Fund (ERDF), European Union; Horizon 2020, European Union; Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex), France; Investissements d'Avenir Idex), France; Agence Nationale de la Recherche (ANR)), France; Deutsche Forschungsgemeinschaft (DFG) , Germany; Alexander von Humboldt Foundation (AvH), Germany; EU-ESF, Greece; Greek NSRF, Greece; United States-Israel Binational Science Foundation (BSF-NSF), Israel; MINERVA, Israel; Norwegian Financial Mechanism 2014-2021, Norway; Polish National Science Centre (NCN), Poland; Polish National Agency for Academic Exchange (NAWA), Poland; La Caixa Banking Foundation, Spain; CERCA Programme Generalitat de Catalunya, Spain; Generalitat Valenciana, Spain; Goeran Gustafssons Stiftelse, Sweden; Royal Society , United Kingdom; Leverhulme Trust, United Kingdom; [21/SCI/017]; [SCI/013]We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT), Argentina; Yerevan Physics Institute (YerPhI), Armenia; Australian Research Council (ARC), Australia; Bundesministerium fuer Wissenschaft, Forschung und Wirtschaft (BMWFW) and Bundesministerium fuer Wissenschaft, Forschung und Wirtschaft (FWF), Austria; Azerbaijan National Academy of Sciences (ANAS), Azerbaijan; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Sao Paulo Research Foundation (FAPESP), Brazil; Natural Sciences and Engineering Research Council of Canada (NSERC), National Research Council Canada and Canada Foundation for Innovation, Canada; European Organization for Nuclear Research (CERN); Agencia Nacional de Investigacion y Desarrollo (ANID), Chile; Chinese Academy of Sciences (CAS), Chinese Ministry of Science and Technology (MOST) and National Natural Science Foundation of China (NSFC), China; Ministerio de Ciencia, Tecnologia e Innovacion (Minciencias), Colombia; Ministry of Education, Youth, and Sports (MEYS CR), Czech Republic; Danish National Research Foundation (DNRF) and Danish Natural Science Research Council (DNSRC), Denmark; Institut national de physique nucleaire et de physique des partic-ules, Centre National de la Recherche Scientifique (IN2P3-CNRS) and Institut de recherche sur les lois fondamentales de l'Univers, Direction des Sciences de la Matiere, Commissariat a` l'Energie Atomique (CEA-DRF/IRFU), France; Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia; Bundesministerium fuer Bildung und Forschung (BMBF), Helmholtz Association (HGF) and Max-Planck-Gesellschaft (MPG), Germany; General Secretariat for Research and Innovation (GSRI), Greece; Research Grants Council (RGC) and Hong Kong SAR, China; Israel Science Foundation (ISF) and Benoziyo Center, Israel; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Society for the Promotion of Science (JSPS), Japan; National Centre for Scientific and Technical Research (CNRST), Morocco; Netherlands Organisation for Scientific Research (NWO), Netherlands; Research Council of Norway (RCN), Norway; Ministry of Education and Science (MEiN), Poland; Foundation for Science and Technology (FCT), Portugal; Ministry of National Education, Institute of Atomic Physics (MNE/IFA), Romania; Ministry of Education, Science and Technological Development (MESTD), Serbia; Ministry of Education, Science, Research and Sport (MSSR), Slovakia; Slovenian Research Agency (ARRS) and Ministry of Education, Science and Sport (MIZS), Slovenia; Department of Science and Innovation (DSI/NRF), South Africa; Ministry of Science and Innovation (MICINN), Spain; Swedish Research Council (SRC) and Wallenberg Foundation, Sweden; Secretariat for Education and Research (SERI), Swiss National Science Foundation (SNSF) and Cantons of Bern and Geneva, Switzerland; Ministry of Science and Technology (MOST), Taiwan; Turkish Energy, Nuclear and Mineral Research Agency (TENMAK), Tuerkiye; Science and Technology Facilities Council (STFC), United Kingdom; U.S. Department of Energy (DOE) and National Science Foundation (NSF), United States of America.; r In addition, individual groups and members have received support from British Columbia Knowledge Development Fund (BCKDF), Canada's Advanced Research and Innovation Network (CANARIE), Compute Canada and CRC, Canada; PRIMUS Research Programme (PRIMUS) 21/SCI/017 and The University Research Center (UNCE) SCI/013, Czech Republic; COST, ERC, European Regional Development Fund (ERDF), Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and Agence Nationale de la Recherche (ANR), France; Deutsche Forschungsgemeinschaft (DFG) and Alexander von Humboldt Foundation (AvH), Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; United States-Israel Binational Science Foundation (BSF-NSF) and MINERVA, Israel; Norwegian Financial Mechanism 2014-2021, Norway; Polish National Science Centre (NCN) and Polish National Agency for Academic Exchange (NAWA), Poland; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goeran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (United Kingdom) and BNL (USA), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in Ref. [96]
Statistical-Machine Intelligent Relaxation for Set-Covering Location Models To Identify Locations of Charging Stations for Electric Vehicles
No full textEurope strengthens its policies on climate change, green transition, and sustainable energy by addressing the high greenhouse-gas emissions in the transportation sector. Europe aims to reduce such emissions and reach a state of carbon neutrality by 2030 and 2050, respectively. This is feasible only if electric vehicles dominate the transportation sector. Paving the way for electric vehicle deployment on roads is subject to the provision of electric-vehicle-charging stations on the roads such that sufficiently good driving experience without any obstacles can be achieved. To address this timely societal challenge, we proposed a novel methodology by using the well-known facility-location-allocation methodology named set-covering location models with statistical machine learning and developed it for the problem settings of identifying electric-vehicle-charging station locations. Statistical machine learning was employed in the proposed model to more precisely identify and determine feasible coverage sets. We demonstrated the efficiency of the proposed model for the Capital Region of Denmark, where the green transition is part of the political agenda and is of severe societal concern, by using the newly collected main road transportation dataset
Effects of Turbulence and Flamelet Combustion Modelling on the Cfd Simulation of a Dual Inlet Ramjet Combustor
No full textArticle; Early AccessThis manuscript presents Computational Fluid Dynamics simulation of a ramjet combustor using Reynolds Averaged Navier-Stokes approach for turbulence with flamelet combustion modelling. In the approach a one-dimensional premixed flame simulation is performed to cover a wide range of mixture fraction space. After a mesh study, effects of turbulence, Realizable k-e and SST k-?, and combustion modelling, Steady Laminar Flamelet and Flamelet Generated Manifold, are investigated in detail. The Flamelet Generated Manifold model that offers a reaction delay by employing an additional progress variable, shows there are no reactions taking place in the vicinity of jet inlets, hence the unrealistic temperature rise that is seen in the case of using Steady Laminar Flamelet is not observed. A study on the choice of progress variable based on the combustion products is carried out. The present study readily demonstrates good predictability of Flamelet Generated Manifold combustion modelling in such a dual inlet ramjet combustion chamber
Kadına Yönelik Şiddet: Şiddetin Nedeni, Onur Benimseme Düzeyi Ve Düşmanca Cinsiyetçiliğin Rolü
No full textEge 9. Uluslararası Sosyal Bilimler Kongrei / Ege 9th International Conference on Social SciencesBu çalışma temel olarak, kadına yönelik şiddet konusunu ele almaktadır. Çalışmanın amacı (1) partner şiddetine yönelik tutumlarda, şiddetin nedeninin rolünü ve (2) düşmanca cinsiyetçiliğin, onuru benimseme düzeyi ile partner şiddetine yönelik tutumlar arasındaki ilişkideki düzenleyici rolünü incelemektir. Bu amaçla, evli bir çift arasındaki çatışmaları tasvir eden dört farklı senaryo oluşturulmuştur. Senaryolardan birinde (onur koşulu), bir erkek eşinin onu aldattığını öğrenmektedir. Diğer senaryoda ise (finansal çatışma koşulu) eşinin aşırı harcamalarından memnuniyetsizlik duymaktadır. Senaryoların yarısında, erkeğin eşine yönelik şiddeti fiziksel saldırı içermekte, diğer yarısında cinayetle sonuçlanmaktadır. Katılımcılar bu 4 koşuldan birine seçkisiz olarak atanmışlardır. Çalışmaya toplam 241 (137 kadın, 104 erkek, Ort.yaş = 21.81) üniversite öğrencisi katılmıştır. Sonuçlar, şiddetin nedeninin aldatma olduğu ve fiziksel şiddet uygulandığı koşulun; şiddete yönelik daha olumlu tutumlar, şiddet gösteren kişiye daha yakınlık duyma, şiddet gösteren kişinin karakterini daha olumlu belirtme ve eşini daha çok sevdiği algısı ile ilişkili olduğunu göstermiştir. Ayrıca, onuru benimseme düzeyi ve partner şiddetine yönelik olumlu tutumlar arasındaki ilişkinin, düşmanca cinsiyetçiliğin yüksek olduğu kişilerde daha güçlü olduğu ortaya çıkmıştır.
The Effects of Transcranial Focused Ultrasound Stimulation of Nucleus Accumbens on Neuronal Gene Expression and Brain Tissue in High Alcohol-Preferring Rats
No full textWe investigated the effect of low-intensity focused ultrasound (LIFU) on gene expression related to alcohol dependence and histological effects on brain tissue. We also aimed at determining the miRNA-mRNA relationship and their pathways in alcohol dependence-induced expression changes after focused ultrasound therapy. We designed a case-control study for 100 days of observation to investigate differences in gene expression in the short-term stimulation group (STS) and long-term stimulation group (LTS) compared with the control sham group (SG). The study was performed in our Experimental Research Laboratory. 24 male high alcohol-preferring rats 63 to 79 days old, weighing 270 to 300 g, were included in the experiment. LTS received 50-day LIFU and STS received 10-day LIFU and 40-day sham stimulation, while the SG received 50-day sham stimulation. In miRNA expression analysis, it was found that LIFU caused gene expression differences in NAc. Significant differences were found between the groups for gene expression. Compared to the SG, the expression of 454 genes in the NAc region was changed in the STS while the expression of 382 genes was changed in the LTS. In the LTS, the expression of 32 genes was changed in total compared to STS. Our data suggest that LIFU targeted on NAc may assist in the treatment of alcohol dependence, especially in the long term possibly through altering gene expression. Our immunohistochemical studies verified that LIFU does not cause any tissue damage. These findings may lead to new studies in investigating the efficacy of LIFU for the treatment of alcohol dependence and also for other psychiatric disorders.Scientific and Technological Research Council of Turkey (TUBITAK) [214S249]This research is funded by a grant from the Scientific and Technological Research Council of Turkey (TUBITAK), Grant No. 214S249
Savunma Hakki Baglaminda 5271 Sayili Ceza Muhakemesi Kanununda Basit Yargilama Usulü
No full textCeza Muhakemesi sistemine 7188 sayılı Kanun'la eklenen basit yargılama usulü, CMK'nın 251 ve 252. maddeleri yeniden düzenlenmek suretiyle ceza muhakemesi sistemimize getirilmiştir. Görece basit nitelikte kabul edilen suçlarda duruşma yapılmaksızın hüküm vermeye olanak sağlayan bu usul, mülga 1412 sayılı CMUK'ta düzenlenen sulh ceza hâkiminin ceza kararnamesine son derece benzemektedir. Bu çalışmada, kovuşturma evresine özgü, klasik kovuşturmaya alternatif ve ancak mahkemenin takdiriyle uygulanan bu usul öncelikle; hukuki niteliği, amacı, tarihsel gelişimi, uygulanma şartları, uygulanamayacak haller, verilecek karar, karar karşı başvurulabilecek hukuki çareler bakımından incelenecektir. Ardından, basit yargılama usulünün uygulanması ile savunma hakkının kullanılması arasındaki ilişkiye değinilecek, son olarak savunma hakkı ihlali oluşturabilecek durumlar ortaya konulduktan sonra çözüm önerileri ortaya konulacaktır.The simplified proceeing, hich was brought to the Criminal Procedure system with the Law No. 7188, was brought to our criminal procedure system by rearranging articles 251 and 252 of Criminal Procedure Code. This procedure, which can be adjudicated without a hearing in crimes that are considered to be summary off encesnature, is very similar to the penal decree of the criminal judge of peace, which was issued in there pealed CMUK numbered 1412. In this study, first of all, this procedure, which is specific to the prosecution phase, and an alternative to the classical prosecution, is only applied at the discretion of the court; legal nature, purpose, historical development, application conditions, unenforceable situations, the decision to be made, the decision will be examined in terms of legal remedies that can be applied against. Then, the relationship between the application of the simplified proceeing and the use of the right of defense will be mentioned, and last, the situations that may constitute a violation of the right to defense, solutions will be put forward
Dram Bender: an Extensible and Versatile Fpga-Based Infrastructure To Easily Test State-Of Dram Chips
No full textTo understand and improve DRAM performance, reliability, security, and energy efficiency, prior works study characteristics of commodity DRAM chips. Unfortunately, stateof-the-art open source infrastructures capable of conducting such studies are obsolete, poorly supported, or difficult to use, or their inflexibility limits the types of studies they can conduct. We propose DRAM Bender, a new FPGA-based infrastructure that enables experimental studies on state-of-the-art DRAM chips. DRAM Bender offers three key features at the same time. First, DRAM Bender enables directly interfacing with a DRAM chip through its low-level interface. This allows users to issue DRAM commands in arbitrary order and with finer-grained time intervals compared to other open source infrastructures. Second, DRAM Bender exposes easy-to-use C++ and Python programming interfaces, allowing users to quickly and easily develop different types of DRAM experiments. Third, DRAM Bender is easily extensible. The modular design of DRAM Bender allows extending it to (i) support existing and emerging DRAM interfaces, and (ii) run on new commercial or custom FPGA boards with little effort. To demonstrate that DRAM Bender is a versatile infrastructure, we conduct three case studies, two of which lead to new observations about the DRAM RowHammer vulnerability. In particular, we show that data patterns supported by DRAM Bender uncover a larger set of bit-flips on a victim row than those commonly used by prior work. We demonstrate the extensibility of DRAM Bender by implementing it on five different FPGAs with DDR4 and DDR3 support. DRAM Bender is freely and openly available at https://github.com/CMU-SAFARI/DRAM-B ender. IEE