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Neuroprotective Effects of Milrinone on Acute Traumatic Brain Injury
No full textBACKGROUND: Traumatic brain injury is still an important health problem worldwide. Traumatic brain injury not only causes direct mechanical damage to the brain but also induces biochemical changes that lead to secondary nerve cell loss. In this study, we investigated the neuroprotective effect of milrinone after traumatic brain injury (TBI) in a rat model. METHODS: Forty male Wistar albino rats, were used. Rats were divided into 4 groups: 1) sham, 2) TBI, 3) TBI + Ringers, and 4) TBI + Milrinone. In group 1 (sham), only craniotomy was performed. In group 2 (TBI), TBI was performed after craniotomy. In group 3 (TBI + Ringer), TBI was performed after craniotomy and intraperitoneal Ringers solution was given immediately afterward. Group 4 (TBI + Milrinone), TBI was performed after craniotomy, and milrinone was given 1.0 mg/kg milrinone intraperito-neally directly (0.5 mg/kg milrinone intraperitoneally again 24 hours, 48 hours, and 72 hours after trauma). Tests were performed for neurological and neurobehavioral functions. Immunohistochemistry and histopathology studies were performed. RESULTS: In group 4 compared with group 2 and group 3 groups, tests for neurological functions and neuro-behavioral functions were significantly better. In the mil-rinone treatment used in group 4, plasma and brain tissue tumor necrosis factor, 8-OH 2-deoxyguanosine , and inter-leukin 6 levels were significantly decreased, and increased plasma and tissue IL-10 levels were detected. Histopathological spinal cord injury and apoptotic index increased in groups 2 and 3, while significantly decreasing in group 4. CONCLUSIONS: This study shows for the first time that the anti-inflammatory, antioxidant and antiapoptotic prop-erties of milrinone may be neuroprotective after TBI
Parametric Near-Field Channel Estimation for Extremely Large Aperture Arrays
No full text57th Asilomar Conference on Signals, Systems and Computers, ACSSC 2023 -- 29 October 2023 through 1 November 2023 - 198545Accurate channel estimation is critical to fully ex-ploit the beamforming gains when communicating with extremely large aperture arrays. The propagation distances between the user and receiver, which potentially has thousands of anten-nas/elements, are such that they are located in the radiative near-field region of each other when considering the Fraunhofer distance of the entire array. Therefore, it is imperative to consider near-field effects to achieve proper channel estimation. This paper proposes a parametric multi-user near-field channel estimation algorithm based on MUltiple SIgnal Classification (MUSIC) method to obtain the essential parameters describing the users' locations. We derive the estimated channel by incorporating the estimated parameters into the near-field channel model. Additionally, we implement a least-squares-based estimation corrector, resulting in a precise near-field channel estimation. Simulation results demonstrate that our proposed scheme outperforms classical least-squares and minimum mean-square error channel estimation methods in terms of normalized beamforming gain and normalized mean-square error. © 2023 IEEE.Vetenskapsrådet, V
Eğitimde Blok Zincir Teknolojisinin Araştırılması ve Sürdürülebilir Tasarım Eğitimi için “kayıt Zinciri” Modellerinin Geliştirilmesi
No full text[No Abstract Available
Hemodynamic Effects of Intraluminal Thrombus Burden in an Idealized Abdominal Aortic Aneurysm
No full textAbdominal aortic aneurysm (AAA) is the dilatation of the abdominal aorta beyond 50% of its normal diameter and affects a wide range of society. If left untreated, AAA continues to grow and has a risk of rupture. The AAA rupture is an emergency condition and most of ruptured cases result in death. Understanding the AAA hemodynamics plays an important role for the accurate diagnosis and treatment methods. At this point, computational fluid dynamics (CFD) provide valuable information by simulating the flow in a virtual environment. In this study, AAA hemodynamics are investigated using CFD simulations by focusing on the effect of intraluminal thrombus (ILT) burden in an idealized AAA model. Different levels of ILT burden are virtually implemented in the AAA model, and the hemodynamic differences are analyzed by comparing the shear-related parameters such as wall shear stress (WSS), time-averaged WSS, oscillatory shear index, and endothelial cell activation potential. According to the results, the formation of ILT significantly changes the biomechanical environment in AAA. In the models with low ILT burden, a spatially heterogeneous WSS distribution is observed around the aneurysm. As the ILT burden increases, a relatively smooth and homogenous WSS distribution is obtained on the AAA wall. This shows that ILT acts as a mechanism which prevents the abnormal shear stresses around the aneurysmal enlargement.TUBITAK (The Scientific and Technological Research Council of Tuerkiye) 3501-Career Development Program [221M001]This study is funded by TUBITAK (The Scientific and Technological Research Council of Tuerkiye) 3501-Career Development Program (Project number: 221M001)
Ultracompact Tapers & Splitter for Fishbone-Like Grating Waveguides
No full text13th International Conference on Metamaterials, Photonic Crystals and Plasmonics, META 2023 -- 18 July 2023 through 21 July 2023 -- 300609The use of fishbone-like grating waveguides (FLGWs) in photonic integrated circuits (PICs) presents a challenge in terms of chip space utilization because it requires incorporating conventional, large components. Therefore, we propose the combination of three key elements - a long adiabatic waveguide taper, a power splitter, and a transition region for FLGWs - using digital metamaterials to allow for the effective utilization of FLGWs that are excited by ultrashort pulses in a compact footprint of only 5 × 14.1 μm2. © 2023, META Conference. All rights reserved.Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 119E501, BIDEB 2210
Search for Long-Lived, Massive Particles in Events With Displaced Vertices and Multiple Jets in Pp Collisions at √s=13 Tev With the Atlas Detector
No full textA search for long-lived particles decaying into hadrons is presented. The analysis uses 139 fb(-1) of pp collision data collected at root s = 13TeV by the ATLAS detector at the LHC using events that contain multiple energetic jets and a displaced vertex. The search employs dedicated reconstruction techniques that significantly increase the sensitivity to longlived particles decaying in the ATLAS inner detector. Background estimates for Standard Model processes and instrumental effects are extracted from data. The observed event yields are compatible with those expected from background processes. The results are used to set limits at 95% confidence level on model-independent cross sections for processes beyond the Standard Model, and on scenarios with pair-production of supersymmetric particles with long-lived electroweakinos that decay via a small R-parity-violating coupling. The pair-production of electroweakinos with masses below 1.5TeV is excluded for mean proper lifetimes in the range from 0.03 ns to 1 ns. When produced in the decay of m((g) over tilde) - 2.4TeV gluinos, electroweakinos with m((X) over tilde (0)(1)) = 1.5TeV are excluded with lifetimes in the range of 0.02 ns to 4 ns.ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW; FWF, Austria; ANAS; CNPq; FAPESP, Brazil; NSERC; CFI, Canada; NSFC, China; MEYS CR, Czech Republic; DNRF; DNSRC, Denmark; IN2P3-CNRS; CEA-DRF/IRFU, France; BMBF; MPG, Germany; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT; JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MEiN, Poland; FCT, Portugal; MNE/IFA, Romania; MESTD, Serbia; MSSR, Slovakia; ARRS; MIZS, Slovenia; MICINN, Spain; Wallenberg Foundation, Sweden; SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; DOE; NSF, United States of America; BCKDF; CANARIE; CRC, Canada [PRIMUS 21/SCI/017, UNCE SCI/013]; Czech Republic; ERC; ERDF; Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex; ANR, France; DFG; AvH Foundation, Germany - EU-ESF; Greek NSRF, Greece; BSF-NSF; NCN; La Caixa Banking Foundation; CERCA Programme Generalitat de Catalunya; PROMETEO; Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; Royal Society; Leverhulme Trust, United Kingdom; NDGF (Denmark, Norway, Sweden); KIT/GridKA (Germany); INFN-CNAF (Italy); NL-T1 (Netherlands), PIC (Spain); ASGC (Taiwan); BNL (U.S.A.)We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; Minciencias, Colombia; MEYS CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRI, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MEiN, Poland; FCT, Portugal; MNE/IFA, Romania; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DSI/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TENMAK, Turkiye; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada and CRC, Canada; PRIMUS 21/SCI/017 and UNCE SCI/013, Czech Republic; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and MINERVA, Israel; Norwegian Financial Mechanism 2014-2021, Norway; NCN and NAWA, Poland; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom.; The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF (Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and BNL (U.S.A.), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in ref. [76]
Modernite, Terbiye ve Bellek: Erken Cumhuriyet Dönemi Başkent Ankara’da Tiyatro Sahnesi
No full textCumhuriyet’in erken yıllarında Ankara, Türk modernleşmesinin düşünsel ve yönetsel mekânı olarak; gelecekçi ideolojinin projelendirildiği, yeni ülke idealleri ile yaşama biçiminin konumlandığı, hayatın her alanına dair reformların gerçekleştiği bir laboratuvara dönüşmüştür. Mustafa Kemal Atatürk’ün, çağdaş bir toplumun, kültürel gelişmeler çerçevesinde inşa edilebileceği görüşü, sanatın evrenselliğinden ve eğiticiliğinden yararlanma anlayışı ile görsel temsiller, ulusal topluluk bağlarının güçlenmesinde, yeni belleğin kodlarının aktarılmasında kilit unsurlar olarak görülmüşlerdir. Ankara’nın modern başkente dönüşme serüveni; değişimlerin/dönüşümlerin yaşandığı, modern yaşam pratiklerinin gündelik hayata entegre edildiği ve tüketildiği bir süreci işaret etmektedir. Cumhuriyet liderleri ile memur kesimin deneyimleyerek, Ankara halkına örneklediği ve özendirdiği; tiyatro, konser, sergi gibi etkinliklerin içerdiği mesajların/kodların, tüm Anadolu coğrafyasına yayılması beklenmiş, ortaya çıkacak çağdaş ve modern Türk toplumu, inkılabın kalıcılığını sağlayacak biricik güç olarak tanımlanmıştır. Bu makalede, 1923- 1950 yılları arasında başkentte takip edilen tiyatro etkinliklerine odaklanılmış, Ankara Devlet Konservatuvarı ve Tatbikat Sahnesi’nin kültür ve sanat ortamına katkısı ile Devlet Tiyatro ve Operası kuruluşuna dikkat çekilmiştir. Ankara’da takip edilen tiyatro etkinliklerinin nasıl bir zeminde gelişim gösterdiği, tiyatro sahnesinin devinimi ve dinamikleri ile nasıl kurumsallaştığı ele alınmıştır. Sahnenin kent ve kentli ile kurduğu ilişki, dönemin yayın organları ve Ankara Halkevi dokümanları aracılığıyla, tiyatro sahnesinin kurumsallaşmasının ardından ise Ankara Devlet Konservatuvarı; Devlet Tiyatroları Arşivi, Devlet Tiyatroları Refik Ahmet Sevengil Tiyatro Kütüphanesi, Koç Üniversitesi Vehbi Koç Ankara Araştırmaları Uygulama ve Araştırma Merkezi (VEKAM) Arşivi verileriyle T.C. Cumhurbaşkanlığı Devlet Arşivleri ve TBMM tutanakları taranarak araştırılmış, tespit edilen belgeler ışığında, Erken Cumhuriyet Dönemi’nde başkent Ankara’da kültür ve sanat ortamının en önemli aktörlerinden, tiyatro sahnesi üzerine genel bir tablo oluşturulmaya çalışılmıştır
Management and Organizational Studies on Blue & Grey Collar Workers: Diversity of Collars
No full textThe digital transformation of work during the COVID-19 pandemic seemed in many ways a fair treaty between employers and employees. However, realistically, its advantages have primarily benefitted white-collar workers with the ability to work from home, excluding a significant proportion of the global workforce, those responsible for providing fresh water, environmental hygiene, transportation, electricity, healthcare and food and security services, who do not have the option of conducting their jobs remotely. The pandemic has thus deepened the gap between white and blue and grey collar workers. Combining both theoretical and empirical studies, Management and Organizational Studies on Blue and Grey Collar Workers focuses on recent issues such as digitalization and migration and their implications for organizational commitment, HRM functions and strategic management processes. Acting as an examination of the changing nature of power between blue and grey collar workers and institutional hierarchies in the light of the COVID-19 pandemic, contributors foreground the importance of these roles as a cornerstone for the competitive power of industries and nations, as well as basic global infrastructure, both now and in future. Highlighting the workers who provide the essential services, maintenance and manufactured goods that power the global economy, Management and Organizational Studies on Blue and Grey Collar Workers supplies essential knowledge on an often overlooked workforce for a variety of disciplines, including human resource management, industrial relations, social psychology, labor economics, gender studies, political science, union studies and health care management
Dekübit Ülserlerinin Tedavisinde Larva Tedavisi
No full textDekübit veya bası ülserleri yumuşak dokunun üzerinde bulunduğu kemik ile sert bir dış yüzey arasında sıkışması sonucu oluşan doku nekrozudur. Bası ülseri tedavisinde öncelikle yara üzerindeki baskının azaltılması, nekroze alanların debridmanının yapılması, yaradaki bakteri kolonizasyonunun azaltılması amaçlanmaktadır. Genellikle bu amaçla keskin, mekanik, enzimatik, otolitik ve biyolojik debridman yöntemleri uygulanmaktadır. Larva Tedavisi (LT)’nin ana kullanım amacı da biyolojik debridmandır. Ancak larva salgı ve çıkartılarının dezenfeksiyon, granülasyon, anjiogenezis ve oksijenizasyon ile yara iyileşmesinde de etkili olduğu gösterilmiştir. Diğer debridman yöntemlerine kıyasla LT basınç ülserleri dahil, yarayı daha hızlı temizler, kan damarları ve tendonlar dahil olmak üzere sağlıklı dokuya zarar vermeden, nekrotik dokunun seçici debridmanını yapar, granülasyon ve yaranın iyileşmesini arttırır. Larva tedavisi yatarak veya ayaktan gelen hastaların tedavisine uygun maliyet etkin bir yöntemdir.Decubitus or pressure ulcers are tissue necrosis caused by the compression of the soft tissue between the bone on which it is located and a hard outer surface. In the treatment of pressure ulcers, it is primarily aimed to reduce the pressure on the wound, debride the necrotic areas, and reduce bacterial colonization inside the wound. In general, sharp, mechanical, enzymatic, autolytic and biological debridement methods are being used for this purpose. Larval therapy (LT) is first of all a biological debridement modality, however, larval secretions and exudates have also been shown to be effective in wound healing due to disinfection, granulation, angiogenesis and oxygenation. Compared to other debridement methods, LT cleans the wound faster, do not damage healthy tissue such as blood vessels and tendons, while selectively debrides necrotic tissue, increases granulation and wound healing. It could be used for hospitalized and ambulatory patients and it is a costeffective treatment modality
The Still Enlightened Late-Comers: a Comparison Between the Proto-Modernist Nationalisms of Guiseppe Mazzini and Ziya Gokalp
No full textArticle; Early AccessIn contrast with the distorted and romanticized images reproduced by far-right narratives, we argue in this study that the constructive ideals of nation held by Italy's Giuseppe Mazzini and Turkey's Ziya Gokalp, from two later examples of European nationalism, could fit into what might be called a proto-modernism within nationalism theories. It is proposed that both Mazzini and Gokalp went through ideological transformations that made them firm opponents of German Romanticism and ardent believers of the Enlightenment, as shown in their non-exclusionary approaches to nationalism. They both rejected essentialist (religious, ethnic, racial, etc.) rationales for the backwardness of their respective countries and maintained the necessity of constructing nations that would initially provide civic equality among citizens and then aim at normative equality among nations at the civilizational level. In that sense, our analysis finds four fundamental similarities between Mazzini and Gifikalp with regard to their national ideals: loyalty to the principles of the Enlightenment, national self-determination, civic-legal equality among citizens, and normative equality among all nations.Hakan Ovunc Ongur acknowledges the valuable contributions of the scholars at the Scuola Normale Superiore, Italy, and the research grant by the International Postdoctoral Research Scholarship Programme (BIDEB-2219), Scientific and Technical Research Council of Turkey (TUBITAK) that made this scholarly connection possible.International Postdoctoral Research Scholarship Programme (BIDEB-2219), Scientific and Technical Research Council of Turkey (TUBITAK