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Empirical Hillslope length distributions and hyperbolic model
Full text linkThis deposit contains data (in a folder named Catchments) and codes (MATLAB .m scripts) to properly analyze the data. The file Code_ReadMe.pdf provides some useful insights on how to run the codes and on the outputs produced by them. The data consists in DTMs, drainage and contributing area maps for various catchments
Meso–Cenozoic geodynamic evolution of the Patagonian foreland: insights from low-temperature thermochronology in the Deseado Massif
Full text linkThermal modelling input data and results on Meso–Cenozoic geodynamic evolution of the Patagonian forelan
Computer code for analysis of mixed-oscillations in cortical neurons
No full textXPPAUT and MATLAB files used in the work "Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels" by Matteo Martin and Morten G Pedersen (PLoS Computational Biology, 2024
Ergonomic Design of Human-Robot Collaborative Workstation in the Era of Industry 5.0
No full textThe increasing adoption of collaborative robots to support job execution in manufacturing has catalyzed companies' attention to safety and well-being issues. Sharing the human-centric perspective and harmonious human-machine collaboration concepts emphasized by Industry 5.0, the design phase of a collaborative workstation must integrate both psychological and physical risk evaluations to provide a safe and inclusive work environment suitable for a diversified workforce. Accelerating the pre-deployment phase to quickly reconfigure workstation design and assess its impact on workload balancing and task sequencing during the deployment of assembly lines still represents a challenging task considering the available software tools. This research proposes a new mathematical model to accelerate the design of ergonomic human-robot collaborative workstations based on task alternatives and the combined consideration of postural assessment and fatigue analyses for each of them to design an ergo-friendly collaborative environment. Surface electromyography analysis is jointly adopted with postural risk assessment measured with inertial measurement units and developed by a digital ergonomic platform to determine the optimal workplace configuration for tools, equipment, and resources to promote physical well-being while considering station productivity. Experimental tests are performed to investigate arm muscles and postural risk assessment for different configurations of workstation design and collaborative human-robot job progression. Experimental results demonstrate the feasibility, and the advantages of the proposed approach compared to existing simulation software to quickly generate and assess alternative scenarios and find a trade-off between ergo-quality levels and system performance. The final discussion offers valuable information for decision-makers and practitioners to facilitate the integration of human factors throughout the early stages of ergo-friendly workspace design, while effectively managing the complexity generated by resource allocation and collaborative robots
Hydrogen and oxygen isotopic compositions of wall rocks and fault rocks of the Bolfin Fault Zone (Atacama Fault System, Northern Chile)
No full textHydrogen and oxygen isotopic compositions of the hydrogen-bearing mineral phases of wall-rocks and fault-rocks of the Bolfin Fault Zone (Atacama Fault System, Northern Chile
Bronze Age monumental earthworks of the Friuli Plain (NE Italy): from LiDAR-based morphometric analysis to the reconstruction of settlement patterns and organization
No full textIn this study, we use high-resolution data from airborne Light Detection and Ranging (LiDAR) acquisitions to comprehensively analyse late prehistoric earthwork structures in the alluvial plain of Friuli (NE Italy).
By comparing LiDAR-derived models with direct topographic surveys of the structures carried out in the past we provide a detailed overview of the main characteristics of the structures. The new documentation, including Digital Terrain Models (DTMs), profiles and 3D models of the preserved structures, refines the topographic information collected by previous scholars and offers new insights into the development of sophisticated building techniques by Bronze Age communities. Additionally, by converting earthwork volumes into energetics and combining workforce investment analysis with other archaeological proxies—particularly site size and distribution—we have supported the analysis of settlement patterns and organization.
Assuming 100 hypothetical full-time workers, the construction of burial mounds would have required from 1 week to 2 months; phase 3 monumental embankments at Sedegliano, Savalons, and Galleriano forts would have taken 4-10 months while 2.5-4 years at Udine. The Udine mound would have demanded up to 28 times the labour needed for other forts’ embankments, requiring approximately 11 years to complete and likely necessitating additional workforce from nearby settlements. This approach reveals the emergence of a defined hierarchical settlement system in the Friuli plain during the Recent Bronze Age, with the fort of Udine serving as a top-order settlement within a polity of smaller ones, akin to those recognized in the nearby regions of the Po Plain
Visual continuum in non-human animals: Serial dependence revealed in dogs
No full textSerial dependence is a recently described phenomenon by which the perceptual evaluation of a stimulus is biased by a previously attended one. By integrating stimuli over time, serial dependence is believed to ensure a stable conscious experience. Despite increasing studies in humans, it's unknown if the process occurs also in other species. Here, we assessed whether serial dependence occurs in dogs. To this aim, dogs were trained on a quantity discrimination task before being presented with a discrimination where one of the discriminanda was preceded by a task-irrelevant stimulus. If dogs are susceptible to serial dependence, the task-irrelevant stimulus was hypothesized to influence the perception of the subsequently presented quantity. Our results revealed that dogs perceived the currently presented quantity to be closer to the one presented briefly before, in accordance with serial dependence. The direction and strength of the effect were comparable to those observed in humans. Data regarding dogs’ attention during the task suggest that dogs used two different quantity estimation mechanisms, an indication of a higher cognitive mechanism involved in the process. The present results are the first empirical evidence that serial dependence extends beyond humans, suggesting that the mechanism is shared by phylogenetically distant mammals
Simultaneous Expression of Different Therapeutic Genes by Infection with Multiple Oncolytic HSV-1 Vectors (Figure 3-5 and Figure S3)
No full textThis file reports the raw data of Figure 3-5 and of Figure S3 of the manuscript entitled "Simultaneous Expression of Different Therapeutic Genes by Infection with Multiple Oncolytic HSV-1 Vectors" authored by Adriana Vitiello, Alberto Reale,Valeria Conciatori, Anna Vicco, Alfredo Garzino-Demo, Giorgio Palù, Cristina Parolin, Jens Von Einem and Arianna Calistr
PANOMEN-3 grading score is reliable in predicting a pituitary adenoma behavior and prognosis: a single center cohort validation study
Full text linkBackground: Pituitary adenomas comprise a heterogeneous group of diseases, with highly variable clinical manifestations, therapies and prognosis. A validated unified scoring system to guide prognosis and therapy early on is still missing for these patients.
Methods: We prospectively assessed a retrospective large single center cohort of patients with pituitary adenomas followed at our center over the last 24 years using a newly developed Pituitary Society grading system, PANOMEN-3.
Results: In our cohort, with a long follow-up (median>8 yrs), a high initial grade predicted a worse long-term outcome despite multimodal treatments (grade 3, remission OR 0.5, 95%CI [0.24; 0.98], p=0.047). Moreover, grade could predict tumor behaviour following surgery: a higher grade at baseline predicted relapse in cured cases (p=0.014) and a higher postoperative grade predicted the need for additional treatments in case of persisting disease (p=0.04). Interestingly, a score downgrade following failed surgery also prevented further long-term interventions (p=0.01). Moreover, a score downgrade early on for patients treated with primary medical treatment predicted lack of second-tier additional interventions and medically-induced remission.
Conclusion: Our data suggest for the first time that PANOMEN-3 grade system could be useful in everyday clinical practice, aiding physicians in both improving follow-up strategies of cured patients and in the management of persisting disease for all pituitary adenomas. Further multicenter validation studies with prospective design are needed to corroborate our findings, as well as studies evaluating other important patient outcomes such as comorbidities, quality of life and survival
Small bodies geological and geostructural analysis
Full text linkLesson on small bodies geological and geostructural analysis for the GMAP Geology and Planetary Mapping winter schoo