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Investigation of data for decision-support in forest-related natural resources management – with a focus on spatial data on European and national level. Deliverable 1.1. of Working Group 1, COST Action Integrated DSS for delivery of ecosystem services based on EU forest policies (DSS4ES).
Full text linkThis publication is based upon work from COST Action CA22141, DSS4ES, supported by COST (European Cooperation in Science and Technology
A novel prognostic risk model for patients with refractory/relapsed acute myeloid leukemia receiving venetoclax plus hypomethylating agents
Full text linkOff-label hypomethylating agents and venetoclax (HMA/VEN) are often used for relapsed and refractory (R/R) AML patients. However, predictors of outcome are elusive. The objective of the current retrospective observational multicenter study of 240 adult patients (median age 68.6 years) with R/R AML was to establish a prognostic risk score. Overall response was documented in 106 (44%) patients. With a median follow-up of 31.5 months, 179 deaths were recorded. Median overall survival (mOS) was 7.9 months. In multivariate analysis of the subgroup with molecular information (n = 174), risk factors for inferior survival included the presence of extramedullary disease, HMA pretreatment and mutations in NF1, PTPN11, FLT3, and TP53, whereas mutated SF3B1 was identified as favorable risk factor. These risk factors were subsequently applied to construct an HR-weighted risk model that allocated patients to one of three risk groups with significantly different survival outcomes: favorable (n = 46; mOS 21.4 months), intermediate (n = 75; mOS 7.5 months), and adverse (n = 53; mOS 4.6 months; p < 0.001). The model was validated in 189 AML patients treated with HMA/VEN in first line. This clinical-molecular, 3-tiered venetoclax prognostic risk score (VEN-PRS) for HMA/VEN treatment outcomes in R/R AML patients will support the selection of appropriate treatment options in this high-risk population
Déclin de la liberté académique au Maghreb
Full text linkMots-clés : liberté académique, autonomie universitaire, enseignement supérieur, autocratisationKeywords: academic freedom, university autonomy, higher education, autocratisationSchlagworte: akademische Freiheit, Hochschulautonomie, Hochschulbildung, Autokratisierun
On I. Meghea and C. S. Stamin review article “Remarks on some variants of minimal point theorem and Ekeland variational principle with applications,” Demonstratio Mathematica 2022; 55: 354-379
Full text linkBeing informed that one of our articles is cited in the paper mentioned in the title, we downloaded it, and we were surprised to see that, practically, all the results from our paper were reproduced in Section 3 of Meghea and Stamin’s article. Having in view the title of the article, one is tempted to think that the remarks mentioned in the paper are original and there are examples given as to where and how (at least) some of the reviewed results are effectively applied. Unfortunately, a closer look shows that most of those remarks in Section 3 are, in fact, extracted from our article, and it is not shown how a specific result is used in a certain application. So, our aim in the present note is to discuss the content of Section 3 of Meghea and Stamin’s paper, emphasizing their Remark 8, in which it is asserted that the proof of Lemma 7 in our article is “full of errors.
Bulbillosins A - E, azaphilones from Tengochaeta bulbillosa sp. nov. (Chaetomiaceae), a root endophyte of the Chinese medicinal plant Aster tataricus
Full text linkAster tataricus is a plant used in Traditional Chinese Medicine. From its roots, we isolated four endophytic fungi strains. After mass spectrometry analysis and subsequent molecular networking and dereplication, one of the strain’s extracts showed a cluster of yet undescribed natural products. Additionally, the extract was found to be lethal for the nematode Caenorhabditis elegans and cytotoxic against eukaryotic cell lines. The fungal strain was characterized by morphological and molecular studies, allowing its description as a new species in the genus Tengochaeta (Chaetomiaceae), Tengochaeta bulbillosa. After cultivation and extraction of the strain, the major secondary metabolites were isolated. Structure elucidation based on nuclear magnetic resonance spectroscopy and high-resolution tandem mass spectrometry revealed these compounds to be five new azaphilones. Additionally, the localization of these azaphilones in the host plant was studied by mass spectrometry imaging of different plant tissues, revealing that they were mainly localized in the aerial parts of the plant. The main compound, bulbillosin A, was evaluated for its activity against sixty cancer cell lines, revealing a differential cytotoxicity profile
A standardized in vitro bioengineered skin for penetrating wound modeling
Full text linkOver the years, significant progress has been made in developing cost-effective and ethical in vitro bioengineered skin substitutes to study cutaneous wound healing processes. Rodents and small animal models are not optimal due to physiological differences in their skin compared to human skin. The generation of reproducible and precise wounds is key to obtaining comparable results. We created a three-dimensional skin wounding model by growing a fully differentiated, stratified squamous epithelium from human keratinocytes at an air–liquid interface on a type I collagen scaffold concealed with human dermal BJ fibroblasts. To generate the wounds, a stamp with incorporated needles with a length of 250 µm was used to puncture the epidermis to produce standardized wounds. The stamping needle technique is a practical and inexpensive method for creating length-tailored wounds on three-dimensional skin models. The effectiveness of this technique in treating 3D skin models was demonstrated, accompanied by an evaluation of the model’s functionality in terms of cell proliferation, differentiation, and immunological characteristics
Grinding Stone Deposits of the Linear Pottery Culture in Central Germany
Full text linkIn recent years, three deposits of grinding stones have been discovered in Central Germany, resembling a phenomenon known from the Paris Basin and Belgium. These deposits were more than simple disposals; they likely held ritual or symbolic significance, reflecting the values and beliefs of the community. Their symbolism is diverse, shaped by both the tools themselves and their locations. The condition of the tools—ranging from new to nearly worn-out—adds layers of meaning, suggesting cycles of creation, use, and obsolescence. These symbols, such as fertility, life cycles, and territorial markers, mirror the daily and yearly rhythms of agrarian life. Additionally, they represent human biographies and social relationships, often emphasizing transitional moments such as birth, marriage, and death. A techno-functional analysis of the grinding tools highlights time as a central theme, symbolized through daily routines, seasonal cycles, and human lifespans. Overall, these interpretations reveal the complex and multifaceted nature of the grinding stone deposits, offering valuable insights into the worldviews and practices of past societies
Dissecting the mechanism of nuclear restitution in Arabidopsis male meiosis
Full text linkMeiosis is essential for the successful development of haploid germline cells. Recent studies on the Arabidopsis jason (jas) mutant revealed that an organelle band plays a key role in spindle separation during simultaneous cytokinesis. This study focused on a novel jas suppressor mutant, peleus (pel), which restores haploid pollen production in the jas background. PEL encodes a vacuole-localized protein that negatively regulates chromosome distance during metaphase II by modulating secretory trafficking. JAS, PEL, and the ubiquitin-like protein (UBQL) coordinate the delivery of proteins and membrane components to the organelle band. PEL and UBQL antagonistically inhibit the secretory trafficking driven organelle band formation. Our findings underscore the critical role of secretory trafficking in maintaining organelle band integrity and ensuring precise chromosome distance during meiosis II. This research provides new insights into the unreduced gametes formation and application in plant breeding
Herbarium specimens reveal a cryptic invasion of polyploid Centaurea stoebe in Europe
Full text linkNumerous plant species are expanding their native ranges due to anthropogenic environmental change. Because cytotypes of polyploid complexes often show similar morphologies, there may be unnoticed range expansions (i.e. cryptic invasions) of one cytotype into regions where only the other cytotype is native.
We critically revised herbarium specimens of diploid and tetraploid Centaurea stoebe, collected across Europe between 1790 and 2023. Based on their distribution in natural and relict habitats and phylogeographic data, we estimated the native ranges of both cytotypes.
Diploids are native across their entire European range, whereas tetraploids are native only to South-Eastern Europe and have recently expanded their range toward Central Europe. The proportion of tetraploids has exponentially increased over time in their expanded but not in their native range. This cryptic invasion predominantly occurred in ruderal habitats and enlarged the climatic niche of tetraploids toward a more oceanic climate.
We conclude that spatio-temporally explicit assessments of range shifts, habitat preferences and niche evolution can improve our understanding of cryptic invasions. We also emphasize the value of herbarium specimens for accurate estimation of species´ native ranges, with fundamental implications for the design of research studies and the assessment of biodiversity trends