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Liiketoiminnan ja järjestelmäkehityksen yhteensovittaminen ketterän kokonaisarkkitehtuurin avulla
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Assessment of gold mineralization potential in the Tanzania Craton based on stream sediment geochemistry multivariate analysis and regression modeling
Get PDFThe artisanal and small-scale mining (ASSM) sector has contributed to economies and is an integral component of the drivers of the gross domestic product (GDP) of most developing countries. To enhance the production of the ASSM sector, most gold (Au) endowed countries have supported the sector’s activities in diverse ways. However, despite this support, several factors, including poor exploration targeting, still affect the sector's production. This study, therefore, seeks to characterize the gold (Au) mineralization and its spatial distribution in the Singida region of the Tanzania Craton with a focus on identifying potential Au mineralized zones that could be demarcated and targeted for ASSM activities and further exploration exercises within the region. The study leverages stream sediment geochemical results to identify the elemental associations and pathfinder elements using multivariate statistics (Principal component analysis), multilinear regression modeling, and spatial distribution of Au and the pathfinder elements within the study area. The Au deposits in the area are strongly associated with the elements; Ni, Cr, V, Mg, Fe, Cu, and Al. Palladium (Pd), platinum (Pt), arsenic (As), and copper (Cu) are the main pathfinder elements in the area. Lead is not directly related to Au from the study. Mafic, ultramafic rocks, and clays are the most probable sources of Au in the area. Gold concentrations are focused on the southwestern fringes of the area. Southwestern, central south, and southeastern fringes of the area should also be explored considering the distribution of the dominant pathfinder elements. Alluvial and lateritic materials are also worth exploring.</p
Finland’s Famous Education System : Unvarnished Insights into Finnish Schooling
No full textAlthough inclusive education is a strong trend in education policy around the globe, there are different definitions and variations used in different nations. The case of Finland is interesting, because the long-term direction of the Finnish school system has supported every child’s right to participate in education, but inclusive education is not mentioned or defined anywhere in education legislation. This absence of definition not only leaves the defining to the parties concerned, but also adds to creating inclusive myths and varying realities in everyday life. Meanwhile, in public discussion, there has been a constant and quite polarised debate about putting students with support needs in regular classrooms. The recent Government Program (2019) in Finland states that special education legislation should be investigated from the point of view of students as well as teachers’ wellbeing. In order to define the current state and equality of the Finnish support system, the Ministry of Education and Culture has established a working group as part of the “Right to Learn” initiative 2020–2022. In this chapter, we discuss the historical development of Finnish inclusion and contrast myths and realities of the Finnish model in supporting students with support needs in the light of international trends in inclusive and special education. We also discuss possible future trends of inclusive education in the Finnish context.</p
Structural variations in copper(II) amine-bisphenolate complexes: Evaluation of in vitro antiproliferative activity against human cancer and normal cells
Get PDFThree copper(II) complexes with variously substituted amine-bisphenolates (H2L1, H2L2 and H2L3) have been prepared. Variation in the composition and structure of the free ligands resulted in the formation of three structurally distinct copper(II) complexes: dinuclear 1, mononuclear 2 and trinuclear 3. Various physical techniques were used to characterise the complexes, including single-crystal X-ray analysis and variable-temperature magnetic susceptibility measurements (5-297 K). The compounds were evaluated for their in vitro anti-proliferative effects against three human cancer cell lines (ovarian A2780 and A2780R, breast MCF7) and normal HaCaT cells. The results showed that both the free ligands and the complexes exhibit strong-to-moderate cytotoxicity. 2 and 3 are significantly more effective against A2780, A2780R and MCF7 cells than the metallodrug cisplatin. The cytotoxicity of complexes 1-3 is bound to the cytotoxicity of the free ligands and remains almost unchanged over 24, 48 and 72 h. The copper accumulation in A2780 cells was studied by ICP-MS over 2-72 h of co-incubation of 1-3. Complex 1 caused the highest uptake of copper into A2780 cells, reaching up to 100 times higher Cu concentration compared to untreated cells, while 2 and 3 showed only ca 5-10-fold increase of Cu uptake in A2780 cells. No apparent signs of hydrolysis of 1-3 in a MeOH/water mixture were observed in mass spectrometry experiments even after 72 h of standing at laboratory temperature. The mass spectrometry-based interaction studies of 1-3 with L-cysteine (Cys) and reduced glutathione (GSH) did not show direct evidence of the interaction product formation. Only the signals, corresponding to the free ligands were identified in mass spectra after 24 h and 72 h of incubation
Social and moral psychology of COVID-19 across 69 countries
Get PDFThe COVID-19 pandemic has afected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.</p
Morbid obesity and type 2 diabetes alter intestinal fatty acid uptake and blood flow
Get PDFAims: Bariatric surgery is the most effective treatment to tackle morbid obesity and type 2 diabetes, but the mechanisms of action are still unclear. The objective of this study was to investigate the effects of bariatric surgery on intestinal fatty acid (FA) uptake and blood flow. Materials and Methods: We recruited 27 morbidly obese subjects, of whom 10 had type 2 diabetes and 15 were healthy age-matched controls. Intestinal blood flow and fatty acid uptake from circulation were measured during fasting state using positron emission tomography (PET). Obese subjects were re-studied 6 months after bariatric surgery. The mucosal location of intestinal FA retention was verified in insulin resistant mice with autoradiography. Results: Compared to lean subjects, morbidly obese subjects had higher duodenal and jejunal FA uptake (P </p
Myocardial Work, an Echocardiographic Measure of Post Myocardial Infarct Scar on Contrast-Enhanced Cardiac Magnetic Resonance
Get PDFThis study investigates the relation of non-invasive myocardial work and myocardial viability following ST-segment elevation myocardial infarction (STEMI) assessed on late gadolinium contrast enhanced cardiac magnetic resonance (LGE CMR) and characterizes the remote zone using non-invasive myocardial work parameters. STEMI patients who underwent primary percutaneous coronary intervention (PCI) were included. Several non-invasive myocardial work parameters were derived from speckle tracking strain echocardiography and sphygmomanometric blood pressure, e.g.: myocardial work index (MWI), constructive work (CW), wasted work (WW) and myocardial work efficiency (MWE). LGE was quantified to determine infarct transmurality and scar burden. The core zone was defined as the segment with the largest extent of transmural LGE and the remote zone as the diametrically opposed segment without LGE. A total of 53 patients (89% male, mean age 58 ± 9 years) and 689 segments were analyzed. The mean scar burden was 14 ± 7% of the total LV mass, and 76 segments (11%) demonstrated transmural hyperenhancement, 280 (41%) non-transmural hyperenhancement and 333 (48%) no LGE. An inverse relation was observed between segmental MWI, CW and MWE and infarct transmurality (p < 0.05). MWI, CW and MWE were significantly lower in the core zone compared to the remote zone (p<0.05). In conclusion, non-invasive myocardial work parameters may serve as potential markers of segmental myocardial viability in post-STEMI patients who underwent primary PCI. Non-invasive myocardial work can also be utilized to characterize the remote zone, which is an emerging prognostic marker as well as a therapeutic target
Foot health and quality of life of nursing students: an exploratory multimethod study
Get PDFIntroduction: Foot health is often neglected in healthcare, despite its importance for nursing students, who spend long periods standing and walking. Objective: To explore the relationship between foot health, quality of life, and knowledge among nursing students in a clinical education setting. Methods: A sequential multimethod exploratory study was conducted with 54 students, selected through purposive snowball sampling. Assessments took place at month 0 and month 5 to analyze changes in clinical exposure. Results: Changes in quality of life were observed, particularly in “pain/discomfort” and “anxiety/depression.” Foot problems were common, including cold feet (57.4%) and calluses (29.6%), with limited awareness of structural foot deformities. Significant correlations emerged, including a strong association between blisters and “pain/discomfort” at month 0 (0.614; p Conclusion: This study highlights the intricate relationship between foot health and the quality of life of nursing students, advocating for ergonomic interventions and footwear improvements to enhance physical and mental well-being.</p
Change in functioning profile after cervical surgery
Get PDFThe objectives are to (a) introduce an approach to use the Neck Disability Index (NDI) in a way, which is different and more International Classification of Functioning, Disability and Health-oriented than acommon practice - focusing on functional profile instead of composite score only, and (b) to describe the changes in functioning experienced by patients undergoing cervical surgery. This was a register-based study of almost 400 patients undergoing different cervical surgical procedures in a university hospital between 2018 and 2021. The patients responded to repeated surveys preoperatively and 3, 12 and 24 months postoperatively. Linear regression test was performed to analyze the change of the NDI score. The changes in scores during a follow-up were statistically significant (P < 0.001) for all the NDI items as well as for the total score. Each item demonstrated significant improvement postoperatively and a slight worsening between 1 and 2 years after the surgery. The observed slight decline in functioning at the end of follow-up remained below the baseline level for all the items. While the change in the composite score of the NDI was able to describe the overall change in functioning after the surgery, different areas of functioning were affected by the surgery differently. The results suggest that the use of functional profiles, in addition to composite scores, is justified among patients with cervical pathologies.</p
