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Digitale Verschwendung und digitale Nachhaltigkeit: Zur gesellschaftlichen Konstruktion problematischer Verhaltensweisen
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Minimalinvasive Therapie der Mitralklappeninsuffizienz: Entwicklung von Methoden zur Beurteilung innovativer Implantatdesigns und Implantationsstrategien
Get PDFDie Versorgung der Mitralklappeninsuffizienz mithilfe der minimalinvasiven Mitralklappenreparatur ist von erheblicher Bedeutung für die Erhaltung bzw. Wiederherstellung der gesundheitsbezogenen Lebensqualität von Patientinnen und Patienten weltweit. Im Rahmen der vorliegenden Arbeit sind sowohl fluidmechanische Prüfmethoden als auch numerische Fluid-Struktur-Interaktionsmodelle für die Beurteilung aktueller und die Konzeptionierung neuer Clipimplantatdesigns und Implantationsstrategien entwickelt worden.Minimally invasive mitral valve repair as a treatment procedure for mitral regurgitation is of vital importance for maintaining and/or restoring the health-related quality of patients' lives. In the present work, both fluid mechanical test methods and numerical fluid-structure interaction models have been developed as novel tools for the evaluation of current and the design of new clip implant designs and corresponding implantation strategies
Spatial and temporal variability in the Northeast Atlantic Subtropical gyre and implications for the biogeochemistry of the region
Get PDFOcean circulation distributes heat, salt, and nutrients through the different basins. Thus, changes in circulation will ultimately impact the biogeochemistry of the ocean. In this work, the variability of currents and water column properties were studied in the Northeast Subtropical Atlantic, together with changes in the biogeochemistry in the upper 300 m over the North Atlantic Subtropical gyre. It was found that ocean circulation and biogeochemistry in the North Atlantic underwent drastic changes since the 1960s, leading to a reduction in the CO2 uptake by the oceans in the last 100 years
Koordinationschemische Gerüstverbindungen für lichtinduzierte Elektronentransferprozesse
Get PDFEs wurden zum einen redox-aktive side-on koordinierte W-Alkinkomplexe des Typs [Tp*W(CO)Br((C5H4N)CCE)] (E = CH3, CH2-PPh2, PPh2) synthetisiert und anschließend an Metallzentren (M = Ir, Ru, Pd) koordiniert. Zum anderen wurden NAD/NADH-Modell-Liganden auf der Basis von 1,10-Phenanthrolin synthetisiert und als Bestandteile von Ir- und Ru-Komplexverbindungen genauer betrachtet. Die unterschiedlichen Ligandensysteme wurden umfassend spektroskopisch charakterisiert und ihre Eignung als Bestandteile von Komplexverbindungen, die lichtinduzierte Elektronentransferreaktionen eingehen, beurteilt.In this work, redox-active side-on coordinated W-alkyne complexes of the type [Tp*W(CO)Br((C5H4N)CCE)] (E = CH3, CH2-PPh2, PPh2) were synthesized and subsequently coordinated to metal centers (M = Ir, Ru, Pd). In the second part of this work, NAD/NADH model ligands based on 1,10-phenanthroline were synthesized and investigated within iridium and ruthenium coordination compounds. The different ligand systems were characterized spectroscopically and their suitability as components in coordination compounds undergoing light-induced electron transfer reactions were discussed
The relationship between exposure of air pollutants and health effects
Get PDFExposure to air pollutants including polycyclic aromatic hydrocarbons (PAHs) was linked to acute and chronic health effects. Comprehensive evidence is still limited. Thus we developed robust and sensitive analytical methods to jointly investigate the interplay between the biomarkers of PAHs, oxidative stress, and health profiles. Moreover, we proposed a concept of non-invasively using travelers between locations of different particulate matter (PM) concentrations as a simple and cost-effective model to investigate acute health effects from exposure to air pollutants
Exploring the relationship between dysregulation in the lipid metabolism and the pathological hallmarks of Alzheimer’s disease
Get PDFThis doctoral dissertation explored novel biomarkers that could reinforce diagnostic accuracy and predict disease progression in the early phases of AD. Such biomarkers are expected to allow the stratification of individuals based on the risk associated with their specific pathology burden, i.e., region-specific cortical amyloidosis and lipids dysregulations. Both approaches enabled higher precision in research participants' characterization, which could be crucial in planning clinical trials and adopting new interventions in prevention trials.In dieser Dissertation wurden neue Biomarker untersucht, die die diagnostische Genauigkeit verbessern und das Fortschreiten der Alzheimer-Krankheit in den frühen Phasen vorhersagen könnten. Es wird erwartet, dass sie Risiko basierte Stratifizierung von Personen ermöglichen, die mit ihrer spezifischen Krankheitslast verbunden sind, d.h. kortikale Amyloidose und Lipidstörungen. Beide Ansätze ermöglichten eine präzisere Charakterisierung der Probanden, was für die Planung klinischer Studien und die Annahme neuer Maßnahmen in Präventionsstudien entscheidend sein könnte
Distress analysis of mice used for translational research: reflection of a surgeon on animal welfare
Get PDFThe assessment and improvement of animal welfare is not only an ethical requirement, but also a guarantee of efficient and high quality translational research. In recent years, sophisticated animal models were created to study human diseases. However, the assessment of distress in these animal models is scarce. In order to provide a solid basis for optimizing animal welfare in future studies, body weight, burrowing, nesting activity, faecal corticosterone metabolites (FCMs), and distress scores were analyzed in several animal models