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Fast forward digital: A new kind of university
Get PDFThe student is the centre of our universe, our only true asset, our raison
d’être. Not research. Not the government. Not societal impact. The digital
world has shown the devastating impact if we get this wrong. We can only
succeed if we mobilise our students and alumni and reach out to all learners.
We must reverse the dependency. Why not give students the money as
Educoins in our educational blockchain? Let them decide. Make them
co-creators in our research.
In his valedictory address, Professor Peter Vervest explores the disruptive
effects of digitalisation on business and extrapolates what this will mean for
university education and research. He argues in favour of digitally enabled,
personalised learning paths and support for students combined with
modularisation of the learning portfolio and challenge-based engagement
of students in the research agenda. Education and research are two sides of
the same coin. In the digital world, universities can succeed if they digitally
reach out to students and alumni to engage in ongoing research and learning.
This requires deep investments in digital technologies and a profound
transformation of the university system and metrics
Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease and cancer
Get PDFFor many years, the dogma has been that insulin resistance precedes the development of hyperinsulinemia. However, recent data suggest a reverse order and place hyperinsulinemia mech-anistically upstream of insulin resistance. Genetic background, consumption of the “modern” Western diet and over‐nutrition may increase insulin secretion, decrease insulin pulses and/or reduce hepatic insulin clearance, thereby causing hyperinsulinemia. Hyperinsulinemia disturbs the balance of the insulin–GH–IGF axis and shifts the insulin: GH ratio towards insulin and away from GH. This insulin–GH shift promotes energy storage and lipid synthesis and hinders lipid breakdown, resulting in obesity due to higher fat accumulation and lower energy expenditure. Hyperinsuline-mia is an important etiological factor in the development of metabolic syndrome, type 2 diabetes, cardiovascular disease, cancer and premature mortality. It has been further hypothesized that nu-tritionally driven insulin exposure controls the rate of mammalian aging. Interventions that normal-ize/reduce plasma insulin concentrations might play a key role in the prevention and treatment of age‐related decline, obesity, type 2 diabetes, cardiovascular disease and cancer. Caloric restriction, increasing hepatic insulin clearance and maximizing insulin sensitivity are at present the three main strategies available for managing hyperinsulinemia. This may slow down age‐related physiological decline and prevent age‐related diseases. Drugs that reduce insulin (hyper) secretion, normalize pulsatile insulin secretion and/or increase hepatic insulin clearance may also have the potential to prevent or delay the progression of hyperinsulinemia‐mediated diseases. Future research should focus on new strategies to minimize hyperinsulinemia at an early stage, aiming at successfully pre-venting and treating hyperinsulinemia‐mediated diseases
Emerging tools for bioluminescence imaging
Get PDFBioluminescence (BL) relies on the enzymatic reaction between luciferase, a substrate conventionally named luciferin, and various cofactors. BL imaging has become a widely used technique to interrogate gene expression and cell fate, both in small and large animal models of research. Recent developments include the generation of improved luciferase–luciferin systems for deeper and more sensitive imaging as well as new caged luciferins to report on enzymatic activity and other intracellular functions. Here, we critically evaluate the emerging tools for BL imaging aiming to provide the reader with an updated compendium of the latest developments (2018–2020) and their notable applications
Autoimmune Encephalitis and Epilepsy
Get PDFThis thesis gives an overview of autoimmune encephalitis and epilepsy, focusing on recognition, diagnosis and treatment of these syndromes. It also describes clinical symptoms and long-term outcome of autoimmune encephalitis in children
‘Vroeger zaten d’r ook echt arbeiders in de Kamer, nu niet één’
Get PDFPhilip van Praag liet in het vorige nummer van S&D zien dat in Nederland een nieuwe vorm van verzuiling aan het ontstaan is tussen praktisch en theoretisch geschoolden, waarbij praktisch geschoolden steeds minder vaak ‘links’ stemmen.
Politieke partijen die deze nieuwe verzuiling willen doorbreken moeten er beter op letten dat ook praktisch geschoolden zich door hen vertegenwoordigd weten in de politieke arena
Het systeem van sanctionering van fiscale fraude: Een onderzoek naar de voorzienbaarheid en onderlinge afstemming van sanctioneringsmogelijkheden.
Get PDFThe system of sanctioning tax fraud viewed in the light of foreseeability and ne bis in idem
The elimination of disease and burden of disease
Get PDFThis thesis discusses the elimination of disease and burden of disease. In the first part, this thesis outlines the cost-effectiveness of several strategies contribution to hepatitis C elimination. In the second part, this thesis assess if antiviral resistance proposes a barrier towards the hepatitis C elimination goals. The final part focusses on HIV, a chronic disease, where the disease burden plays an important role
Subline frequency setting for autonomous minibusses under demand uncertainty
Get PDFOver the last years, there have been initiated several pilots with autonomous minibusses. Unlike regular bus services, autonomous minibusses serve a limited number of stops and have more flexible schedules since they do not require bus drivers. This allows the operation of a line through a flexible combination of sublines, where a subline serves a subset of consecutive stops in the same order as the original line. This paper studies the subline frequency setting (SFS) problem under uncertain passenger demand. We present a frequency setting model that assigns autonomous minibusses to sublines in order to exploit the available resources as much as possible and minimize the operational and passenger waiting time costs. Passenger waiting time costs may depend on the combination of several lines whose frequencies cannot be perfectly aligned for each passenger journey. We present a new estimation of the expected waiting time for passengers to improve the accuracy of the passenger waiting time costs in the case of sublines. Our SFS model is originally formulated as a MINLP and reformulated as a MILP that can be solved to global optimality. Further, we explicitly consider the uncertainty of passenger demand in the optimization process by formulating a stochastic optimization model. The performances of our stochastic and deterministic models that assign minibusses to sublines are tested under various passenger demand scenarios in the 14-stop autonomous minibus line in Eberbach, Germany and a fictional bus line with 20 bus stops. Results show potential improvements in operational costs in the range of 10-40% depending on the passenger demand profile