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Glycosylated BODIPY- incorporated Pt(II) metallacycles for targeted and synergistic chemo-photodynamic therapy [dataset]
No full textPt(II)-BODIPY complexes combine the chemotherapeutic activity of Pt(II) with the photocytotoxicity of BODIPYs. Additional conjugation with targeting ligands can boost the uptake by cancer cells that overexpress the corresponding receptors. We describe two Pt(II) triangles, 1 and 2, built with pyridyl BODIPYs functionalized with glucose (3) or triethylene glycol methyl ether (4), respectively. Both 1 and 2 showed higher singlet oxygen quantum yields than 3 and 4, due to the enhanced singlet-to-triplet intersystem crossing. To evaluate the targeting effect of the glycosylated derivative, in vitro experiments were performed using glucose transporter 1 (GLUT1)-positive HT29 and A549 cancer cells, and noncancerous HEK293 cells as control. Both 1 and 2 showed higher cellular uptake than 3 and 4. Specifically, 1 was selective and highly cytotoxic toward HT29 and A549 cells. The synergistic chemo- and photodynamic behavior of the metallacycles was also confirmed. Notably, 1 exhibited superior efficacy toward the cisplatin-resistant R-HepG2 cells
Medición del Acceso Abierto en las universidades españolas y el CSIC (2018-2022)
No full textMedición del acceso abierto en las universidades y centros de investigación del CSIC, periodo 2018-2022, realizada por el Subgrupo de Acceso Abierto de la Línea II del Plan Estratégico de REBIUN (Red de Bibliotecas Universitarias Españolas)
Controlling the reactivity of phthalonitriles for the efficient synthesis of chiral phthalocyanines with self-assembly abilities [dataset]
No full textBinaphthol-bridged phthalonitriles are common precursors for the preparation of chiral phthalocyanines (Pcs). However, self-condensation of these phthalonitriles usually leads to the target Pcs in extremely low yields. In this work, we report a smart approach to enhance the reactivity towards self-condensation of binaphthol-bridged phthalonitriles, which relies on the addition of another highly reactive phthalonitrile that initiates the macrocyclization process, but it is eventually released. After optimization of the reaction conditions, ethynyl-containing binaphthyloxy-bridged Zn(II)Pc (AA)2-2 has been obtained in remarkable yields. This Pc synthon has been further endowed with hydrophilic cationic tails, giving the strongly amphiphilic Zn(II)Pc 1, which has shown the ability to form nanostructures in aqueous solutions
Absell-Federico-Tena World Trade Historical Database 1948-2020 : Fiji
No full textProject developed by Christopher Absell (University Gothenburg and Instituto Figuerola) Giovanni Federico (New York University Dubai) and Antonio Tena Junguito (Universidad Carlos III de Madrid and Instituto Figuerola). Dataset: Fij
Absell-Federico-Tena World Trade Historical Database 1948-2020 : Uzbekistan
No full textProject developed by Christopher Absell (University Gothenburg and Instituto Figuerola) Giovanni Federico (New York University Dubai) and Antonio Tena Junguito (Universidad Carlos III de Madrid and Instituto Figuerola). Dataset: Uzbekista
DATARQUIFAUR
No full textInformación básica generada por el proyecto de investigación ARQUIFAUR haciendo uso de los datos registrados en colaboración con la ciudadanía que formó parte del proyecto, durante el laboratorio ciudadano CRAI Ciudadan@.
Proyecto de investigación que explora y registra las aves que habitan la ciudad histórica de Alcalá en función de los servicios que está ofrece. El proyecto ha realizado principalmente tres labores. Una primera toma de datos llevada a cabo en colaboración con la ciudadanía en 33 sitios de la ciudad. Una segunda que trata de un estudio pormenorizado y en volumen de tres parches de la ciudad: La plaza de Las Bernardas-Plaza Palacio-Plaza Padre Lecanda, Plaza Cervantes-Plaza San Diego y Facultad de Filosofía y Letras con el convento Trinitarios. Y por último una serie de propuestas de intervención en estos tres parches con el objetivo de mejorar los servicios que se ofrece a la biodiversidad.</p
Absell-Federico-Tena World Trade Historical Database 1948-2020 : Ghana
No full textProject developed by Christopher Absell (University Gothenburg and Instituto Figuerola) Giovanni Federico (New York University Dubai) and Antonio Tena Junguito (Universidad Carlos III de Madrid and Instituto Figuerola). Dataset: Ghan
Interview in Spain 26
No full textThe reemergence of China is changing the world, and that EU needs to develop a long-term approach based on research-based knowledge in order to engage strategically with an increasingly assertive China.
This dataset consists of a semi-structured interview with a person of Chinese nationality, carried out in Chinese and transcribed in Chinese language.</p
Absell-Federico-Tena World Trade Historical Database 1948-2020 : Sudan
No full textProject developed by Christopher Absell (University Gothenburg and Instituto Figuerola) Giovanni Federico (New York University Dubai) and Antonio Tena Junguito (Universidad Carlos III de Madrid and Instituto Figuerola). Dataset: Suda
Absell-Federico-Tena World Trade Historical Database 1948-2020 : Gambia
No full textProject developed by Christopher Absell (University Gothenburg and Instituto Figuerola) Giovanni Federico (New York University Dubai) and Antonio Tena Junguito (Universidad Carlos III de Madrid and Instituto Figuerola). Dataset: Gambi