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    Mirror Neurons in Monkey Frontal and Parietal Areas

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    Mirror neurons (MNs) are a class of cells in the fronto-parietal regions of the primate brain that activate during both action execution and observation. Over three decades, numerous neurophysiological studies have investigated the properties of MNs, proposing their involvement in social interaction. However, variability in definitions, recorded brain regions, and response dynamics has posed challenges to replicating MN findings and achieving a comprehensive understanding of their properties. Here, we present a curated dataset of hundreds of single neurons from multielectrode recordings in three fronto-parietal areas (AIP, F5, F6) of macaques executing and observing a reach-to-grasp task. In addition to motor neurons, many cells responded to both executed and observed actions, thus fulfilling the MN criteria. The dataset includes spike times and behavioural events in HDF5 format, a standard for neuroscience data sharing, along with example MATLAB and Python code for dataset exploration and analysis. This resource offers a platform for investigating MNs across different brain areas and task conditions, enabling data-driven hypothesis-testing of their motor and social properties

    Outcomes in patients with chronic heart failure undergoing non-cardiac surgery: a secondary analysis of the METREPAIR international cohort study*

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    Introduction: Heart failure is a frequent comorbidity in patients undergoing non-cardiac surgery and an acknowledged risk factor for postoperative mortality. The associations between stable chronic heart failure and postoperative outcomes have not been explored extensively. The aim of this study was to determine associations between stable chronic heart failure and its peri-operative management and postoperative outcomes after major non-cardiac surgery. Methods: This is a secondary analysis of MET-REPAIR, an international prospective cohort study including patients undergoing non-cardiac surgery aged ≥ 45 y with increased cardiovascular risk. Main exposures were stable chronic heart failure and availability of a pre-operative transthoracic echocardiogram. The primary endpoint was the incidence of postoperative major adverse cardiovascular events at 30 days. Secondary endpoints included 30-day mortality and severe in-hospital complications. Multivariable logistic regression models were calculated. Results: Of 15,158 included patients, 3880 (25.6%) fulfilled the diagnostic criteria for stable chronic heart failure, of whom 1397 (36%) were female. Chronic heart failure was associated with increased risk of postoperative 30-day major adverse cardiovascular events (OR 2.04, 95%CI 1.59–2.60), 30-day mortality (OR 1.50, 95%CI 1.17–1.92) and in-hospital complications (OR 1.47, 95%CI 1.30–1.66). Transthoracic echocardiography was performed in 1267 (32.7%) patients with heart failure; 146 (11.5%) patients with heart failure presented with a left ventricular ejection fraction < 40%. Reduced ejection fraction was associated with major adverse cardiovascular events (OR 2.0, 95%CI 1.01–3.81). Discussion: Stable chronic heart failure is independently associated with major adverse cardiovascular events, mortality and severe postoperative complications when measured 30 days after non-cardiac surgery

    Analisi dei dati nella gestione dei rifiuti urbani nel comune di Fidenza

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    Le modalità di gestione dei rifiuti in generale, e di quelli urbani in particolare, ha conosciuto un’importante evoluzione negli ultimi decenni e con essa sono cambiati i criteri con i quali se ne valuta la qualità. Se, inizialmente, il servizio aveva il principale obiettivo di smaltimento dei rifiuti e quindi si traduceva principalmente in una questione di igiene urbana, nel corso del tempo si sono aggiunti altri fattori inerenti alla qualità del servizio fornito. A rendere ancora più personalizzato e articolato il servizio è stata l’introduzione della tariffazione/tassa puntuale del rifiuto residuo, che ha introdotto una proporzionalità tra quantitativo di rifiuto indifferenziato prodotto e importo della tariffa applicata al singolo utente. Con l’aggiornamento degli obiettivi normativi, pianificatori e regolatori, si sono progressivamente modificati i parametri per valutarne il raggiungimento. In questo lavoro si vogliono proporre procedure semplici e ripetibili, rivolte ai gestori del servizio, in grado di supportare il monitoraggio della qualità del servizio e di individuare opportunità o potenziali criticità, anche legate ad un sistema di tariffazione puntuale di recente attivazione. Si riportano i risultati ottenuti relativi al caso della gestione dei rifiuti urbani e da spazzamento stradale nel Comune di Fidenza, gestito dalla società in house providing San Donnino Multiservizi Srl. Si vuole inoltre proporre una procedura per individuare, relativamente a ciascun turno del servizio di raccolta, quelle utenze per le quali viene effettuata la sosta per la raccolta ma in cui non si ha la lettura di avvenuto svuotamento del bidone dell’indifferenziato. Ciò può avere diverse cause, ma la loro identificazione rappresenta il punto di partenza per approfondire in un secondo momento se la mancata lettura è imputabile all’attrezzatura o a un comportamento errato dell’utenza. Per raggiungere questi obiettivi si sono utilizzati software quali Knime (Bertold et al., 2008), QGIS (2014) oltre che strumenti base quali Excel e i software utilizzati per gestire la strumentazione di lettura dei bidoni e tenere monitorata la flotta di mezzi. Uno degli obiettivi è quello di evidenziare come l’utilizzo di software sviluppati nell’ambito dell’analisi dei dati fornisca vantaggi di velocità e chiarezza delle operazioni compiute, generando workflow facilmente applicabili a set di dati riguardanti periodi temporali o ambiti territoriali different

    Introduction to «The Musealization of Performance art. Acquiring, Conserving, Exhibiting, and Reenacting»

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    Performance art, as a practice of immediacy and instant gesture, is not in principle destined to become an object of collection and exhibition. Indeed, unlike durable, material art forms such as painting and sculpture, performance art carries with it the idea of the obsolescence of the art object, and is structured around a bodily action that is necessarily ephemeral and immaterial. And yet, despite the impossibility of storing it in storage or exhibiting it on a picture rail or pedestal, performance art has gradually made its way into museums, and since the early 2000s has become the object of an ever-growing number of curatorial practices. How is a creation that sets itself up against all forms of durability and materiality likely to become part of a museum's collections? In which form is it acquired, conserved and passed on to the public? In other words, what processes and strategies are used to transform it into a museum object? In concrete terms, the musealization of the performance is achieved by preserving all the documents associated with it. Video or film recordings, photographs, sketches, notes, correspondence, certificates and other objects are all material traces of what existed before, which the museum sometimes treats as archives, sometimes as genuine collection and exhibition objects

    Determinazione di luoghi. Ordine delle operazioni enunciative

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    Secondo la teoria delle operazioni enunciative di Culioli (1983), in linea di principio deve essere seguito, nell’atto di enunciare, un ordine nella collocazione dei termini utilizzati nel discorso. In modo simile alle massime di Grice (1975), la mancata osservanza di tale concatenamento viene sfruttata per creare determinate implicature (Laurencio 2022). Su tali strategie discorsive cercheremo di approfondire in questo lavoro, soffermandoci sulle operazioni linguistiche che si eseguono nel parlare di luoghi o espressioni locative. Le osservazioni fatte ci permetteranno di difendere la necessità di una didattica basata su una grammatica delle operazioni.Según la teoría de las operaciones enunciativas de Culioli (1983), en principio debe seguirse, al enunciar, un orden en el emplazamiento de los términos manejados en el discurso. Lo mismo que con las máximas de Grice (1975), el incumplimiento de tal encadenamiento se aprovecha para crear determinadas implicaturas (Laurencio 2022). Sobre esto intentaremos detenernos en este trabajo, concentrándonos en las operaciones lingüísticas que se ejecutan al hablar de lugares o de expresiones locativas. Las observaciones realizadas nos permitirán defender la necesidad de una didáctica basada en una gramática de operaciones

    Atrial Fibrillation Is Associated With Increased In-Hospital and 1-Year Mortality in Patients Receiving Hemodialysis With ST Elevation Myocardial Infarction: A Retrospective Cohort Study

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    Rationale & Objective: Atrial fibrillation (AF) is highly prevalent among patients receiving maintenance hemodialysis (HD) and patients with ST elevation myocardial infarction (STEMI). We investigated the association of AF with in-hospital mortality, 1-year mortality, and 1-year readmission for acute myocardial infarction (AMI) in HD patients admitted with STEMI. Study Design: Retrospective cohort study based on a large administrative database. Setting & Participants: 138,939 patients admitted with STEMI from 2003-2018, of whom 1,185 (8.5%)receiving HD, followed from the date of admission until death, migration, or 1 year after discharge. Exposures: STEMI (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] 410.x) as the primary discharge diagnosis, maintenance HD (ICD-9-CM 39.95; 54.98; V560; V5 63.1; V563.2), and AF (ICD-9-CM 427.31). Outcomes: In-hospital all-cause mortality (primary outcome), 1-year all-cause mortality, and 1-year readmission for AMI (secondary outcomes). Analytical Approach: Multivariable logistic regression and multivariable Cox regression. Results: One hundred and ninety-five out of 1,185 (16.5%) patients had AF at admission or developed AF during hospitalization. After adjusting for possible confounders, AF versus sinus rhythm was associated with higher in-hospital mortality (odds ratio [OR] = 1.57; 95% confidence interval [CI], 1.11-2.22). AF was associated with higher 1-year mortality (hazard ratio [HR] = 1.45; 95% CI, 1.18-1.76), whereas it was not associated with higher 1-year readmission for AMI (HR = 1.05; 95% CI, 0.72-1.53). Less than 20% of patients with AF discharged alive were prescribed oral anticoagulant therapy. In this subgroup, oral anticoagulant therapy was associated with lower 1-year mortality (HR = 0.46; 95% CI, 0.24-0.89). Limitations: Potential bias due to incorrect or incomplete coding, retrospective design, incidence of thromboembolic events after discharge, and cause of 1-year mortality unknown. Conclusions: AF is highly prevalent and associated with adverse short-and long-term outcomes in HD patients admitted with STEMI

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