Archivio istituzionale della Ricerca - Università degli Studi di Parma
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REAL-WORLD EFFECTIVENESS OF UPADACITINIB ACROSS DIFFERENT CLINICAL PHENOTYPES IN A LARGE ITALIAN PSA COHORT
No full textRelationship Between Gender Essentialism and System-Justifying Beliefs: A Meta-Analysis
No full textGender inequality remains a significant social issue, disproportionately impacting cisgender and heterosexual women as well as lesbian, gay, bisexual, transgender, queer, intersex, asexual plus individuals. This meta-analysis aims to investigate the relationship between gender essentialism-a belief that views gender as biologically determined and immutable-and system-justifying beliefs (SJB) that sustain and legitimize existing social order. A four-level meta-analysis of 51 studies was conducted, comprising 118 samples and 327 effect sizes, with a total of 29,252 participants (sample sizes ranging from 21 to 2,803, 40% cisgender men, mean age of 29.52 years). Results revealed a moderately strong, significant, and positive association between gender essentialism and SJB, Zr = 0.391, SE = 0.029, t(326) = 13.499, p < .0001, 95% confidence interval (CI) [0.334, 0.448]. This relationship was not significantly moderated by the participant's group status (majority vs. minority) but was influenced by the type of SJB considered and the target of gender essentialism. Specifically, gender essentialist beliefs were more strongly related to justifications of gender asymmetry (e.g., sexism, heterosexism) than to general hierarchical attitudes (e.g., social dominance orientation). Additionally, this association was stronger for essentialism of marginalized individuals (e.g., transgender individuals and people with diverse gender identities) compared to relatively privileged groups (e.g., cisgender and heterosexual people). These findings suggest that gender essentialism may help both majority and minority groups to rationalize existing inequalities. This highlights the need for future research to focus on the social construction of gender to mitigate its impact on marginalized groups and reduce the reinforcement of social inequalities
Morita−Baylis−Hillman Adduct Chemistry as a Tool for the Design of Lysine-Targeted Covalent Ligands
No full textThe use of Targeted Covalent Inhibitors (TCIs) is an expanding strategy for the development of innovative drugs. It is driven by two fundamental steps: (1) recognition of the target site by the molecule and (2) establishment of the covalent interaction by its reactive group. The development of new TCIs depends on the development of new warheads. Here, we propose the use of Morita-Baylis-Hillman adducts (MBHAs) to covalently bind Lys strategically placed inside a lipophilic pocket. A human cellular retinoic acid binding protein II mutant (M2) was selected as a test bench for a library of 19 MBHAs. The noncovalent interaction step was investigated by molecular docking studies, while experimentally the entire library was incubated with M2 and crystallized to confirm covalent binding with the target lysine. The results, rationalized through covalent docking analysis, support our hypothesis of MBHAs as reactive scaffolds for the design of lysine-TCIs
How does the transition from an indoor feeding system to part- time grazing affect dairy cow performance in northern latitudes?
No full textIntraoperative nerve monitoring in thyroid and parathyroid surgery: a decade of Italian practice
No full textIntraoperative nerve monitoring (IONM) has been recognized as a useful adjunct into the field of thyroid and parathyroid surgery, aiding in the accurate identification and preservation of the recurrent laryngeal nerve (RLN), consequently reducing the probability of nerve injury and promoting surgical safety. This investigation seeks to amplify the findings of a similar nationwide survey performed in 2014 by offering an updated assessment of IONM practices among Italian surgical institutions, reflecting a decade of advancements and transformations in clinical approaches. A comprehensive nationwide survey was implemented targeting Italian endocrine surgeons to assess the prevalence, utilization patterns, attitudes and perceptions surrounding IONM in the context of thyroid and parathyroid surgical procedures. Structured questionnaires were administered to seventy endocrine surgery centers, and the resulting data were evaluated employing both quantitative and qualitative analysis methods. The survey disclosed that 67.14% of the participants confirmed the routine deployment of IONM across all cervical surgical procedures, particularly in high-risk contexts. Relative to the findings from 2014, a marked rise in the implementation of IONM has been recorded; however, variability persists, especially between continuous and intermittent monitoring strategies. Surgeons recognized improved surgical safety, decreased complication frequencies, and educational advantages as significant key drivers for the incorporation of IONM. Nonetheless, issues, such as false-positive and false-negative results, along with the lack of standardized protocols, remain barriers to its uniform application. During the past ten years, IONM has been thoroughly adopted by Italian endocrine surgeons as a result of its critical contribution to the improvement of surgical outcomes and the provision of educational resources. However, the results highlight the imperative for further standardization of protocols, the advancement of training programs, and the resolution of reimbursement obstacles to ensure equitable and consistent application of IONM across Italian centers, ultimately optimizing patient care
The recipe similarity network: a new algorithm to extract relevant information from cookbooks
No full textDrugs as contaminants of emerging concern: preventive approaches beyond detection, regulatory aspects and remediation
No full textAn analytical and machine learning approach for total mercury and methylmercury determination in squid: enhancing food safety testing and traceability monitoring systems
No full textThis study presents the first assessment of total mercury (THg) and methylmercury (MeHg) in squids (Todarodes sagittatus, L.), providing insights into contamination levels and their correlation with the geographical origin. A method based on acidic extraction of THg, re-extraction of MeHg into toluene, and back-extraction into L-cysteine, followed by direct mercury analysis, was refined through a robust multivariate optimization scheme using a fractional factorial design. This approach improved efficiency by reducing sample mass and analysis time, while ensuring high accuracy, precision, and sensitivity. The method quickly confirmed higher median MeHg levels in Mediterranean than in Atlantic squids (1.00 vs. 0.051 mg kg−1), and a higher MeHg/THg ratio in Atlantic samples (84 % vs. 72 %). Support vector machine classification based on principal component analysis scores from THg and MeHg data successfully differentiated squid samples by provenance (AUC = 1). This cost-effective workflow enhances mercury monitoring while ensuring safety and traceability with minimal resource requirements
Correction to: Innovative Technologies for Smarter and Efficient Operating Room Scheduling (Journal of Medical Systems, (2025), 49, 1, (37), 10.1007/s10916-025-02168-1)
No full textThe online PDF version of this article contained mistake and the author would like to correct it. The last paragraph and reference lists were missing in the published online PDF version. The original article has been corrected
Simultaneous optical phase and loss estimation revisited : measurement and probe incompatibility
No full textQuantum multiparameter metrology is hindered by incompatibility issues, such as finding a single probe state (probe incompatibility) and a single measurement (measurement incompatibility) optimal for all parameters. The simultaneous estimation of phase shift and loss in a single optical mode is a paradigmatic multiparameter metrological problem in which such tradeoffs are present. We consider two settings: single-mode or two-mode probes (with a reference lossless mode), and for each setting we consider either Gaussian states or arbitrary quantum states of light restricted only by a maximal number of photons allowed. We find numerically that, as the number of photons increases, there are quantum states of light for which probe incompatibility disappears both in the single- and two-mode scenarios. On the other hand, for Gaussian states, probe incompatibility is present in the single-mode case and may be removed only in the two-mode setting thanks to the entanglement with the reference mode. Finally, we provide strong arguments that the fundamental incompatibility aspect of the model is measurement incompatibility, which persists for all the scenarios considered, and unlike probe-incompatibility cannot be overcome even in the large photon number limit