Archivio istituzionale della Ricerca - Università degli Studi di Parma
Not a member yet
127980 research outputs found
Sort by
Il rilievo del pacchetto Omnibus (di emendamenti alla CSRD e alla CSDDD) per le catene del valore
No full textIl contributo analizza il rilievo delle modifiche proposte dal “pacchetto Omnibus I” (COM
(2025) 81 final 2025/0045 -COD) della Commissione europea per le catene del valore. Le
proposte potrebbero introdurre minori oneri e costi di compliance per le imprese obbligate e
minori ripercussioni sulle imprese non obbligate ma facenti parte della catena del valore
delle prime. Tuttavia, l’indeterminatezza terminologica di alcune modifiche è suscettibile di
creare questioni interpretative. Inoltre, il minor impatto delle modifiche sulla responsabilità
delle imprese obbligate, specialmente nell’ambito della CSDDD, non può che suscitare una
riflessione più generale sul ridimensionamento degli obiettivi perseguiti dal legislatore
rispetto alla rilevazione di eventuali impatti negativi lungo la catena del valore delle imprese.The paper analyzes the significance of the proposed changes introduced by the European
Commission’s “Omnibus package I” (COM (2025) 81 final 2025/0045 -COD) for value
chains. The proposals could lead to reduced burdens and compliance costs for obligated
companies, as well as fewer trickle-down effects for non-obligated companies that are
nonetheless part of the value chains. However, the vagueness of the wording of certain
amendments is likely to give rise to interpretative issues. Moreover, the reduced impact of the
changes on the liability of obligated companies—particularly within the scope of the
CSDDD—inevitably raises a wider discussion on the downscaling of the objectives pursued
by the legislator concerning the identification of potential negative impacts along corporate
value chains
Diagnosi microclimatica dello spazio aperto. Metodi e strumenti per la rigenerazione dello spazio tra gli edifici
No full textIl volume vuole analizzare le molteplici questioni legate allo spazio aperto
(detto anche “vuoto”) sia nella città storica che in quella contemporanea,
affrontando una tematica spesso sottovalutata ma, che a causa degli
evidenti cambiamenti climatici e della necessità di rigenerare gli spazi
urbani esistenti, assume un ruolo fondamentale per cittadini, progettisti e
amministratori. La trattazione spazia dalle esigenze di conservazione e di
rispetto dell’esistente, integrando strategie già note con nuovi paradigmi
ambientali e rigenerativi, al fine di coniugare istanze di tipo energetico e di
comfort termico, tramite un approccio analitico-prestazionale. Le riflessioni
proposte mettono al centro della trattazione la diagnosi microclimatica,
che per la prima volta, viene assunta come strumento conoscitivo per
l’analisi e strumento operativo per la fase di valorizzazione dello spazio
aperto tra gli edifici. Il volume raccoglie una rassegna di casi esemplari
in cui le valutazioni numeriche microclimatiche, eseguite ex ante ed ex
post per la rigenerazione dello spazio vuoto, sono presentate e discusse,
rispetto a differenti tipologie di spazio aperto
Endotension following endovascular aortic repair: systematic review and meta-analysis on occurrence rate, treatment approaches and outcomes
No full textINTRODUCTION: Endotension is still a poorly understood phenomenon in terms of occurrence rate, treatment indications and outcomes. The aim of this study was to report incidence, different treatment approaches and outcomes of patients affected by endotension after EVAR. EVIDENCE AQUISITION: A systematic review of the literature (database searched: PubMed, Web of Science, Scopus, Cochrane Library) was undertaken until June 2024. Articles reporting data about occurrence rate, strategy of treatment and outcomes of patients affected by endotension, including at least five cases of endotension were included. Meta-analyses of proportions were performed using a random-effects model. EVIDENCE SYNTHESIS: Thirteen non-randomized studies published between 2005 and 2024 were examined, with a total of 22,118 patients undergoing EVAR due to abdominal aortic aneurysm. Among them, 209 patients developed endotension during follow-up, resulting in an estimated occurrence rate of 1.6% (95% CI 0.9-2.3). Four approaches to treat endotension were reported in literature. Estimated rates were: open surgical conversion (OSC) in 37.3% (95% CI 10.5-64.0), conservative approach in 25.9% (95% CI -4.4-56.2), endovascular relining in 23.3% (95% CI 11.4-35.2) and semi-conversions in 19.5% (95% CI 4.9-34.2). The technical success (TS) in OSC, relining and semi-conversion subgroups were respectively: 93.4% (95% CI 85.7-101), 80.7% (95% CI 60.5-101) and 94.5% (95% CI 85.2-103.8). CONCLUSIONS: OSC is the most used method, achieving high TS rate. OSC and semi-conversion presented a high CS during follow-up, while relining had lower "durability" compared to surgical treatments. Data about conservative treatment are scarce but in can be considered for selected cases
Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes
No full textHuman lifespan is shaped by genetic and environmental factors. To enable precision health, understanding how genetic variants influence mortality is essential. We conducted a survival analysis in European ancestry participants of the UK Biobank, using age-at-death (N=35,551) and last-known-age (N=358,282). The associations identified were predominantly driven by cancer. We found lifespan-associated loci (APOE, ZSCAN23) for common variants and six genes where burden of loss-of-function variants were linked to reduced lifespan (TET2, ATM, BRCA2, CKMT1B, BRCA1, ASXL1). Additionally, eight genes with pathogenic missense variants were associated with reduced lifespan (DNMT3A, SF3B1, TET2, PTEN, SOX21, TP53, SRSF2, RLIM). Many of these genes are involved in oncogenic pathways and clonal hematopoiesis. Our findings highlight the importance of understanding genetic factors driving the most prevalent causes of mortality at a population level, highlighting the potential of early genetic testing to identify germline and somatic variants increasing one’s susceptibility to cancer and/or early death
Cancer mortality predictions for 2025 in Latin America with focus on prostate cancer
No full textWe provided cancer mortality rate estimates for the year 2025 in six Latin American countries (Argentina, Brazil, Chile, Colombia, Cuba, and Mexico), focusing on prostate cancer. We extracted mortality data for all cancers combined and the most common sites from the WHO and population data since 1970 from the United Nations. Estimates for 2025 were computed applying a linear regression to the most recent segment identified through Poisson join-point regression. Avoided deaths number from 1991 to 2025 was estimated by applying the 1990 peak rate to population data. Mortality from all cancers is predicted to be favorable for both sexes in all countries. The lowest total cancer mortality rates are expected in Mexico (67.7/100 000 males; 61.4/100 000 females), while the highest ones in Cuba (136.6/100 000 males; 91.6/100 000 females). Prostate cancer mortality is declining in all countries, although rates remain high in Cuba (25.2/100 000 in 2025). Downward patterns are observed for all age groups in all countries, except the elderly in Cuba and Mexico. Declines in mortality are predicted for colorectal (except for males in Brazil and Cuba, and females in Chile), stomach (except Cuban males), pancreatic (except Argentinian and Cuban males), lung, bladder (except Argentinian females), breast, and ovarian (except Cuba) cancers. Uterine cancer mortality, particularly from cervical cancer, remains highin Argentina (10.2/100 000) and Cuba (10.4/100 000). Except for uterine, stomach, and prostate cancers, cancer mortality rates are still relatively low in Latin America, except Cuba. Controlling tobacco particularly in Cuba, implementing organized cervical cancer screening, and advancing cancer treatment also for prostate cancer remain crucial in all countries considered
Correction to: Identification of the hydrogeochemical processes and assessment of groundwater quality using Water Quality Index (WQI) in semi-arid area F'kirina plain eastern Algeria (Environmental Earth Sciences, (2024), 83, 22, (626), 10.1007/s12665-024-11917-3)
No full textValidity and reliability of patient activation measure (PAM13-I) Italian version among patient undergoing elective surgery
No full textThe patient activation measure (PAM), a recognized measure of how active patients are in their care, is one of the most extensively used, widely translated, and tested instruments worldwide in measuring patient activation. This study aimed to assess the psychometric properties and construct validity of the Italian version of the 13-item Patient Activation Measure (PAM13-I) among patients undergoing elective laparoscopic cholecystectomy. A multicenter study was conducted across 111 surgical units in Italy. This study involved the preoperative administration of the PAM questionnaire to 4532 patients. The psychometric properties of the PAM were evaluated using Rasch analysis. The PAM13-I demonstrated good internal consistency (Cronbach's α = 0.95) and reliability indices. While fit statistics were acceptable, ceiling effects were observed. No significant differential item functioning was found. However, issues with targeting and local response dependency were identified. The Italian PAM-13 showed promising psychometric properties among surgical patients, indicating its potential utility in assessing patient activation. However, concerns regarding ceiling effects and targeting suggest the need for further refinement and validation in surgical populations
