Archivio istituzionale della Ricerca - Università degli Studi di Parma
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L’utilizzo dell’accesso intraosseo in pazienti clinicamente deteriorati ricoverati in reparti di degenza ordinaria: protocollo di una scoping review
No full textMechanical Behaviour of Multiple Cracked Nanobeams: A Novel Analytical Model
No full textThe aim of the present paper is to propose a novel nonlocal analytical model to investigate the mechanical behaviour of a multiple cracked nanobeam subjected to bending load. Such a model is a reformulation of that proposed by some of the present authors for a single cracked nanobeam, and exploits the Stress Driven nonlocal Model within the Euler-Bernoulli beam theory. According to such a novel formulation, the nanobeam is split in correspondence of each of the n cracks, thus obtaining n+1 segments connected to each other by means of massless elastic rotational springs. The stiffness of each spring is computed by using firstly the Griffith's energy criterion and then the conventional Linear Elastic Fracture Mechanics, where the stress intensity factor is computed through a finite element modelling. The proposed model is employed to simulate a bending test performed on a cantilever microbeam containing two edge-cracks, and a parametric study is performed by varying the depths of the cracks, their reciprocal distance and the position of the first crack in order to explore how such parameters influence the mechanical response of the above microbeam
ARIA–Italy managing allergic rhinitis and asthma in a changing world: The role of the Pharmacist
No full textAllergic rhinitis (AR) and asthma are common respiratory disorders that often occur together, affecting quality of life and increasing healthcare expenses of patients. These chronic illnesses are often managed without medical supervision, creating distinct challenges. A lack of resources can limit regular follow-up, which in turn promotes disease mismanagement and an increased reliance on self-medication, including the inappropriate use of corticosteroids and nasal decongestants. Community pharmacies could serve as critical primary healthcare providers, facilitating AR and asthma management by promoting therapy adherence, minimizing drug misuse, and improving symptom monitoring using digital tools. The evolving role of pharmacists as vital healthcare team members is highlighted by their involvement in screening, prevention, and patient education, particularly in underserved communities. Strengthening the partnerships between pharmacists, physicians, and patients may lead to more tailored and effective management strategies. This collaborative approach has demonstrated promise in enhancing disease outcomes and reducing healthcare costs
Simultaneous bilateral robotic-assisted partial nephrectomy using a dual stepwise transperitoneal and retroperitoneal approaches: A case report
No full textTrustworthy and human-centric? The new governance of workplace AI technologies under the EU’s Artificial Intelligence Act
No full textScoliosis in spinal muscular atrophy in the era of disease-modifying therapy: a scoping review
No full text: Spinal muscular atrophy (SMA) frequently causes scoliosis (up to 90% of cases), due to weakened axial muscles impacting motor and respiratory function. While new SMA treatments improve motor function, their effect on scoliosis progression is unclear. This scoping review (2016-October 2024) analyzed literature from Pubmed, MEDLINE, EMBASE, and Scopus, focusing on studies of SMA, scoliosis, and treatment approaches. The aim of this work was to describe the clinical features and the possible therapeutic approaches of scoliosis in the "new population" of pharmacologically treated SMA patients. We included all types of SMA as well as all the approved disease modifying therapies (DMTs). The review found significant variability in scoliosis presentation and surgical intervention among different types of treated SMA patients. Early pharmacological treatment may slow scoliosis progression, particularly in Type II SMA. Interestingly, Type I SMA patients, who typically don't develop scoliosis due to severe hypotonia, showed an increased scoliosis onset. Larger studies are needed to fully evaluate the impact of different treatments on scoliosis progression in SMA, especially in Type I SMA patients, to establish updated standards of care
Understanding the interaction between melatonin and bifidobacteria
No full textAim: The human gastrointestinal tract is home to a complex and dynamic microbial community, known as the gut microbiota, which begins to form at birth and evolves throughout life. Among the factors influencing its initial development, breastfeeding is one of the most important. Human milk is a chemically complex body fluid, including hormones, like melatonin, which is involved in regulating the sleep-wake cycle, helping to establish the newborn's circadian rhythm. In the current study, the molecular interactions between human melatonin and a bifidobacteriarich infant gut microbiota were explored. Methods: Possible molecular communication was assessed using in vitro assays and functional genomic approaches. Results: Our results highlight that melatonin elicits different functional microbial impacts, both at transcriptional and phenotypic levels (i.e., adhesion to intestinal cells), that are dependent on the bifidobacterial species analyzed. Conclusion: Among the bifidobacterial taxa assayed, Bifidobacterium bifidum demonstrated the highest level of molecular interaction with melatonin, highlighting its significant role in this process
Author Correction: Two decades of occurrence of non-pathogenic rabbit lagoviruses in Italy and their genomic characterization (Scientific Reports, (2024), 14, 1, (29234), 10.1038/s41598-024-79670-y)
No full textRedox-driven photoselective self-assembly
No full text: Self-assembly via non-covalent interactions is key to constructing complex architectures with advanced functionalities. A noncovalent synthetic chemistry approach, akin to organic chemistry, allows stepwise construction with enhanced control. Here, we explore this by coupling Pt(II) complex self-assembly with a redox reaction. Oxidation to Pt(IV) creates a non-emissive monomer that, upon reduction to Pt(II), forms luminescent gels with unique kinetic and thermodynamic pathways. UV irradiation induces Pt(IV) reduction, generating supramolecular fibers with Pt∙∙∙Pt interactions, enhancing photophysical properties and enabling visible light absorption up to 550 nm. This allows photoselective growth, where fibers convert surrounding Pt(IV) to Pt(II), promoting growth over nucleation, as observed via real-time fluorescence microscopy