Archivio istituzionale della Ricerca - Università degli Studi di Parma
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Omologazione e disposizioni sulla liquidazione nel concordato liquidatorio e in continuità
No full textTherapeutic effect of cyclosporine A-loading TPGS micelles on a mouse model of LPS-induced neuroinflammation
No full textNeuroinflammation is an undoubted hallmark of neurodegenerative processes characterized by memory impairment, loss of coordination and muscle strength in diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis as well as depressive disorders. Cyclosporine A (CSA) has already been identified as a promising neuroprotective peptide, due to its well-known anti-inflammatory properties. Herein, CSA was encapsulated into α-tocopherol polyethylene glycol 1000 succinate (TPGS) micelles and intranasally administered to a lipopolysaccharide (LPS) induced mouse model of neuroinflammation. After the treatment, mice were subjected to behavioral tests to assess cognitive and motor skills, while the biodistribution of CSA in plasma and olfactory bulb was studied by a new HPLC method validated for precision and accuracy. The results highlighted that in comparison to the classic oral CSA suspension, the intranasal (IN) administration showed significatively better safety and efficiency profiles. Notably, IN administration of CSA micelles showed relevant antidepressive effects and a certain ability to revert LPS-induced motor impairment. This work pointed out that the innovative and noninvasive IN administration of TPGS micelles could represent a safe and effective alternative to the classic oral route to deliver CSA at the Central Nervous System level, where its beneficial activity against neuroinflammation can be exploited
Interprofessional collaboration in acute care settings: qualitative research among nurses and radiographers
No full textBackground: Interprofessional collaboration (IPC) not only benefits the multiprofessional team, but also has the potential to improve patient outcomes. Understanding the roles of health professional colleagues can lay a strong foundation for IPC, particularly in settings where timely procedures are crucial. Aims.: This study aimed to analyse perceptions of IPC among nurses and radiographers working in acute care settings. Methods: A descriptive qualitative study involving online focus groups of nurses and radiographers working in acute care. The data collected were analysed through thematic analysis. Findings: Four dimensions emerged from the analysis - organisational dimension, cognitive dimension, individual dimension and relational. Each represented a well-defined area and could be divided further into subthemes. Conclusion: The four dimensions influence IPC among nurses and radiographers in acute care. Improving the factors identified and implementing changes can have a positive impact on patients' quality of care
Exploring spectral and phylogenetic diversity links with functional structure of aquatic plant communities
No full textAs freshwater ecosystems are threatened globally, the conservation of aquatic plant diversity is becoming a priority. In the last decade, remote sensing has opened up new opportunities to measure biodiversity, especially across terrestrial biomes, and the combination of spectral features with additional information derived from community phylogeny can further advance the accurate characterisation of plant functional diversity across scales. In this study, we explored the use of spectral features extracted from centimetre resolution hyperspectral imagery collected by a drone and phylogenetic metrics derived from a fully resolved supertree to estimate functional diversity (richness, divergence, and evenness) using non-linear parametric and machine learning models within communities of floating hydrophytes and helophytes sampled from different sites. Our results show that all three functional diversity metrics can be estimated from spectral features using machine learning models (random forest; R2 = 0.90–0.92), while parametric models perform worse (generalised additive models; R2 = 0.40–0.79), especially for community evenness. Merging phylogenetic and spectral features improves modelling performance for functional richness and divergence (R2 = 0.95–0.96) using machine learning, but only significantly benefits community evenness estimation when parametric models are used. The combination of imaging spectroscopy and phylogenetic analysis can provide a quantitative way to capture variability in plant communities across scales and gradients, to the benefit of ecologists focused on the study and monitoring of biodiversity and related processes
Romanie emergenti. Costruzione di spazi “familiari” tra Est ed Ovest europei
No full textBasandosi su una etnografia multisituata di lungo periodo, prevalentemente tra l’Italia e la Romania, ma anche in Inghilterra e Francia, questo contributo esplora mobilità interconnesse attraverso genealogie e legami parentali, connettendo, dunque, direttamente la mobilità all’organizzazione sociale. Ci soffermeremo sugli intrecci fra geografie fisiche, sociali, culturali ed emotive attraverso la dinamicità delle reti parentali di un network di famiglie di rudari romeni, riflettendo sulle pratiche e il senso delle (im)mobilità interconnesse e delle loro stratificazioni. Troveremo, quindi, l’emersione di differenti e intrecciate “Romanie” (nel passato e nel presente) così come anche la costruzione-decostruzione-ricostruzione di plurimi confini che contribuiscono a fare e disfare continuamente un “est” e un “ovest”, e che declineremo attraverso le esperienze, appartenenze e trasformazioni dei “nostri” rudari.
Based on a long-term multi-sited ethnography, mainly curried out between Italy and Romania, but also in England and France, this article explores interconnected mobilities through genealogies and kinship ties, thus directly connecting mobility to social organization. We will focus on the intertwining of physical, social, cultural and emotional geographies through the dynamism of the kinship networks of Romanian rudari families, reflecting on practices and sense of interconnected (im)mobilities and their stratifications. We will therefore find the emergence of different and intertwined "Romanias" (in the past and in the present) as well as the construction-deconstruction-reconstruction of multiple borders/boundaries that contribute to continuously making and undoing an "East" and a "West", and with whom we deal through experiences, belongings and transformations of "our" rudari
From Industry 4.0 to Industry 5.0: Opportunities, Challenges, and Future Perspectives in Logistics
No full textIndustry 4.0 and Industry 5.0 bring opportunities and challenges to logistics, leveraging technologies such as Internet of Things, Artificial Intelligence and big data and focusing on human-centered, resilient and sustainable systems. It is essential to clarify the interplay between Industry 4.0 and 5.0 and their implications for logistics 4.0 and logistics 5.0. This study presents descriptive and bibliometric analyses of articles retrieved from the Scopus database and focusing on the topics mentioned just above. The results shows that companies achieve significant improvements in traceability, and customer satisfaction with Industry 4.0 technologies. Industry 5.0 builds on this foundation, emphasizing human-technology integration. Thus, the study demonstrates that the integration of these two industrial revolutions is crucial for enhancing operational efficiency and significantly improving all aspects of logistics processes. Finally, the study emphasizes the importance of environmental sustainability and suggests areas for future research, such as ergonomics and human factors, to better integrate emerging technologies with the capabilities and requirements of operators
Sleep quality among Italian university students: the UnSleep multicenter study
No full textBackground: Scientific evidence demonstrates that poor sleep quality can lead to various health problems. This study aimed to investigate sleep patterns among Italian university students and identify several factors that may contribute to its quality. Study design: Cross-sectional study. Methods: An electronic questionnaire regarding sociodemographic characteristics, lifestyle, and sleep-related habits, including the Pittsburgh Sleep Quality Index (PSQI) questionnaire, was distributed between January 2022 and July 2023 among students belonging to 12 universities located in Northern, Central, and Southern Italy. Results: On a total of 1,674 questionnaires collected, the participants (mean age 24.06±4.56 years, 71.3% F) reported an average number of hours of nocturnal sleep equal to 6.89±1.28 hours. A total of 927 (54.6%) of respondents showed a poor sleep quality (PSQI >5). Regression analysis showed that better sleep quality is associated with lower age, attending universities in Northern Italy, less time spent on electronic devices during the day, not being used to study at night and not playing videogames before sleep. Conclusion: From a public health perspective, our findings suggest that public health operators should raise the awareness of young adults about the importance of sleep quality for maintaining good health, as well as the impact that certain behaviors can have on sleep
Conformal Geometry of Quasi-Umbilical Timelike Surfaces
No full textThe paper focuses on the conformal Lorentz geometry of quasi-umbilical timelike surfaces in the (1+2)-Einstein universe, the conformal compactification of Minkowski 3-space realized as the space of oriented null lines through the origin of R^{2,3}. A timelike immersion of a surface X in the Einstein universe is quasi-umbilical if its shape operator at any point of X is non-diagonalizable over C. We prove that quasi-umbilical surfaces are isothermic, that their conformal deformations depend on one arbitrary function in one variable, and show that their conformal Gauss map is harmonic. We investigate their geometric structure and show how to construct all quasi-umbilical surfaces from null curves in the 4-dimensional neutral space form