Archivio Istituzionale della Ricerca- Università del Salento
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Devices and techniques for bariatric and metabolic endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Technical and Technology Review
No full text: Endoscopic bariatric and metabolic therapies (EBMTs) are increasingly recognized as valuable tools for managing obesity and related metabolic disorders. As the prevalence of obesity continues to rise globally, there is a growing demand for effective, safe, and less invasive treatment options. This review provides a comprehensive summary of the available EBMTs, including both stomach-targeted and small-bowel-targeted devices. The review details the various devices, outlines the techniques for their proper use, and discusses their indications. It also presents data on their efficacy and safety, and the management of adverse events and weight regain, as well as anticipated future developments. The paper emphasizes the necessity for additional high quality randomized controlled trials and long-term outcome data to better define the role of these therapies within obesity treatment protocols. Overall, this review serves as an authoritative resource for endoscopists, bariatric specialists, and the wider healthcare community involved in obesity care, promoting best practices and guiding the appropriate implementation of EBMTs in clinical settings
Direct Evidence of the Presence of Hybrid Charge Transfer State in a Perovskite Nanocrystal‐Polythiophene Blend Solid State Film
Full text linkIn this paper, the photophysical properties of a hybrid material, composed of a conjugated polymer and perovskite nanocrystals, are investigated by ultrafast spectroscopy and morphological characterization. The relaxation dynamics of a drop-casted film from the semiconducting polythiophene (P3HT) and a green-emitting CsPbBr3 (zwitterionic sulfobetaine -capped) perovskite nanocrystals (NCs) solution is studied. The transient spectroscopy presents a very long photobleaching signal peaked at 516 nm not present in the single components of the blend. The scanning electron and confocal fluorescence microscopy images show that the P3HT and the CsPbBr3 NCs are finely mixed in the film. The presence of a very efficient hole transfer from the nanocrystal to the polymeric chain that induces the formation of a long -lived charge-transfer state as shown in the pump-probe measurements is proposed. The theoretical model reveals the important role of the zwitterionic sulfobetaine capper in this process. The perovskite strongly adsorbs the surfactant, while the polythiophene chain is not directly bound to the perovskite. Instead, it interacts with the surfactant itself, contributing to the electronic properties of the overall system
Large Eddy Simulations of a rotating propeller in an equilibrium scour hole
No full textPropeller-induced scour hole is one of the most fascinating present-day topics. First laboratory tests back years ago were in still water (SW) simulating harbour conditions, whereas less attention was paid to the influence of a flow impacting the propeller, which is a typical condition in navigable channels. In this work, two laboratory tests, carried out in the Laboratorio “Grandi Modelli Idraulici”, Università della Calabria, in a rectangular cross-section tilting flume, are presented. In both tests a propeller rotated close to an erodible bed compound by uniform sand, since a local scour hole at the equilibrium state was achieved. The former test was carried out in the canonical SW condition as a reference for the latter test, which presented a flow impacting the rotating propeller. Once the equilibrium scoured bathymetry was reached, punctual velocity measurements were acquired with the Acoustic Doppler Velocimetry. Finally, the flume bed was slowly drained by bottom sinks and scanned using a high-resolution photogrammetry technique. Punctual velocity measurements were used to validate the highly complex flow of the propeller jet in both SW and running flow impacting the propeller. The numerical simulation (NS) of the flow field was performed by means of the filtered unsteady Navier-Stokes equations for incompressible fluids in three dimensions and conservative form. In the framework of the Large Eddy Simulation (LES) approach, the scales smaller than the grid size were accounted in the Sub-Grid Scale (SGS) tensor through the Wall-Adapting Local Eddy (WALE) viscosity model (Nicoud & Ducros, 1999). The LES governing equations were discretized by means of the Finite Volume Method (FVM). The NS were performed using the pimpleDyMFoam solver, embedded in the OpenFOAM C++ libraries. The pimpleDyMFoam is designed to solve the incompressible, turbulent flow on a moving mesh using the Arbitrary Mesh Interface (AMI) method, handling mesh rotating movements (Aguerre et al., 2017). This solver uses the pressure implicit method for the pressure-linked equations algorithm (Jasak, 1999). The NS aims at the velocity field comparison between the propeller jet joint to the channel flow and the SW conditions. Moreover, low and high-order moments were computed to highlight the difference generated by the impact of the upstream flow
Biological Barrier Models-on-Chips: A Novel Tool for Disease Research and Drug Discovery
Full text linkThe development of alternatives to animal models and traditional cell cultures has led to the emergence of organ-on-chip (OoC) systems, which replicate organ functions under both physiological and pathological conditions. These microfluidic platforms simulate key tissue interfaces—such as tissue–air, tissue–liquid, and tissue–tissue interactions—while incorporating biomechanical stimuli to closely resemble in vivo environments. This makes OoC systems particularly suitable for modeling biological barriers such as the skin, the placenta, and the blood–brain barrier, which play essential roles in maintaining homeostasis. This review explores various biological barrier models that can be replicated using the OoC technology, discussing the integration of induced pluripotent stem cells (iPSCs) to advance personalized medicine. Additionally, we examine the methods for assessing barrier formation, including real-time monitoring through integrated sensors, and discuss the advantages and challenges associated with these technologies. The potential of OoC systems in disease modeling, drug discovery, and personalized therapeutic strategies is also highlighted
Translating Patent Innovation into Clinical Practice: Two Decades of Therapeutic Advancements in Dysbiosis Management
No full textLa friche nostrana
Full text linkL'autore riflette sull'importanza dei luoghi incolti per l'ambiente e la biodiversità, specialmente nel contesto climatico attuale, nel quale la Terra risponde con violenza all'inquinamento e allo sfruttamento indiscriminato delle risorse causati dall'azione degli uomini
Migrare come Abitare: verso la ricomposizione di un paradigma?
Full text linkIl saggio indaga la possibilità di ridefinire la migrazione attraverso la categoria dell’abitare, superando la
contrapposizione tra mobilità e sedentarietà. A partire dalla necessità di ricomporre il paradigma giuridico e
politico della migrazione, si rivaluta lo ius migrandi e il concetto vatteliano di habitant perpétuel, esplorando il rapporto tra erranza e nuovo ordine mondiale. L’analisi si concentra sulle trasformazioni dello spazio come processo dinamico, in cui territorializzazioni, pratiche generative e segregazione abitativa si intrecciano. Attraverso la prospettiva della contextual diversity, si propone un ripensamento dello spazio non solo come luogo o flusso, ma come rete di relazioni, ridefinendo così il senso stesso dell’abitare nel mondo contemporaneo
La frontiera tra il Regno di Sicilia (Napoli) e lo Stato della Chiesa. Alcune riflessioni
Full text linkThe frontier between the Kingdom of Sicily and the Papal territories was definitively established with the Pact of Benevento signed in 1156 by Pope Adrian IV and King William I, confirming the division of the ancient imperial territories of the Duchy of Spoleto. To the south of the border the demarcation was based on the diocesan borders established starting from the Carolingian era. To the north an arbitrary line was im posed by political and military powers, corresponding neither to ancient demarcations nor to regional history. The creation of the border changed the geopolitical structure of centralsouthern Italy and was an object of particular interest to kings and popes. Dur ing the twelfth century some border areas such as Rieti, Terracina, Anagni, Benevento, Antrodoco and Tagliacozzo acquired a special role and prestige they could not otherwise have obtained. On the negative side, the border was a stage for nearly constant warfare. In conclusion, the Norman era laid the foundations for what sources in the following century described as one of the best guarded and administered borders of the Middle Ages
Tutela penale e libertà morale: rapsodiche riflessioni in prospettiva de lege ferenda
No full textNel contributo ci si sofferma sulla disciplina codicistica relativa ai delitti contro la libertà morale e si analizzano, in particolare, le fattispecie della violenza privata e degli atti persecutori, evidenziandone le più rilevanti criticità e proponendo talune modifiche in prospettiva de lege ferenda. Ci si sofferma poi sul fenomeno del c.d. mobbing e sulla questione della sua rilevanza penale de lege lata e ci si interroga sull'opportunità dell'introduzione di una norma incriminatrice ad hoc