Archivio Istituzionale della Ricerca- Università del Salento
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Endoscopic Full Thickness Resection Device (FTRD®) for the Management of Gastrointestinal Lesions: Current Evidence and Future Perspectives
No full text: Endoscopic full-thickness resection (EFTR) has emerged as a transformative technique for managing gastrointestinal (GI) lesions, previously deemed unsuitable for endoscopic removal. Unlike conventional endoscopic resection methods, such as endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), EFTR enables en bloc excision of both intraluminal and subepithelial lesions by resecting all layers of the GI wall, followed by defect closure to prevent complications. The introduction of the full-thickness resection device (FTRD®) has significantly enhanced the feasibility and safety of EFTR, particularly in the colon and upper GI tract, with increasing adoption worldwide. This review provides a comprehensive analysis of FTRD®, focusing on its clinical applications, procedural methodology, and comparative efficacy against other endoscopic resection techniques. The indications and contraindications for EFTR are explored, highlighting its utility in treating non-lifting adenomas, subepithelial tumours, and T1 carcinomas without lymph node involvement. This review synthesizes current clinical data and FTRD® advantages. Despite its strengths, EFTR via FTRD® incorporates challenges such as limitations in lesion size, procedural complexity, and potential adverse events. Strategies for overcoming these challenges, including hybrid techniques and modifications in procedural approach, are examined. The review also emphasizes the need for further research to optimize surveillance strategies and determine the long-term clinical impact of EFTR in GI lesion management. By integrating recent evidence, this paper provides valuable insights into the evolving role of EFTR in therapeutic endoscopy
Cleopatra: a 12-channel recycling integrator ASIC for the readout of hydrogenated amorphous silicon detectors in radiotherapy dosimetry
Get PDFThe Cleopatra ASIC is a 12-channel prototype ASIC for the readout of hydrogenated amorphous silicon sensors used for real-time dosimetry in radiation diagnostic and radiation therapy. The architecture is based on a current to frequency conversion based on the recycling integrator principle in order to cover a dynamic range of four orders of magnitude with high linearity. Three different input amplifier configurations have been implemented in order to check the trade-off between detector capacitance and maximum output frequency. Cleopatra has been designed in CMOS 28 nm technology and succesfully tested in laboratory
Zur Ambiguität von dadaistischen Titeln: Am Beispiel von Kurt Schwitters’ "An Anna Blume"
No full textFür die Erforschung der literarischen "ambiguitas" erweisen sich die Texte der experimentierfreudigen Dichter aus der Dada-Bewegung als äußerst relevant. Insbesondere kann das Gedicht "An Anna Blume" vom Merzkünstler Kurt Schwitters als Manifest der Ambiguität gelten, nicht nur im Sinne von genereller dichterischer Mehrdeutigkeit, sondern auch im etymologischen Sinne des Wortes (ambiguitas als ‚Doppelsinn‘). Der Beitrag untersucht, wie Ambiguität im Gedicht zum Ausdruck kommt und welche Funktionen sie übernimmt. Dabei fokussiert er auf bestimmte Aspekte wie die symmetrische Konstruktion des Titels und der Zeile „Anna Blume hat ein Vogel“ sowie auf die konkrete und abstrakte ,Ambi-Valenz‘ des Namen-Palindroms ,Anna‘. Durch das Spiel mit der konstitutiven Gespaltenheit der ambiguitas in Form und Semantik lässt Schwitters eine frappante Metapher entstehen, die in der Liebesdichtung des 20. Jahrhunderts unvergesslich bleibt
Adaptive Jamming Mitigation for Clustered Energy-Efficient LoRa-BLE Hybrid Wireless Sensor Networks
Get PDFWireless sensor networks (WSNs) are fundamental for modern IoT applications, yet they remain highly vulnerable to jamming attacks, which significantly degrade communication reliability and energy efficiency. This paper proposes a novel adaptive cluster-based jamming mitigation algorithm designed for heterogeneous WSNs that integrate LoRa and Bluetooth Low Energy (BLE) technologies. The proposed strategy dynamically switches between communication protocols, optimizes energy consumption, and reduces retransmissions under interference conditions by leveraging real-time network topology adjustments and adaptive transmission power control. Through extensive experimental validation, we demonstrate that our mitigation mechanism reduces energy consumption by up to 38% and lowers packet retransmission rates by 47% compared to single-protocol networks under jamming conditions. Additionally, our results indicate that the hybrid LoRa-BLE approach outperforms standalone LoRa and BLE configurations in terms of network resilience, adaptability, and sustained data transmission under attack scenarios. This work advances the state-of-the-art by introducing a multi-protocol interference-resilient communication strategy, paving the way for more robust, energy-efficient, and secure WSN deployments in smart cities, industrial IoT, and critical infrastructure monitoring
New [1]benzothieno[3,2-b]benzothiophene-tetraoxide-based TADF emitters with a D–A–D structure for OLED applications
Get PDFLuminescent organic molecules showing thermally activated delayed fluorescence (TADF) are appealing materials for high-efficiency OLEDs. Here, we report a new class of organic luminescent materials with TADF properties, and a D–A–D electronic structure based on [1]benzothieno[3,2-b]benzothiophene-tetraoxide BTBTOx4 as the acceptor unit A. Three donor units D were selected and coupled with BTBTOx4, using a straightforward synthetic protocol based on microwave-assisted Buchwald–Hartwig cross-coupling, to yield three organic luminescent molecules labelled PTz2-BTBTOx4, MPA2-BTBTOx4 and POCz2-BTBTOx4. Chemico-physical and structural properties were investigated by cyclic voltammetry, electrical measurements, crystallographic analysis, theoretical study and photophysical characterization. All three emitters showed high electrochemical stability with reversible oxidation waves. MPA2-BTBTOx4 was selected as the reference molecule for X-ray analysis, which revealed torsion angles of −59° and 86° between the donor (MPA) and acceptor (BTBTOx4) units supporting their appropriate structural configuration to have TADF properties. Photophysical studies highlighted a noteworthy increase in PL efficiency upon deoxygenation for all three compounds. The oxygen-induced quenching of delayed fluorescence and time-resolved photoluminescence studies supported the presence of the TADF properties, further corroborated for PTz2-BTBTOx4 and MPA2-BTBTOx4 by DFT studies. Preliminary steady-state photophysical studies were also carried out on neat films of all three emitters, revealing a pronounced self-quenching of photoluminescence for PTz2-BTBTOx4 and MPA2-BTBTOx4 and a minimal self-quenching for POCz2-BTBTOx4, which maintains a high ΦPL (22%) comparable to that in Zeonex and half of that in PMMA. As a proof of concept, the three emitting molecules were tested as neat films in simple-structure OLED devices. In accordance with the photoluminescence data, POCz2-BTBTOx4, thanks to its sterically bulky structure, retains a good emission capacity even in a neat film and was also selected as an active matrix to build OLED devices by using two different deposition techniques: inkjet-printing and spin coating
Collaborative Crisis Management: A Coordination Science Framework to Enhance Stakeholder Responses to Emergencies
No full textCrises caused by a broad spectrum of emergency triggers are creating unprecedented challenges for local and global institutions and business entities. The capacity of a system to respond and recover from a crisis is strongly influenced by the ability to manage coordination among "coalitions"of involved agents and to support dialogue and collaborative leadership. However, coordination science and engineering approaches have not been extensively investigated in crisis management studies and practitioner applications. This article is positioned in such a research gap and it adopts a cross-disciplinary view to design a novel crisis management paradigm, which defines coordination as a keystone of effective and efficient responses. In this article, we present a coordination core, with three key dependencies (i.e., fit, flow, and share) concerned with resource and activity management during a crisis, and four pillars of crisis prevention, crisis awareness, crisis response, and crisis recovery, with 64 associated attributes, including constructs, processes, tools, and analytics. We present two illustrative scenarios and we discuss that findings are made along a societal and organizational crisis management viewpoint. The article further develops crisis management theory by bringing a coordination engineering perspective, and it offers business leaders and policymakers a practical model for embedding crisis management capabilities in their organizations
Adsorption Isotherm Analysis for Hybrid Molecularly Imprinted Polymeric Gold-Decorated Nanoparticles Suitable for Reliable Quantification of Gluconic Acid in Wine
Get PDFA class of hybrid molecularly imprinted polymeric nanoparticles (nanoMIPs) comprising the in situ formation of gold nanoparticles (AuNPs) immobilised in a molecularly imprinted D-gluconate polymer has been designed with the objective of attempting the electro-chemical quantification of gluconic acid (GA) in a wine setting. The imprinted polymers were synthesised in the presence of AuNP precursors in a pre-polymerisation mixture, which were confined to one another during the polymerisation of the chains. This allowed the formation of hybrid electroactive responsive imprinted nanoparticles (hybrid AuNPs@GA-nanoMIP), which exhibited enhanced electron conductivity. The morphological characterisation of the produced nanoMIPs revealed a fully decorated Au spherical surface of 200 nm in diameter. This resulted in a large active surface area distribution, as well a pronounced electrochemical peak response at the commercial screen-printed platinum electrode (SPPtE), accompanied by enhanced electron kinetics. The AuNPs@GA-nanoMIP sensor demonstrated the ability to detect a broad range of GA concentrations (0.025–5 mg/mL) with exceptional selectivity and reproducibility. The calibration curves were fitted with different isotherm models, such as the Langmuir, Freundlich and Langmuir–Freundlich functions. Moreover, the efficacy of the detection method was demonstrated by the recovery rates observed in real samples of Italian red wine. This research contributes to the development of a robust and reliable electrochemical sensor for the on-site determination of gluconic acid in food analysis
The Role of Mitochondrial Solute Carriers SLC25 in Cancer Metabolic Reprogramming: Current Insights and Future Perspectives
Get PDFCancer cells undergo remarkable metabolic changes to meet their high energetic and iosynthetic demands. TheWarburg effect is the most well-characterized metabolic alteration, driving cancer cells to catabolize glucose through aerobic glycolysis to promote proliferation. Another prominent metabolic hallmark of cancer cells is their increased reliance on glutamine to replenish tricarboxylic acid (TCA) cycle intermediates essential for ATP production, aspartate and fatty acid synthesis, and maintaining redox homeostasis. In this context, mitochondria, which are primarily used to maintain energy homeostasis and support balanced biosynthesis in normal cells, become central organelles for fulfilling the heightened biosynthetic and energetic demands of proliferating cancer cells. Mitochondrial coordination and metabolite exchange with other cellular compartments are crucial. The human SLC25 mitochondrial carrier family, comprising 53 members, plays a pivotal role in transporting TCA intermediates, amino acids, vitamins, nucleotides, and cofactors across the inner mitochondrial membrane, thereby facilitating this cross-talk. Numerous studies have demonstrated that mitochondrial carriers are altered in cancer cells, actively contributing to tumorigenesis. This review comprehensively discusses the role
of SLC25 carriers in cancer pathogenesis and metabolic reprogramming based on current experimental evidence. It also highlights the research gaps that need to be addressed in future studies. Understanding the involvement of these carriers in tumorigenesis may provide valuable novel targets for drug development
